Antifungal versus antibacterial defence of insect wings

Ivanova, Elena P.; Linklater, Denver P.; Aburto‐Medina, Arturo; Le, Phuc H.; Baulin, Vladimir A.; Nguyen, Duy H. K.; Curtain, Roger; Hanssen, Eric; Gervinskas, Gediminas; Ng, Soon Hock; Truong, Vi Khanh; Luque, Pere; Ramm, Georg; Wösten, Han A. B.; Crawford, Russell J.; Juodkazis, Saulius; MacLaughlin, Shane A.

doi:10.1016/j.jcis.2021.06.093

Cited by 33 publications

(41 citation statements)

References 43 publications

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“…By inhibiting fungal biofilm, the function of the HTE‐Ti surface can be compared to the recent observations made by Ivanova and colleagues, [ 57 ] who showed that the nanostructured wings of the Damselfly repel fungal cells. Although the biofilm inhibiting effect is similar between the Damselfly wing and HTE‐Ti, their mechanisms are quite different.…”

Section: Discussionmentioning

confidence: 99%

“…The Damselfly wing is a hydrophobic surface which entraps a layer of air between nanopillars, and this air layer reduces the propensity for fungal cells to attach to the surface. [ 57 ] The HTE‐Ti surface is highly hydrophilic and thus there can be no trapped air to exert this effect. The biofilm inhibition observed on HTE‐Ti is therefore more attributable to the mechanical interactions between the fungus and the nanostructures.…”

Section: Discussionmentioning

confidence: 99%

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Spiked Nanostructures Disrupt Fungal Biofilm and Impart Increased Sensitivity to Antifungal Treatment

Hayles

Bright

Wood

et al. 2022

Adv Materials Inter

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The superiority of titanium as a biomaterial is reflected in its corrosion resistance, mechanical strength, biocompatibility, and osseointegration capabilities. [1a] Although there is a high success rate associated with implanted devices, failure is not uncommon. One of the primary causes of implant failure is implantassociated infections (IAI). [2] In the field of orthopaedics, approximately 1-2% of joint replacement arthroplasties result in IAI. [3] The IAI rate is significantly higher in the periodontal field, with peri-implantitis seen in as many as 1 in 3 patients. [4] Infections involving fungal pathogens are emerging in both of these clinical fields, and Candida species are detected in as many as 90% of fungal IAI cases. [5] Candida albicans represents the most common fungal threat, but other notable species include Candida parapsilosis, Candida tropicalis, and Candida glabrata. [5d] In polymicrobial biofilms, C. albicans can protect Porphyromonas gingivalis from adverse conditions [6] and promote drug resistance in Staphylococcus aureus. [7] Its common occurrence in IAI can be attributed to the fact that C. albicans is found amongst the normal skin microbiota as a commensal microbe, and can occasionally translocate from the skin to the implanted device during surgery. [8] In a subset of the population, such as diabetics or those who have an otherwise compromised immune system, C. albicans can switch from its normal commensal state to an opportunistic pathogen. This is of particular concern because once a fungal infection becomes systemic, it is associated with a mortality rate of up to 50%. [9] In systemic candidiasis, the kidney is one of the primary organs to be affected, commonly leading to renal failure. [10] As a fungal pathogen, the virulence mechanisms of C. albicans differ from bacterial pathogens. One striking difference is the ability of pathogenic fungi to reversibly switch between two alternate phenotypes-an ovoid-shaped yeast phenotype and a filamentous hyphal phenotype, and this process is referred to as morphogenesis. [11] The yeast phenotype is associated with initial surface colonization, and later dissemination. The hyphal phenotype acts as structural support and promotes tissue invasion. [12] Invasion of host tissue allows C. albicans to enter the bloodstream and translocate around the body. Within the bloodstream, the presence of serum and the slightly alkaline pH provides ideal conditions for hyphal cell growth, which then allows the pathogen to invade There is a globally increasing demand for medically implanted devices, partly spurred by an aging population. In parallel, there is a proportionate increase in implant associated infection. Much focus has been directed toward the development of techniques to fabricate nanostructured antimicrobial biomaterials to mitigate infection. The present study investigates the interaction of the fungal pathogen Candida albicans with an antimicrobial surface bearing nanoscale protrusions. C. albicans cells were observed to be affected by cell ...

