Antiglobulins and Human Disease

Goldberg, L.S.; Fudenberg, H.H.

doi:10.1159/000466606

Cited by 5 publications

(6 citation statements)

References 34 publications

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“…and Fc, but not Fab or light chains bound to glomeruli reactive with FA IgG. This spectrum of reactivity is consistent with that of most rheumatoid factors (40). Although denatured IgG or IgG complexed to antigen is generally required to stimulate formation of rheumatoid factors (45), once these antiglobulins are formed they will frequently react with both native and heat-aggregated IgG molecules (41,42,46,47).…”

Section: Fc But Not Fab' Localize To the Periphery Of Theglomerular Csupporting

confidence: 71%

“…Although denatured IgG or IgG complexed to antigen is generally required to stimulate formation of rheumatoid factors (45), once these antiglobulins are formed they will frequently react with both native and heat-aggregated IgG molecules (41,42,46,47). Most commonly they are specific for antigenic determinants within the Fc piece (40,43,44,46), and only rarely react with antigens in Fab or light chains (40).…”

Section: Fc But Not Fab' Localize To the Periphery Of Theglomerular Cmentioning

confidence: 99%

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Renal localization of antiglobulins in glomerulonephritis and after renal transplantation

Rossen

Rickaway

Reisberg

et al. 1977

Arthritis & Rheumatism

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Localization of fluorescein‐conjugated heat‐aggregated IgG (FA IgG) was demonstrated by immunofluorescence in renal glomeruli of 16 of 69 patients with glomerulonephritis. FA IgG bound more frequently in kidney biopsies from patients with diffuse glomerulonephritis and depressed renal function, and localized selectively in glomeruli that contained heavy deposits of IgM, C3, and C4. The factors that caused FA IgG to bind were specifically reactive with the Fc piece of the IgG molecule and were resistant to 56°C heat for 30 minutes. Localization of FA IgG in the kidney did not correlate with the presence of soluble immune complexes or detectable antiglobulin antibodies in the sera. Binding of FA IgG was also seen in glomeruli and arteries of 18 of 21 kidney allografts studied at the time of impending rejection. But the factors responsible for binding FA IgG in the allografts were heat labile and thus could have been Clq. Although the role of these “antiglobulins” in the immunobiology of glomerulonephritis remains unknown, the fact that they occurred mainly in patients with relatively severe glomerular injury suggests that they could play some part in promoting renal glomerular injury.

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Section: Fc But Not Fab' Localize To the Periphery Of Theglomerular Csupporting

confidence: 71%

Section: Fc But Not Fab' Localize To the Periphery Of Theglomerular Cmentioning

confidence: 99%

Renal localization of antiglobulins in glomerulonephritis and after renal transplantation

Rossen

Rickaway

Reisberg

et al. 1977

Arthritis & Rheumatism

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“…There had been recent interest in searching for circulating anti-Ig that could play a role in the pathogenesis of several lymphoproliferative (12,19,20) and autoimmune diseases (21). Several patients with selective IgA deficiency were found to have in their serum anti-IgMI of the IgG class (22,23).…”

Section: Methodsmentioning

confidence: 99%

Comparative Study of Bone Marrow and Blood B Cells in Infantile and Acquired Agammaglobulinemia

Abdou¹,

Casella²,

Abdou³

et al. 1973

J. Clin. Invest.

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“…The more frequent occurrence of 'non-specific' antibodies reported in this study appears to reflect antibody stimulation of a different kind than 'specific' anti-Gm or anti-Inv. In a recent review on the significance of antiglobulin, GOLDBERG and FUDENBERG [4] concluded that antiglobulins are a heterogenous group of antibodies possessing specificities for a variety of native, altered or enzymatically exposed sites on the y-globulin. Their presence has been reported in a number of diseases but little is known regarding their biological significance.…”

Section: Discussionmentioning

confidence: 99%

A Comparative Study of Antiglobulin Antibodies and Residual Anti-D Between Recipients of Intramuscular Anti-D Immunoglobulin and Intravenous Plasma Anti-D

Vos¹,

Shapiro²,

Burgess³

et al. 1973

Vox Sanguinis

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The incidence of ‘specific’ and ‘non-specific’ antiglobulin antibodies was determined among 648 multiparous females, 213 recipients of intramuscular anti-D immunoglobulin and 221 recipients of intravenous plasma anti-D. Results obtained six months after the administration of anti-D showed that the formation of ‘specific’ anti-Gm or anti-Inv was no greater in recipients of anti-D immunoglobulin or plasma anti-D than in the controls. The incidence of ‘non-specific’ antiglobulins increased from an expected 5% among recipients of intravenous plasma anti-D to almost 25% in mothers given intramuscular anti-D immunoglobulin. It is suggested that the raised ‘non-specific’ antiglobulins may be provoked by a residue of aggregated Y-globulin components which is known to be present in preparations of Cohn fraction II. Six months after the passive administration of Rh antibodies residual anti-D activity was more, often observed in recipients of intramuscular anti-D immunoglobulin than in recipients of plasma anti-D.

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Antiglobulins and Human Disease

Cited by 5 publications

References 34 publications

Renal localization of antiglobulins in glomerulonephritis and after renal transplantation

Renal localization of antiglobulins in glomerulonephritis and after renal transplantation

Comparative Study of Bone Marrow and Blood B Cells in Infantile and Acquired Agammaglobulinemia

A Comparative Study of Antiglobulin Antibodies and Residual Anti-D Between Recipients of Intramuscular Anti-D Immunoglobulin and Intravenous Plasma Anti-D

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