Antigen stabilizing hydrogels based on cyclodextrins and polyethylene glycol act as type-2 adjuvants with suppressed local irritation

Hayashi, Tomoya; Nakagawa, Fumika; Ohno, Yoshitaka; Suzuki, Yuzo; Ishiki, Honatsu; Onodera, Risako; Higashi, Taishi; Shimamura, Yoshihisa; Itou, Hiroshi; Iwase, Yoichiro; Arima, Hisatomi; Motoyama, Keiichi

doi:10.1016/j.ejpb.2022.11.002

Cited by 2 publications

(1 citation statement)

References 54 publications

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“…However, with the excessive increase of β-CD content, agglomeration and other phenomena will occur in the β-CD/WPU composite system, [19][20][21][22][23] it can be effectively circumvented by using PEG to modify β-CD before introducing it into WPU. PEG molecular chains have hydrophobic chain segments and hydrophilic ether bonds and hydroxyl groups.…”

Section: Introductionmentioning

confidence: 99%

Dual network interpenetrating degradable waterborne polyurethanes with hydrogen bonded cross‐linked modified β‐cyclodextrin hydrophobic cavities

Fan

Song

Liu

et al. 2023

J of Applied Polymer Sci

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The study gives an investigation on the properties of β‐cyclodextrin (β‐CD) waterborne polyurethane (WPU) composites with cross‐linked network structure and hydrogen bonding system. The polyurethane films modified with β‐CD/PEG exhibit superior thermal stability and biodegradability, it is capable to be applied to bio‐degradable plastic coatings. To improve the distribution of β‐CD in WPU, the β‐CD was modified by three different molecular weights of polyethylene glycol hydrophile (PEG). Since the chain segments and hydrophilic hydroxyl groups of PEG interact with the hydrophobic cavities and edges of β‐CD to form new complexes, thus enhancing the flexibility and structural integrity of WPU chains and conferring better biological properties. The analysis focuses on the changes of thermal stability and biodegradability after modification. The results indicated that the temperature of maximum thermal weight loss rate (Tmax) of β‐CD/PEG/WPU composites reached 394.1°C and the soft segment glass transition temperature (Tg) was −42.4°C after the introduction of β‐CD/PEG. Both are significantly improved compared to WPU, with degradation rates of 31.2% in lipase PBS solution and 14.8% in soil, and can therefore be better applied to current medical devices and biodegradable coatings, as well as other bio‐environmental areas.

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Section: Introductionmentioning

confidence: 99%

Dual network interpenetrating degradable waterborne polyurethanes with hydrogen bonded cross‐linked modified β‐cyclodextrin hydrophobic cavities

Fan

Song

Liu

et al. 2023

J of Applied Polymer Sci

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Development of Cyclodextrin-Based Materials and Their Application to Pharmaceuticals

Higashi

MOTOYAMA

2023

Oleoscience

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Natural cyclodextrins (CDs) and their derivatives are host molecules that form inclusion complexes with hydrophobic drugs and are widely applied as pharmaceutical additives and DDS carriers in the pharmaceutical field. Recently, supramolecular necklaces using CDs have also been attracting attention, and their functions have been found to be superior to those of conventional low-molecular-weight or high-molecular-weight drug formulation materials. In addition, a paradigm shift is taking place in which CDs themselves are being used as active pharmaceutical ingredients. This paper reviews the creation of CD-based materials and their application to pharmaceuticals.

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Antigen stabilizing hydrogels based on cyclodextrins and polyethylene glycol act as type-2 adjuvants with suppressed local irritation

Cited by 2 publications

References 54 publications

Dual network interpenetrating degradable waterborne polyurethanes with hydrogen bonded cross‐linked modified β‐cyclodextrin hydrophobic cavities

Dual network interpenetrating degradable waterborne polyurethanes with hydrogen bonded cross‐linked modified β‐cyclodextrin hydrophobic cavities

Development of Cyclodextrin-Based Materials and Their Application to Pharmaceuticals

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