Antigiardial activity of flavonoids from leaves of Aphelandra scabra

Hernández-Bolio, Gloria Ivonne; Torres-Tapia, Luis W.; Moo-Puc, Rosa; Peraza‐Sánchez, Sergio R.

doi:10.1016/j.bjp.2015.04.004

Cited by 9 publications

(5 citation statements)

References 30 publications

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“…In addition, cirsimaritin, a flavone isolated from Aphelandra scabra (Vahl) Sm., has also been described as a potent giardicidal compound (3.8 μM), and epi-catechin isolated from Rubus coriifolius Liebm. has been reported to display amoebicidal (IC 50 = 6.5 μM) and giardicidal (5.5 μM) activity (Alanís et al 2003;Hernández-Bolio et al 2015). Cirsimaritin and epi-catechin comply with the empirical structural rules for antiprotozoal activity against E. histolytica and G. lamblia.…”

Section: Resultsmentioning

confidence: 83%

Salvia connivens, a Source of Bioactive Flavones with Amoebicidal and Giardicidal Activity

Bautista

Calzada

Yépez‐Mulia

et al. 2020

Rev. Bras. Farmacogn.

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Salvia connivens Epling, Lamiaceae, is an annual herbaceous plant used as a traditional medicine in Mexico for the treatment of diarrhea, which out can be caused by bacterial, viral, and protozoal infections, as well as toxins mainly. Mexican medicinal plants with anti-diarrheic activity represent a source of potential antiprotozoal agents. The phytochemical isolation of the constituents of an acetone-soluble extract led to the isolation of the known flavonoids: eupatorin, cirsiliol, and nuchensin. The structures of these compounds were elucidated by the analysis of their NMR and MS data. Nuchensin displayed potent antiprotozoal activity against Entamoeba histolytica (IC 50 0.072 ± 0.006 μM) and Giardia lamblia (IC 50 0.118 ± 0.006 μM), which was comparable to metronidazole.

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Section: Resultsmentioning

confidence: 83%

Salvia connivens, a Source of Bioactive Flavones with Amoebicidal and Giardicidal Activity

Bautista

Calzada

Yépez‐Mulia

et al. 2020

Rev. Bras. Farmacogn.

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“…In conclusion, lignans 1 – 8 and flavonol 9 represent two well-known classes of plant secondary metabolites [ 67 , 68 ]. The well-studied flavonoid class of natural products such as 9 display a broad range of biological activity including antiparasitic activity [ 68 , 69 ]. Likewise, lignan natural products have received strong interest and have been intensely studied due to their broad clinically relevant biological activity, including: antioxidant, antiviral, antibacterial, immunosuppressive, anti-inflammatory, and anticancer properties [ 67 , 70 ].…”

Section: Discussionmentioning

confidence: 99%

Larrea tridentata: A novel source for anti-parasitic agents active against Entamoeba histolytica, Giardia lamblia and Naegleria fowleri

Bashyal

Trpta

et al. 2017

PLoS Negl Trop Dis

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Protozoan parasites infect and kill millions of people worldwide every year, particularly in developing countries where access to clean fresh water is limited. Among the most common are intestinal parasites, including Giardia lamblia and Entamoeba histolytica. These parasites wreak havoc on the epithelium lining the small intestines (G. lamblia) and colon (E. histolytica) causing giardiasis and amebiasis, respectively. In addition, there are less common but far more deadly pathogens such as Naegleria fowleri that thrive in warm waters and infect the central nervous systems of their victims via the nasal passages. Despite their prevalence and associated high mortality rates, there remains an unmet need to identify more effective therapeutics for people infected with these opportunistic parasites. To address this unmet need, we have surveyed plants and traditional herbal medicines known throughout the world to identify novel antiparasitic agents with activity against G. lamblia, E. histolytica, and N. fowleri. Herein, we report Larrea tridentata, known as creosote bush, as a novel source for secondary metabolites that display antiparasitic activity against all three pathogens. This report also characterizes the lignan compound classes, nordihydroguairetic acid and demethoxyisoguaiacin, as novel antiparasitic lead agents to further develop more effective drug therapy options for millions of people worldwide.

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“…The reported antiparasitic (antigiardial, antiplasmodial) and molluscicidal activities of A. coriaria could be due to the secondary metabolites identified in its extracts. For instance, flavonoids have been indicated to be effective in vitro as antigiardial agents (Barbosa, Calzada, & Campos, 2007;Hernández-Bolio, Torres-Tapia, Moo-Puc, & Peraza-Sánchez, 2015) through proapoptotic induction of cell death (Argüello-García, Calzada, García-Hernández, Chávez-Munguía, & Velázquez-Domínguez, 2020). On the other hand, antiplasmodial and antimycoplasmal activities of plant extracts are usually elicited by alkaloids, terpenoids, flavonoids, coumarins, phenolics, quinones and steroids (Bekono et al, 2020;Uzor, 2020) which have been identified A. coriaria extracts.…”

Section: Antigiardial Antiplasmodial and Molluscicidal Activitiesmentioning

confidence: 99%

Albizia coriaria Welw ex Oliver: a review of its ethnobotany, phytochemistry and ethnopharmacology

Omara

Kiprop

Kosgei

2021

ADV TRADIT MED (ADTM)

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Albizia coriaria Welw ex. Oliver have a long history of ethnomedicinal use in the management of various diseases in Africa. Due to the frequent use of its stem bark and roots in traditional phytotherapy, the species is getting threatened in its distributional ranges. The current review was sought to document information on the ethnobotany, phytochemicals and pharmacology of different parts of A. coriaria, so as to highlight the gaps thereof for future studies. Data retrieved revealed that medicinal uses of A. coriaria have been reported for both human and veterinary ailments. Though the bark is the most commonly used, different parts of the plant are used to prepare herbal remedies for treatment of malignancies, odontological, dermatological, respiratory, gastrointestinal, reproductive, central nervous system infections/conditions and ailments. Preliminary phytochemical screening has indicated the presence of saponins, tannins, alkaloids, flavonoids, phenols, terpenes, cardiac glycosides and steroids as the major secondary metabolites in the stem bark and leaves. Like for other Albizia species, at least six triterpenoidal saponins have been characterized in organic extracts of A. coriaria stem bark and roots. Extracts and some pure compounds from A. coriaria stem bark, leaves and roots have exhibited antiproliferative (cytotoxic), antiplasmodial, molluscicidal, antigiardial, antioxidant, anti-inflammatory and antimicrobial activities. Further research should evaluate pharmacological properties such as antisnake venom, aphrodisiac, antiviral and antimycobacterial activities of the different parts of A. coriaria claimed in traditional folklore. In-depth studies on the pharmacokinetics, in vivo and clinical research utilizing extracts and isolated compounds from A. coriaria are required.

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Antigiardial activity of flavonoids from leaves of Aphelandra scabra

Cited by 9 publications

References 30 publications

Salvia connivens, a Source of Bioactive Flavones with Amoebicidal and Giardicidal Activity

Salvia connivens, a Source of Bioactive Flavones with Amoebicidal and Giardicidal Activity

Larrea tridentata: A novel source for anti-parasitic agents active against Entamoeba histolytica, Giardia lamblia and Naegleria fowleri

Albizia coriaria Welw ex Oliver: a review of its ethnobotany, phytochemistry and ethnopharmacology

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