Antigenotoxic properties of two newly synthesized β‐aminoketones against N‐methyl‐N′‐nitro‐N‐nitrosoguanidine and 9‐aminoacridine‐induced mutagenesis

Öztürkcan, S. Arda; Turhan, Kadir; Turgut, Zühal; Karadayı, Mehmet; Güllüce, Medine

doi:10.1002/jbt.21414

Cited by 15 publications

(14 citation statements)

References 31 publications

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“…Noteworthy, the ability of compounds to affect mutagens simultaneously in varied ways significantly enhances antimutagenic effectiveness. Hence, searching for such multifunctionally acting antimutagens is of great importance [9].…”

Section: Multifunctionally Acting Antimutagensmentioning

confidence: 99%

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Current Trends and Future Perspectives of Antimutagenic Agents

AbdelHakem¹,

Abdelhafez²

2021

Genotoxicity and Mutagenicity - Mechanisms and Test Methods

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Mutation is the process leading to heritable changes in DNA caused mainly by internal and external factors. Recently, studies on mutagenic agents have been increased due to increasing in mutation-related disease. The antimutagenic effect is desired to prevent mutation on genes or to inactivate the mutagenic agent. It seems that the interest in antimutagenic substances displaying multiple mechanisms of action will be an important trend in the research and development of new antimutagenic compounds in the near future. Therefore, this chapter displays various possible mechanisms of action for antimutagenic agent and introduces different types of antimutagens, natural and synthetic, that are considered very important.

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Section: Multifunctionally Acting Antimutagensmentioning

confidence: 99%

“…The results showed that tannic acid can act as an anticlastogen and antimutagen in vivo [42]. (Figure 15) [9]. The antimutagenic potential of these compounds may be related to the inhibition of the production of O6-methylguanine, a product of MNNG that is related to its mutagenic effect.…”

Section: Tannic Acidmentioning

confidence: 99%

Current Trends and Future Perspectives of Antimutagenic Agents

AbdelHakem¹,

Abdelhafez²

2021

Genotoxicity and Mutagenicity - Mechanisms and Test Methods

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“…In the study conducted by Ozturkcan et al (2012), the antigenotoxic potential of two newly synthesized β-aminoketones against MNNG and 9-aminoacridine (9-AA)-induced mutagenesis was evaluated. The findings of the study provided information about chemical prevention from the toxicity of both mutagens by using selected compounds.…”

Section: Antimutagens With Multiple Mechanisms Of Actionmentioning

confidence: 99%

Antimutagenic compounds and their possible mechanisms of action

et al. 2014

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Mutagenicity refers to the induction of permanent changes in the DNA sequence of an organism, which may result in a heritable change in the characteristics of living systems. Antimutagenic agents are able to counteract the effects of mutagens. This group of agents includes both natural and synthetic compounds. Based on their mechanism of action among antimutagens, several classes of compounds may be distinguished. These are compounds with antioxidant activity; compounds that inhibit the activation of mutagens; blocking agents; as well as compounds characterized with several modes of action. It was reported previously that several antitumor compounds act through the antimutagenic mechanism. Hence, searching for antimutagenic compounds represents a rapidly expanding field of cancer research. It may be observed that, in recent years, many publications were focused on the screening of both natural and synthetic compounds for their beneficial muta/antimutagenicity profile. Thus, the present review attempts to give a brief outline on substances presenting antimutagenic potency and their possible mechanism of action. Additionally, in the present paper, a screening strategy for mutagenicity testing was presented and the characteristics of the most widely used antimutagenicity assays were described.

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“…Certain antimutagens work by blocking the mutagen binding to DNA [33]. Two synthesized β-amino ketones have demonstrated their antimutagenic action against MNNG and 9-aminoacridine (9-AA) induced mutagenicity through this mechanism [33].…”

Section: Blockage Of Mutagen Binding To the Targetmentioning

confidence: 99%

Fruits and Vegetables as Dietary Sources of Antimutagens

Gautam¹,

Saxena²,

Kumar³

2016

J Food Chem Nanotechnol

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Mutation is the process leading to heritable changes in the genetic material of an organism and caused mainly by the external factors, including chemical and physical agents, or can also occur spontaneously due to errors in DNA replication, repair, and recombination. Agents contributing to the mutagenic burden in the environment could be from industrial sources, wide spectrum applications of biocides in the agriculture, and other contaminants. As many of these mutagenic chemicals can induce severe disorders in humans including cancer and a large spectrum of inherited diseases, it is important to detect such mutagenic agents precisely and rapidly, and also look for an approach to combat them. Natural occurring dietary antimutagens primarily from health protective foods such as fruits and vegetables could provide a mechanism to counteract the deleterious effect of these mutagens. The World Health Organization (WHO) indicates that one-third of all cancer deaths are preventable and that diet is closely linked to cancer prevention. These health protective phytochemicals particularly antimutagenic ones could provide an effective solution to these concerns. The current review deals with understanding of the mutagenic events, methods of its analysis and a brief compilation of the existing scientific findings related to the dietary sources having potential to counteract the effects of the mutagenic exposures from different sources. The review would provide an opportunity to look into the science, think about the possible future perspectives and mechanism to translate the outcome of the scientific research for benefits of the mankind.

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Antigenotoxic properties of two newly synthesized β‐aminoketones against N‐methyl‐N′‐nitro‐N‐nitrosoguanidine and 9‐aminoacridine‐induced mutagenesis

Cited by 15 publications

References 31 publications

Current Trends and Future Perspectives of Antimutagenic Agents

Current Trends and Future Perspectives of Antimutagenic Agents

Antimutagenic compounds and their possible mechanisms of action

Fruits and Vegetables as Dietary Sources of Antimutagens

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