Antigen stimulation of TH2 cells augments acute bacterial sinusitis in mice

Yu, Xiaohong; Sperling, Anne I.; Blair, Christopher; Thompson, Kenneth D.; Naclerio, Robert M.

doi:10.1016/j.jaci.2004.04.051

Cited by 16 publications

(12 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…118,119 Mice with ongoing nasal allergic reaction (but not mice with lower airway reaction or sensitization alone) had a worsened episode of ARS, and this effect could be transferred by Th cells. These studies suggest that local allergic inflammation plays an important role in the expression of ARS.…”

Section: Vb Ars: Pathophysiologymentioning

confidence: 99%

International Consensus Statement on Allergy and Rhinology: Rhinosinusitis

Orlandi

Kingdom

Hwang

et al. 2016

Int Forum Allergy Rhinol

Self Cite

558

888

View full text Add to dashboard Cite

Background:The body of knowledge regarding rhinosinusitis (RS) continues to expand, with rapid growth in number of publications, yet substantial variability in the quality of those presentations. In an effort to both consolidate and critically appraise this information, rhinologic experts from around the world have produced the International Consensus Statement on Allergy and Rhinology: Rhinosinusitis (ICAR:RS). Methods:Evidence-based reviews with recommendations (EBRRs) were developed for scores of topics, using previously reported methodology. Where existing evidence was insufficient for an EBRR, an evidence-based review (EBR) was produced. The sections were then synthesized and the entire manuscript was then reviewed by all authors for consensus. Results:The resulting ICAR:RS document addresses multiple topics in RS, including acute RS (ARS), chronic RS (CRS) with and without nasal polyps (CRSwNP and CRSsNP), recurrent acute RS (RARS), acute exacerbation of CRS (AE-CRS), and pediatric RS. Conclusion:As a critical review of the RS literature, ICAR:RS provides a thorough review of pathophysiology and evidence-based recommendations for medical and surgical treatment. It also demonstrates the significant gaps in our understanding of the pathophysiology and optimal management of RS. Too o en the foundation upon which these recommendations are based is comprised of lowerlevel evidence. It is our hope that this summary of the evidence in RS will point out where additional research efforts may be directed. C 2016 ARS-AAOA, LLC. Key Words:rhinosinusitis; chronic rhinosinusitis; acute rhinosinusitis; recurrent acute rhinosinusitis; evidence-based medicine; systematic review; endoscopic sinus surgery List of Abbreviations Used

show abstract

Section: Vb Ars: Pathophysiologymentioning

confidence: 99%

International Consensus Statement on Allergy and Rhinology: Rhinosinusitis

Orlandi

Kingdom

Hwang

et al. 2016

Int Forum Allergy Rhinol

Self Cite

558

888

View full text Add to dashboard Cite

show abstract

“…This could result from a genetic or environmentally-induced predisposition to producing Th2 responses in general, or be mediated via bystander interactions with the responses to allergens. The latter possibility has been demonstrated by experiments with viral and bacterial infections of sensitised mice 7 – 9. A greater involvement of the Th2 component of the response of children with aeroallergies to childhood vaccines has been observed 10 – 12.…”

mentioning

confidence: 94%

Differences in the antibody response to a mucosal bacterial antigen between allergic and non-allergic subjectsSmoke-free legislation reduces exposure in children

