Antifungal Susceptibility Pattern in Otomycosis among Patients Attending a Tertiary Healthcare Institution in Port Harcourt, Nigeria

Oparaodu, U.; Lilly-Tariah, O B da; Warriso, Kennedy

doi:10.9734/ajmah/2022/v20i230432

Cited by 2 publications

(2 citation statements)

References 8 publications

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“…ketoconazole and fluconazole and amphotericin b had the poorest activity. This study is comparable with Sathiet al (2022) in Bangladesh showed 95% sensitive to voriconazole and 67% resistant to fluconazole and Oparaodu et al (2022) in Nigeria showed that highest sensitivity to voriconazole (76.9%) and highest resistance was to fluconazole (84.6%) and nystatin (53.9%) for yeast and highest sensitivity to voriconazole (66.7%) and 100% resistance to fluconazole for mold. 13,14 This study differ in resistant pattern with for mold showed nystatin (100%) resistant.…”

Section: Resultssupporting

confidence: 89%

“…This study is comparable with Sathiet al (2022) in Bangladesh showed 95% sensitive to voriconazole and 67% resistant to fluconazole and Oparaodu et al (2022) in Nigeria showed that highest sensitivity to voriconazole (76.9%) and highest resistance was to fluconazole (84.6%) and nystatin (53.9%) for yeast and highest sensitivity to voriconazole (66.7%) and 100% resistance to fluconazole for mold. 13,14 This study differ in resistant pattern with for mold showed nystatin (100%) resistant. ketoconazole, fluconazole, amphotericin b showed highest resistance due to its low cost and its widespread availability in all levels of health care centers which in turns turned into increase drug resistance.…”

Section: Resultssupporting

confidence: 89%

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Fungal Agents Causing Chronic Otitis Externa with Their Antimicrobial Susceptibility Pattern at RMCH

Mahjabin,

Alam,

Nahar

et al. 2023

TAJ: J of Teachers Assoc

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Background: Otomycosis is a well prevalent disease (9-30%) in our country which even might persist for more than 3 months (chronic cases). Now a days, development of antimicrobial drug resistant making difficult to treat such patients all over the world. Objective: To identify fungal agents causing chronic otitis externa with their antimicrobial susceptibility in Rajshahi Medical College Hospital. Material and Method: This cross-sectional descriptive study was conducted from January 2022 to December 2022 in the department of Microbiology at Rajshahi Medical College, Rajshahi. About 110 suspected chronic otitis externa patients were selected from outpatient department of ENT of RMCH & data were collected by a semi structured questionnaire. Fungal organisms isolated and identified by culture, LPCB stain and relevant tests including a specific Czapek Dox Agar media. Antimicrobial susceptibility was done by modified Kirby Bauer disc diffusion method. Data were analyzed using SPSS (version 24.0). Statistical significance was considered when p value < 0.05. Result: In this study, near half (48.18%) aural swab from respondent of chronic otomycosis were culture positive for different fungal species. Among all, A. niger was most common species (50.9%) & 1/5th of them was C. albicans (20.8%) along with other species. Most sensitive drug for different fungal species were voriconazole &itraconazole and most resistant drug were fluconazole and ketoconazole. Conclusion: As common antifungal drugs are resistant to different fungal species & their susceptibility pattern are changes day by day, among otomycosis patients the fungal culture & antimicrobial susceptibility should be done to reduce the morbidity of such patients as well as to reduce the generation of new resistance to antifungal drugs. TAJ 2023; 36: No-2: 185-192

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Section: Resultssupporting

confidence: 89%

Section: Resultssupporting

confidence: 89%

Fungal Agents Causing Chronic Otitis Externa with Their Antimicrobial Susceptibility Pattern at RMCH

Mahjabin,

Alam,

Nahar

et al. 2023

TAJ: J of Teachers Assoc

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Antifungal Susceptibility Pattern of Fungi Isolated from Patients with Otomycosis Attending a Tertiary Health Care Institution in Sokoto, Nigeria

Yabo,

Robert,

Mohammed

2024

Saudi Journal of Otorhinolaryngology Head and Neck Surgery

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Background: Antifungal therapy is an important component of patient management for acute and chronic mycoses. However, treatment choices are restricted because of the scanty number of antifungal drug classes. Medical treatment of otomycosis is further compromised by the emergence of antifungal drug resistance, and these limits available drug classes as treatment options. Once considered a rare occurrence, antifungal drug resistance is on the rise in many high-risk medical centers. Most concerning is the evolution of multidrug-resistant organisms refractory to several different classes of antifungal agents, especially among common Candida species. Aim: This study seeks to identify the fungal species implicated in otomycosis among patients attending a tertiary health-care institution in Sokoto, Nigeria and determine its susceptibility pattern using commonly used antifungal agents. Methods: A descriptive, cross-sectional, hospital-based study was conducted on 100 patients with otitis externa. The ear discharge specimens were collected and analyzed using the standard microbial techniques. The antibiotic susceptibility profiles were determined for 12 different antifungal by the standard disk diffusion method. Data were analyzed using the SPSS software version 25 and the P < 0.05 was considered as statistically significant. Results: One hundred and twenty-four external ear discharge samples were collected from either right ear, left ear, or both ears (some patients has unilateral while others have bilateral disease and those with bilateral disease, samples were taken from the two ears). Aspergillus niger 30 (40.0%) was the most commonly isolated fungi in this study, followed by Candida spp. 25 (33.3%), Aspergillus fumigatus 5 (6.7%), Mucor 5 (6.7%), Penicillum 4 (5.3%), Aspergillus flavus 3 (4.0%), and Rhizopus 3 (4.0%) %). The isolated fungi were tested for antifungal sensitivity to 6 antifungal discs. A. niger shows good susceptibility to clotrimazole (100%), nystatin (90%), and fluconazole (83.3%) but was resistant to griseofulvin, terbinafine, and ketoconazole. A. flavus and A. fumigatus also show good sensitivity to clotrimazole, nystatin, and fluconazole. Candida albicans was only susceptible to clotrimazole but resistant to other tested antifungal disc. Rhizopus and Penicillum species showed 100.0% sensitivity to clotrimazole but also resistant to other tested antifungal discs. Conclusions: This study revealed that Aspergillus and Candida species were the most common fungal pathogens causing otomycosis. A. niger is the predominant fungal isolate. Molds isolates showed good susceptibility to clotrimazole, while highest resistance was to terbinafine and ketoconazole. Yeasts isolates showed highest susceptibility to clotrimazole and highest resistance to nystatin and fluconazole.

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Antifungal Susceptibility Pattern in Otomycosis among Patients Attending a Tertiary Healthcare Institution in Port Harcourt, Nigeria

Cited by 2 publications

References 8 publications

Fungal Agents Causing Chronic Otitis Externa with Their Antimicrobial Susceptibility Pattern at RMCH

Fungal Agents Causing Chronic Otitis Externa with Their Antimicrobial Susceptibility Pattern at RMCH

Antifungal Susceptibility Pattern of Fungi Isolated from Patients with Otomycosis Attending a Tertiary Health Care Institution in Sokoto, Nigeria

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