Antigenic relationships between Caprine alphaherpesvirus 1 (CpHV-1) and Bovine alphaherpesvirus 1 (BoHV-1) and experimental CpHV-1 infection of kids and calves

Transcriptome and Proteomic Analysis Reveals Up-Regulation of Innate Immunity-Related Genes Expression in Caprine Herpesvirus 1 Infected Madin Darby Bovine Kidney Cells

“…The transcriptional and proteomics landscape in the host upon virus infection facilitates the understanding of host immune responses and defense mechanisms based on the pathogenic microorganism infection at the whole mRNA and protein level and provides new approaches to control the viral infections. It has been reported that CpHV-1 replicated efficiently in experimentally infected calves during acute infection and established latent infection, which supports the ability of these viruses to cross-infect the respective heterologous hosts [ 18 ]. Moreover, previous studies demonstrated that CpHV-1 could infect goat peripheral blood mononuclear cells, the MDBK cell line and varied human cell lines [ 14 , 15 , 16 ].…”

“…Emerging evidence has indicated that CpHV-1 could infect varied human cell lines and provide a potential candidate for oncolytic virotherapy [ 16 ]. Moreover, it was reported that CpHV-1 replicated efficiently in experimentally infected calves during acute infection and established latent infection, which supports the ability of the virus to cross-infect the respective heterologous hosts [ 17 , 18 ]. However, the extent and relevance of CpHV-1-mediated host responses and the relationship between this responses and viral pathogenicity remain poorly studied.…”

The Oncolytic Caprine Herpesvirus 1 (CpHV-1) Induces Apoptosis and Synergizes with Cisplatin in Mesothelioma Cell Lines: A New Potential Virotherapy Approach

“…The glycoprotein H (gH) is the known viral component responsible for binding to CD46 and viral entry in Human herpesvirus 6 (HHV-6) [50] and BoHV-1 [51]. Considering the homology between BoHV-1 and CpHV-1 [34], we also hypothesize a role for these molecules in determining CpHV-1 differential entry in mesothelial/mesothelioma cells. It is not possible to exclude that CpHV-1 enters in normal mesothelial MET-5A cells; however, the functional antiviral pathways or the active cell cycle checkpoint prevents viral replication.…”

“…Among these non-human wild-type OVs, caprine herpesvirus 1 (CpHV-1) is a pathogen of goats, closely related to bovine alphaherpesvirus 1 (BoHV-1), which is non-pathogenic for humans [34]. We previously demonstrated that CpHV-1 is able to replicate in different human cancer cell lines and kill them by apoptosis or autophagy [35].…”

Presence of Multiple Herpesvirus Variants in Australian Flying Foxes (Pteropus spp.)

“…Since 1996, numerous herpesviruses have been discovered and classified in chiropteran species worldwide, predominantly from the beta- and gammaherpesvirus subfamilies (Tandler 1996; Pozo et al 2016; Wada et al 2018; James et al 2020). To date the Pteropodidae are the only Chiropteran family known to host an alphaherpesvirus; this is primarily a result of limited screening during active infection or of tissue samples in which the virus establishes latent infection, such as the trigeminal ganglia (Razafindratsimandresy et al 2009; Sasaki et al 2014; Martins et al 2019; Inagaki et al 2020). Betaherpesviruses have only been classified so far in one Pteropodidae genus ( Rousettus ), and only two Pteropodidae gammaherpesviruses have been formally recorded (Jánoska et al 2011; Anthony et al 2013; Zheng et al 2015; Pozo et al 2016; Wada et al 2018).…”