Hales

Pearce

Kusel

et al. 2008

Thorax

View full text Add to dashboard Cite

Background: The immune response to bacterial antigens on mucosal surfaces may be modified in individuals allergic to aeroallergens due to a maturational or genetic difference or from the interaction between inhaled allergens and bacteria at the mucosa. Methods: Plasma from children and adults allergic (n = 97) and non-allergic (n = 54) to aeroallergens were initially tested for IgG1 (Th1) and IgG4 (Th2) reactivity to P6, a conserved outer membrane protein of Haemophilus influenzae. IgE binding was measured for some allergic donors. The development of the antibody responses to P6 was subsequently examined in the plasma from 35 children aged 1, 2 and 5 years taken from a prospective birth cohort. Results: IgG4 antibodies to P6 were more readily detected in allergic subjects than in non-allergic subjects (p,0.001), with a strong bias to the male gender. Some allergic subjects (35%) also had IgE antibody (1-10 ng/ ml) that was not associated with IgG4 or gender. In the cohort study of infants, subjects who developed skin prick test positivity to mite allergens by 5 years of age had an 85% reduction in the IgG1 anti-P6 antibody at year 2 (p,0.05) and, unlike skin test negative infants, this group had IgG4 anti-P6 antibodies at 5 years of age. Conclusions: The antibodies of subjects allergic to a bacterial antigen included IgE and IgG4 (particularly for males) compared with the almost exclusive IgG1 response of non-allergic subjects. The IgG1 responses of 2-year-old children who became skin test positive was markedly reduced and P6-specific IgG4 became detectable at 5 years of age.The T cell responses of children who develop allergic sensitisation have been shown to mature slowly. The late maturation has been demonstrated in T cell precursor analyses, 1 responses to mitogens 2 3 and in the production of Th1 and Th2 cytokines induced by allergens.4 5 Both Th1 and Th2 responses are lower in allergic infants, 4 but the Th1 cytokine production has been a centre of focus because interferon-c (IFNc) responses are very slow to mature in children, 6 leaving the possibility that Th2 imprinting in the neonatal period can persist into infancy. Most of the studies of cytokine regulation of allergic sensitisation have examined the response to allergens. An effect on responses to other antigens could also be expected. This could result from a genetic or environmentally-induced predisposition to producing Th2 responses in general, or be mediated via bystander interactions with the responses to allergens. The latter possibility has been demonstrated by experiments with viral and bacterial infections of sensitised mice.7-9 A greater involvement of the Th2 component of the response of children with aeroallergies to childhood vaccines has been observed. [10][11][12] The responses to mucosal antigens where co-presentation could occur with allergens would therefore be of interest.To study immune responses to an antigen presented at the respiratory mucosa, the IgE and IgG subclass antibodies induced by a conserved outer membrane p...

show abstract

“…T H 2 cells, besides playing a role in fighting extracellular pathogens, promote IgE production and eosinophil function, which are key players in the pathogenesis of allergic inflammation. 4 Allergeninduced up-regulation of T H 2 cytokines has been proved to play an important role in the pathogenesis of allergy. 5 A shift from T H 1 to T H 2 response can enhance both infectious and allergic diseases.…”

mentioning

confidence: 99%

Effect of Genetic Background on the Response to Bacterial Sinusitis in Mice

Kirtsreesakul

Luxameechanporn²,

Klemens³

et al. 2006

Arch Otolaryngol Head Neck Surg

Self Cite

View full text Add to dashboard Cite

To study the importance of ongoing allergen exposure and T H 1/T H 2 genetic background in augmented bacterial and inflammatory responses in allergic and infected mice.Design: BALB/c and C57BL/6 mice were made allergic to ovalbumin. After 1 day of intranasal allergen exposure, they were inoculated intranasally with Streptococcus pneumoniae. The numbers of bacteria and inflammatory cells in the sinuses were determined, and nasal responsiveness to histamine was assessed.Results: Infected BALB/c and C57BL/6 mice that received ongoing ovalbumin challenge following intraperitoneal sensitization showed significantly greater bacterial load and phagocyte level compared with the infected-only mice. Differences were diminished after the allergen challenge was stopped. Allergic and infected C57BL/6 mice showed fewer bacteria and phagocytes compared with the allergic and infected BALB/c mice. Surprisingly, in contrast to the nonallergenic C57BL/6 mice, the infected BALB/c mice showed a larger number of bacteria 28 days after infection.Conclusions: Ongoing allergic reaction augments bacterial load in both BALB/c and C57BL/6 mice and induces nasal hyperreactivity to histamine. Allergic and infected C57BL/6 mice show less allergic inflammation and bacterial load compared with allergic and infected BALB/c mice. Stopping allergen exposure reduces the response. Infected BALB/c mice, which favor a T H 2 response, were less able to clear infection than C57BL/6 mice, which favor a T H 1 response. Inflammation and bacterial load are affected by genetic background of mice and ongoing allergen stimulation.

show abstract

Antigen stimulation of TH2 cells augments acute bacterial sinusitis in mice

Cited by 16 publications

References 31 publications

International Consensus Statement on Allergy and Rhinology: Rhinosinusitis

International Consensus Statement on Allergy and Rhinology: Rhinosinusitis

Differences in the antibody response to a mucosal bacterial antigen between allergic and non-allergic subjectsSmoke-free legislation reduces exposure in children

Effect of Genetic Background on the Response to Bacterial Sinusitis in Mice

Contact Info

Product

Resources

About