Antigen-induced neutrophil chemotactic activity in man *1Correlation with bronchospasm and inhibition by disodium cromoglycate

Atkins, Paul C.; Norman, Michael E.; Zweiman, Burton

doi:10.1016/0091-6749(78)90099-4

Cited by 126 publications

(21 citation statements)

References 15 publications

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“…Mast cell degranulation may release chemotactic factors that mobilize or densitize circulating neutrophils (Atkins et al, 1978;Soter, 1980;Tannenbaum et al, 1980) while access of the neutrophils to the site of inflammation (Atherton & Born, 1972) may be enhanced as a result of increased vascular permeability caused by histamine and 5-HT. Such a role for the biogenic amines would be consistent with the partial antagonism observed with mepyramine and methysergide.…”

Section: Discussionmentioning

confidence: 99%

Anti‐inflammatory activity of bee venom peptide 401 (mast cell degranulating peptide) and compound 48/80 results from mast cell degranulation in vivo

Banks

Dempsey

Vernon

et al. 1990

British J Pharmacology

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Section: Discussionmentioning

confidence: 99%

Anti‐inflammatory activity of bee venom peptide 401 (mast cell degranulating peptide) and compound 48/80 results from mast cell degranulation in vivo

Banks

Dempsey

Vernon

et al. 1990

British J Pharmacology

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“…High-molecular-weight neutro phil chemotactic activity was detected in human serum after antigen challenge and may originate from mast cell degranulation [1,2]. In exercise-induced asthma, the appearance of neutrophil chemotactic ac tivity (NCA) in the serum closely accompanied the immediate falls in forced expiratory volume of 1.0 s [3,4], These reports show that circulating NCA may play a role in the development of airflow obstruction.…”

Section: Introductionmentioning

confidence: 95%

Density Distribution and Density Conversion of Neutrophils in Allergic Subjects

Miyagawa

Okada

Sugiyama

et al. 1990

Int Arch Allergy Immunol

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We investigated the density distribution of neutrophils in peripheral blood of allergic subjects. We divided neutrophils into four groups: fraction 1 (density > 1.085), fraction 2 (1.081 < density ≤ 1.085), fraction 3 (1.077 < density ≤ 1.081) and fraction 4 (density ≤ 1.077). The percentage of neutrophils in fraction 2 in allergic rhinitis (AR) subjects or asthmatics was lower than that in normals (p < 0.01). The percentage of neutrophils in fraction 3 and fraction 4 from AR or asthmatics was greater than that in normals (fraction 3, p < 0.01; fraction 4, p < 0.05). In neutrophils from AR subjects (fraction 3), chemotaxis to N-formyl-methionyl-leucyl-phenylalanine or platelet-activating factor (PAF) was enhanced compared to fraction 2. PAF (10^––7M) changed the density of neutrophils (p < 0.01), which were inhibited by WEB 2086 (p < 0.05). Furthermore, granulocyte-macrophage colony-stimulating factor changed the density of neutrophils (p < 0.01). These findings suggest that biological agents may activate neutrophils and convert their density resulting in neutrophils with lower density in allergic subjects.

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“…NCF release after challenge in cold urticaria closely paralleled the appearance of recognized mast cell mediators such as histamine and the eosinophil chemotactic factor of anaphylaxis (ECF-A) (2). Bronchial challenge in asthmatics with nonspecific agents such as methacholine was not associated with the release of NCF, whereas prior administration of disodium cromoglycate to asthmatics challenged with specific antigen inhibited both the increase in airways obstruction and the appearance of NCF into the circulation (5,6).…”

Section: Introductionmentioning

confidence: 99%

Identification and partial characterization of an exercise-induced neutrophil chemotactic factor in bronchial asthma.

Lee¹,

Nagy²,

Nagakura³

et al. 1982

J. Clin. Invest.

186

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A B S T R A C T A heat-stable neutrophil chemotactic factor (NCF) has been identified in the serum of 13 atopic asthmatic subjects after treadmill exercise. Peak activity was detected at 10 min and returned to prechallenge values by 1 h. No NCF activity was detected in the sera of three nonasthmatic atopic or four normal nonatopic individuals performing the same task. NCF produced by exercise (NCFEX) had a similar timecourse of release to NCF provoked by specific antigen (NCFAG). The appearance of circulating NCFEX and NCFAG closely paralleled the fall in peak expiratory flow rate/forced expiratory volume in 1 s (PEFR/ FEVI). Histamine challenge in atopic asthmatics at concentrations giving a comparable change in PEFR/ FEVy to that evoked by exercise or inhaled antigen was not associated with the appearance of circulating NCF. In seven subjects NCFEX release was inhibited by prior administration of disodium cromoglycate. NCFEX and NCFAG eluted as single peaks of activity when applied separately to columns of Sephadex G-200, and both were an estimated 750,000 daltons. NCFEX and NCFAG also eluted as single peaks of activity, at between 0.15 and 0.30 M NaCl, following anion exchange chromatography on DEAE-Sephacel (pH 7.8). The isoelectric points of NCFEX and NCFAG were virtually identical (between pH 6.0 and 6.5) as determined by chromatofocusing on Polybuffer Exchanger 94. The activities of NCFEx and NCFAG were substantially reduced, in both a time-and dose-dependent fashion, after incubation with trypsin and chymotrypsin. Partially purified NCFEX and NCFAG promoted both stimulated random migration (chemokinesis) as well as directional migration (chemotaxis).These experiments indicate that NCFEX and NCFAG might be identical substances and raise the possibility

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Antigen-induced neutrophil chemotactic activity in man *1Correlation with bronchospasm and inhibition by disodium cromoglycate

Cited by 126 publications

References 15 publications

Anti‐inflammatory activity of bee venom peptide 401 (mast cell degranulating peptide) and compound 48/80 results from mast cell degranulation in vivo

Anti‐inflammatory activity of bee venom peptide 401 (mast cell degranulating peptide) and compound 48/80 results from mast cell degranulation in vivo

Density Distribution and Density Conversion of Neutrophils in Allergic Subjects

Identification and partial characterization of an exercise-induced neutrophil chemotactic factor in bronchial asthma.

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