Antigenotoxic effect of Xanthohumol in rat liver slices

Plazar, Janja; Filipič, Metka; Groothuis, Geny M. M.

doi:10.1016/j.tiv.2007.09.009

Cited by 50 publications

(32 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Therefore, more related mechanism studies with high LOE are needed to identify the molecular events involved in the modulations of prenylated flavonoids on certain enzymes. Paoletti et al, 2009;Pedro et al, 2005;Plazar et al, 2007Plazar et al, , 2008Zakaria et al, 2012). Two prenylflavonoids from Amyrisins showed cytotoxicity against PC-3 and DU 145 prostate cancer cells with IC 50 values of 17.5 and 23 mM, respectively (Peng et al, 2012).…”

Section: Enzyme Inhibitor and Enhancermentioning

confidence: 99%

A systematic review on biological activities of prenylated flavonoids

Chen

Mukwaya

Wong

et al. 2013

Pharmaceutical Biology

198

136

View full text Add to dashboard Cite

Context: Prenylated flavonoids are a unique class of naturally occurring flavonoids that exist especially for the plant's self-defensive strategy. This special class of flavonoids increases the bioactivities of their backbone flavonoids with non-prenylation; therefore, prenylated flavonoids have more potential to be developed and utilized. Objective: The number, position and type of the prenyl group on the flavonoids backbone structure may have close relationships with the bioactivities of flavonoids. Methods: PubMed and WEB OF KNOWLEDGEÕ were used to search articles published in English between 1 January 2002 and 31 December 2012, which discuss the structure-activity relationship between prenylated flavonoids and their bioactivities. Results: It is proposed that the prenyl-moiety makes the backbone compound more lipophilic, which leads to its high affinity with cell membranes. The prenylation brings the flavonoids with enhancement of antibacterial, anti-inflammatory, antioxidant, cytotoxicity, larvicidal as well as estrogenic activities. However, it is reported that the prenyl-moiety decreases the bioavailability and plasma absorption of prenylated flavonoids. Conclusion: The prenyl group affects the bioactivities of flavonoids in certain ways, while the action mechanisms and the structure-activity relationship as well as more in vivo studies even clinical validation trials need to be further investigated.

show abstract

Section: Enzyme Inhibitor and Enhancermentioning

confidence: 99%

A systematic review on biological activities of prenylated flavonoids

Chen

Mukwaya

Wong

et al. 2013

Pharmaceutical Biology

198

136

View full text Add to dashboard Cite

show abstract

“…As shown by numerous studies, some plant-derived natural chemicals have protective effects against genotoxicity induced by oxidative stresses (Ruberto and Baratta, 2000;Glei and Pool-Zobel, 2006;Plazar et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

Antigenotoxic and antioxidant activities of palmarosa and citronella essential oils

Sinha

Biswas²,

Mukherjee

2011

Journal of Ethnopharmacology

View full text Add to dashboard Cite

“…As shown by numerous studies, some plant-derived natural chemicals, known as secondary metabolites, have protective effects against genotoxicity induced by oxidative stresses (Glei et al 2006;Plazar et al 2008;Baratta 2000). Therefore, investigation of natural compounds has been a major research interest for the past two decades to identify and isolate plant materials for their antigenotoxic properties.…”

mentioning

confidence: 99%

Evaluation of antigenotoxicity effects of umbelliprenin on human peripheral lymphocytes exposed to oxidative stress

et al. 2008

View full text Add to dashboard Cite

The protective properties of a prenylated coumarin, umbelliprenin (UMB), on the human lymphocytes DNA lesions were tested. Lymphocytes were isolated from blood samples taken from healthy volunteers. DNA breaks and resistance to H(2)O(2)-induced damage were measured using a single-cell microgel electrophoresis technique under alkaline conditions (comet assay). Human lymphocytes were incubated in UMB (10, 25, 50, 100, 200, and 400 microM) alone or a combination of different concentrations of UMB (10, 25, 50, 100, 200, and 400 microM) and 25 microM H(2)O(2). Untreated cells, ascorbic acid (AA; 25, 50, 100, 200, and 400 microM) and H(2)O(2) (25 microM) were considered as negative control, positive control, and the standard antioxidant agent for our study, respectively. Single cells were analyzed with "TriTek Cometscore version 1.5" software. The DNA damage was expressed as percent tail DNA. UMB exhibited a concentration-dependent increase in protection activity against DNA damage induced by 25 microM H(2)O(2) (from 67.28% to 39.17%). The antigenotoxic activity of AA, in the range 0-50 microM, was greater than that of UMB. However, no significant difference (p> 0.05) in the protective activity was found between UMB and AA at concentrations of approximately higher than 50 microM.

show abstract

Antigenotoxic effect of Xanthohumol in rat liver slices

Cited by 50 publications

References 42 publications

A systematic review on biological activities of prenylated flavonoids

A systematic review on biological activities of prenylated flavonoids

Antigenotoxic and antioxidant activities of palmarosa and citronella essential oils

Evaluation of antigenotoxicity effects of umbelliprenin on human peripheral lymphocytes exposed to oxidative stress

Contact Info

Product

Resources

About