Antigens as Markers on Cultured Mammalian Cells

Franks, D.

doi:10.1111/j.1469-185x.1968.tb01107.x

Cited by 28 publications

(2 citation statements)

References 81 publications

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“…low inoculation dose, no tumour regression, absence of splenomegaly in tumour-bearing animals) does not suggest major antigenic discrepancies between the syngeneic hosts and either cell type. This and the similar transplantabilities might indicate a similar antigenicity for in v i m grown cells as for their in vivo derived origin, although the former cells may have acquired new surface antigens through genetic changes or antigen adsorption from the culture medium (Hamburger et al, 1963;Foley and Drolet, 1964;Franks, 1968;Moore et a/., 1968).…”

Section: Discussionmentioning

confidence: 98%

Influence of cultivation, trypsinization and aggregation on the transplantability of melanoma B16 cells

Hagmar

Norrby

1973

Intl Journal of Cancer

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Section: Discussionmentioning

confidence: 98%

Influence of cultivation, trypsinization and aggregation on the transplantability of melanoma B16 cells

Hagmar

Norrby

1973

Intl Journal of Cancer

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“…Whether the I and i antigens occur in human tissues such as the kidney is conjectural. Feizi and Monger (1967) could find no inhibitor of anti-I by kidney homogenates, but Franks (1968) detected both I and i antigens in aneuploid and diploid human cell lines.…”

Section: Discussionmentioning

confidence: 88%

Chronic glomerular nephritis in a man with an IgM cold autoantibody of anti-I specificity and a cold lymphocytotoxic antibody

Bailey¹,

El-Maghraby²,

Balfour³

et al. 1972

J Clin Pathol

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The aetiological processes involved in the majority of patients with chronic glomerular nephritis are unknown.The case reported here is that of a young man where it is possible that the glomerular injury was secondary to circulating atypical cold antibodies with or without the agency of complement.Case History R.R., a 24-year-old Ceylonese engineering student, was known to have had proteinuria and intermittent ankle oedema for nine years. He had been treated with short courses of corticosteroids and more recently with hypotensive therapy for mild hypertension. For the past four years he had noted polyuria and nocturia with increased thirst. At the time of admission to this hospital his major complaint was of a painful flitting arthralgia of most of the small joints, particularly of the hands, wrists, and elbows. He was also suffering severe muscle cramps.On examination he was an intelligent, healthy looking man with moderate pallor. He was mildly hypertensive. A trace of ankle oedema but no sacral oedema was noted. The liver was not palpable but the spleen was firm, tender and palpable 3 fingerbreadths below the costal margin. INVESTIGATIONSAt presentation the haemoglobin was 9-1 g/100 ml, PCV 27-5 %, WBC 4 800/cmm, reticulocytes 2%,

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Tumor-specific membrane antigens in established cell lines from gliomas

Wahlström

Linder

Saksela

et al. 1974

Cancer

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Rabbits were immunized with lyophilized glioblastoma multiforme tissue from one tumor. After 4 months, when the animals suffered from severe encephalomyelitis, their sera were collected and absorbed with lyophilized human serum, and lung, liver, kidney, placenta, and brain, as well as fresh HeLa cells, until they reacted only with cell lines cultured from malignant gliomas in indirect immunofluorescence tests. The immunofluorescent staining of the glioma cell lines revealed three distinct patterns of membrane fluorescence. In some lines a delicate segmentary type of fluorescence was seen only at the cell margin; others showed a coarse brush‐like pattern. One glioma line had a fine fibrillary membrane fluorescence which extended to the thinnest dendritic extensions, characteristic of this line. Each line displayed only one and always the same type of fluorescence in repeated tests and different passages in vitro. In a coded series of 23 cell lines derived from different normal and neoplastic tissues, all of the 15 glioma lines included were correctly identified by their tumor‐specific membrane antigens. The nature of the glioma‐specific antigens as compared with tumor‐specific antigens within other histogenetic groups of neoplasms is discussed.

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Antigens as Markers on Cultured Mammalian Cells

Cited by 28 publications

References 81 publications

Influence of cultivation, trypsinization and aggregation on the transplantability of melanoma B16 cells

Influence of cultivation, trypsinization and aggregation on the transplantability of melanoma B16 cells

Chronic glomerular nephritis in a man with an IgM cold autoantibody of anti-I specificity and a cold lymphocytotoxic antibody

Tumor-specific membrane antigens in established cell lines from gliomas

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