Antigenic Characterization of &lt;I&gt;Pasteurella pneumotropica&lt;/I&gt;Isolated from Mice and Rats

Nakagawa, Masaro; Saito, Manabu

doi:10.1538/expanim1978.33.2_187

Cited by 8 publications

(3 citation statements)

References 9 publications

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“…The organism has 2 biovars, Jawetz and Heyl, which are regarded as 2 distinct species based on the molecular data. Antigenic differences have been demonstrated between mouse and rat strains [18], but serotypes have not yet been established. Based on 16S rDNA sequence analysis, the Pasteurellaceae are divided into 21 phylogenetic clusters; P. pneumotropica belongs to the rodent cluster but not to Pasteurella sensu stricto [7].…”

Section: Introductionmentioning

confidence: 99%

Pathogenicity of Pasteurella pneumotropica in Immunodeficient NOD/ShiJic-scid/Jcl and Immunocompetent Crlj:CD1 (ICR) Mice

et al. 2011

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Abstract:Pasteurella pneumotropica is an opportunistic pathogen in rodents. Natural infection in immunodeficient animals suggests that immunodeficiency is a major factor in P. pneumotropica pathogenesis. To understand this process, we performed clinical, pathological and bacteriological studies of immunodeficient NOD/ShiJic-scid/Jcl and immunocompetent Crlj:CD1 (ICR) mice experimentally infected with P. pneumotropica ATCC 35149. From 14 days postinoculation, some of P. pneumotropica-infected NOD/ShiJic-scid/Jcl mice developed clinical signs of weight loss. Three of 10 P. pneumotropica-infected NOD/ShiJic-scid/Jcl mice developed clinical signs of depression, ruffled coat, and weight loss and died at 27, 34, and 59 days postinoculation. At 35 days postinoculation, almost all P. pneumotropica-infected NOD/ShiJic-scid/Jcl mice had lung abscesses. The bacteria were isolated from the upper and lower respiratory tracts, including the lungs, and blood. In contrast, P. pneumotropicainfected ICR mice exhibited no clinical signs or lesions. The bacteria were isolated from the upper, but not the lower respiratory tracts. We developed an animal model for understanding host interactions with P. pneumotropica.

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Section: Introductionmentioning

confidence: 99%

Pathogenicity of Pasteurella pneumotropica in Immunodeficient NOD/ShiJic-scid/Jcl and Immunocompetent Crlj:CD1 (ICR) Mice

et al. 2011

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“…One is the enhancement of SARS‐CoV infection by proteases produced by the host cells (17). The other is the evolution of SARS‐CoV to an extent that it can become highly infectious and pathogenic to a given species of animals to which SARS‐CoV is adapted (15, 19, 30, 31). When these two conditions are fulfilled, severe respiratory disease can be reproduced.…”

Section: Discussionmentioning

confidence: 99%

“…Mice were anesthetized with intraperitoneal administration of xylazine and ketamine and inoculated i.n. with 20 μl of Pp MaM strain (19) suspended in PBS. In some experiments, mice were administered i.n.…”

Section: Methodsmentioning

confidence: 99%

Co‐infection of respiratory bacterium with severe acute respiratory syndrome coronavirus induces an exacerbated pneumonia in mice

Ami

Nagata

Shirato

et al. 2008

Microbiology and Immunology

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SARS‐CoV grows in a variety of tissues that express its receptor, although the mechanism for high replication in the lungs and severe respiratory illness is not well understood. We recently showed that elastase enhances SARS‐CoV infection in cultured cells, which suggests that SARS development may be due to elastase‐mediated, enhanced SARS‐CoV infection in the lungs. To explore this possibility, we examined whether co‐infection of mice with SARS‐CoV and Pp, a low‐pathogenic bacterium which elicits elastase production in the lungs, induces exacerbation of pneumonia. Mice co‐infected with SARS‐CoV and Pp developed severe respiratory disease with extensive weight loss, resulting in a 33∼90% mortality rate. Mice with exacerbated pneumonia showed enhanced virus infection in the lungs and histopathological lesions similar to those found in human SARS cases. Intranasal administration of LPS, another elastase inducer, showed an effect similar to that of Pp infection. Thus, this study shows that exacerbated pneumonia in mice results from co‐infection with SARS‐CoV and a respiratory bacterium that induces elastase production in the lungs, suggesting a possible role for elastase in the exacerbation of pneumonia.

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Bacterial, Mycoplasmal, and Mycotic Infections

Weisbroth¹,

Kohn²

2020

The Laboratory Rat

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Antigenic Characterization of <I>Pasteurella pneumotropica</I>Isolated from Mice and Rats

Cited by 8 publications

References 9 publications

Pathogenicity of Pasteurella pneumotropica in Immunodeficient NOD/ShiJic-scid/Jcl and Immunocompetent Crlj:CD1 (ICR) Mice

Pathogenicity of Pasteurella pneumotropica in Immunodeficient NOD/ShiJic-scid/Jcl and Immunocompetent Crlj:CD1 (ICR) Mice

Co‐infection of respiratory bacterium with severe acute respiratory syndrome coronavirus induces an exacerbated pneumonia in mice

Bacterial, Mycoplasmal, and Mycotic Infections

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