Antigenic and molecular heterogeneity in recent swine influenza A(H1N1) virus isolates with possible implications for vaccination policy

Jong, J.C. de; Heinen, Paul P.; Loeffen, W.L.A.; Nieuwstadt, A. P. van; Claas, Eric C. J.; Bestebroer, Theo M.; Bijlsma, K; Verweij, C.A.; Osterhaus, Albert D. M. E.; Rimmelzwaan, Guus F.; Fouchier, Ron A. M.; Kimman, Tjeerd G.

doi:10.1016/s0264-410x(01)00190-6

Cited by 35 publications

(24 citation statements)

References 19 publications

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“…It is commonly thought that SwIV undergoes less antigenic rstb.royalsocietypublishing.org Phil Trans R Soc B 368: 20120382 change than human influenza viruses [33,34], possibly because the short lifespan of farmed swine (approx. 150 days) lowers the chance of re-infection.…”

Section: Discussionmentioning

confidence: 99%

The evolutionary dynamics of influenza A virus adaptation to mammalian hosts

Bhatt

Lam

Lycett

et al. 2013

Phil. Trans. R. Soc. B

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Few questions on infectious disease are more important than understanding how and why avian influenza A viruses successfully emerge in mammalian populations, yet little is known about the rate and nature of the virus’ genetic adaptation in new hosts. Here, we measure, for the first time, the genomic rate of adaptive evolution of swine influenza viruses (SwIV) that originated in birds. By using a curated dataset of more than 24 000 human and swine influenza gene sequences, including 41 newly characterized genomes, we reconstructed the adaptive dynamics of three major SwIV lineages (Eurasian, EA; classical swine, CS; triple reassortant, TR). We found that, following the transfer of the EA lineage from birds to swine in the late 1970s, EA virus genes have undergone substantially faster adaptive evolution than those of the CS lineage, which had circulated among swine for decades. Further, the adaptation rates of the EA lineage antigenic haemagglutinin and neuraminidase genes were unexpectedly high and similar to those observed in human influenza A. We show that the successful establishment of avian influenza viruses in swine is associated with raised adaptive evolution across the entire genome for many years after zoonosis, reflecting the contribution of multiple mutations to the coordinated optimization of viral fitness in a new environment. This dynamics is replicated independently in the polymerase genes of the TR lineage, which established in swine following separate transmission from non-swine hosts.

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Section: Discussionmentioning

confidence: 99%

The evolutionary dynamics of influenza A virus adaptation to mammalian hosts

Bhatt

Lam

Lycett

et al. 2013

Phil. Trans. R. Soc. B

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“…Similarly, there were only low to moderate degrees of cross-reactivity among recent H1N1 and H1N2 SIV isolates from the United States (53). These studies indicate that genetic and antigenic heterogeneities that might reduce vaccine effectiveness occur within each subtype of SIV (5,42). In addition, killed-virus vaccine formulations induce mainly humoral immune responses while complete protection from SIV infections might require both humoral and cell-mediated immunity (16).…”

mentioning

confidence: 83%

Vaccination of Pigs against Swine Influenza Viruses by Using an NS1-Truncated Modified Live-Virus Vaccine

Richt

Lekcharoensuk

Lager

et al. 2006

J Virol

163

129

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“…For this, five reference antigens of influenza were used: A/swine/Netherlands/Best/96 (European swine H1N1) (de Jong et al, 2001), A/swine/Gent/7625/99 (European swine H1N2) (Marozin et al, 2002), A/swine/Netherlands/St Oedenrode/96 (European swine H3N2) (de Jong et al, 1999), A/Port Chalmers/1/73 (H3N2 of human origin) (Schild et al, 1974) and A/Netherlands/602/2009 (pandemic H1N1) (Munster et al, 2009). …”

Section: Antibodies Against Swine Influenza Virus (Siv)mentioning

confidence: 99%