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Spiked Nanostructures Disrupt Fungal Biofilm and Impart Increased Sensitivity to Antifungal Treatment

Hayles

Bright

Wood

et al. 2022

Adv Materials Inter

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“…Many studies have investigated how micro/nano-scale topographies affect bacterial adhesion. Discrete, ordered, and hierarchical surface structures from nano-scale to micro-scale were self-assembled, designed, or bioinspired by mimicking natural surfaces (such as skins of marine mammals and sharks, shells of mollusks and crabs, wings of insects and birds, and leaves of plants) [131,132].…”

Section: Topographic Modification Strategymentioning

confidence: 99%

Antifouling Strategies-Interference with Bacterial Adhesion

Jia¹

2022

Focus on Bacterial Biofilms

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Biofilm refers to a viable bacterial community wrapped in self-produced extracellular polymeric substances (EPS) matrix. As bacteria shielded by EPS are viable and can resist broad hostile environments and antimicrobial agents, biofilm poses a massive challenge to industries and human health. Currently, biofilm has accounted for widespread and severe safety issues, infections, and economic loss. Various antifouling strategies have been designed and developed to prevent biofilm formation. As bacterial biofilm is perceived as a dynamic multistage process in which bacterial attachment on solid surfaces is the prerequisite for biofilm formation, the interference with the attachment is the most promising environmentally benign option to antifouling. The chapter summarizes and discusses the antifouling strategies that interfere with the adhesion between bacteria and substrate surfaces. These strategies primarily focus on modifying the substrate surface’s topographical and physicochemical properties.

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“…Unlike the cicada, the protrusions are irregular and conical [58], and reported to be varying among different species with a range of 70 to 195 nm [19,103,104]. The dragonfly wing structures are active against both gram-positive and gram-negative bacteria [105] and exhibit both antibacterial and antifouling properties [106]. Hydrothermal synthesis [107] and reactive ion etching [93] are fabrication techniques that can produce effective antibacterial surfaces with the dragonfly pattern.…”

Section: Insect-inspired Patternsmentioning

confidence: 99%

Carbon Nanomaterials Modified Biomimetic Dental Implants for Diabetic Patients

et al. 2021

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Dental implants are used broadly in dental clinics as the most natural-looking restoration option for replacing missing or highly diseased teeth. However, dental implant failure is a crucial issue for diabetic patients in need of dentition restoration, particularly when a lack of osseointegration and immunoregulatory incompetency occur during the healing phase, resulting in infection and fibrous encapsulation. Bio-inspired or biomimetic materials, which can mimic the characteristics of natural elements, are being investigated for use in the implant industry. This review discusses different biomimetic dental implants in terms of structural changes that enable antibacterial properties, drug delivery, immunomodulation, and osseointegration. We subsequently summarize the modification of dental implants for diabetes patients utilizing carbon nanomaterials, which have been recently found to improve the characteristics of biomimetic dental implants, including through antibacterial and anti-inflammatory capabilities, and by offering drug delivery properties that are essential for the success of dental implants.

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Antifungal versus antibacterial defence of insect wings

Cited by 33 publications

References 43 publications

Spiked Nanostructures Disrupt Fungal Biofilm and Impart Increased Sensitivity to Antifungal Treatment

Spiked Nanostructures Disrupt Fungal Biofilm and Impart Increased Sensitivity to Antifungal Treatment

Antifouling Strategies-Interference with Bacterial Adhesion

Carbon Nanomaterials Modified Biomimetic Dental Implants for Diabetic Patients

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