Antiglycation activity of lipophilized epigallocatechin gallate (EGCG) derivatives

Wang, Mingfu; Zhang, Xinchen; Zhong, Ying; Perera, Nishani; Shahidi, Fereidoon

doi:10.1016/j.foodchem.2015.06.033

Cited by 50 publications

(31 citation statements)

References 19 publications

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“…Scientists have described some derivatives through replacing the different hydrogens on the rings of A, B and D of EGCG structure, such as methylated [ 97 , 98 ], acylated [ 99 , 100 , 101 , 102 ], esterified [ 103 , 104 ], and glycosylated [ 105 , 106 , 107 ] EGCG, in research relating to other activities of GTCs. From the existing research data, it seems that the modifications on the rings of B and D, especially D show more effectivity.…”

Section: Discussionmentioning

confidence: 99%

A Review of the Antiviral Role of Green Tea Catechins

2017

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Over the centuries, infectious diseases caused by viruses have seriously threatened human health globally. Viruses are responsible not only for acute infections but also many chronic infectious diseases. To prevent diseases caused by viruses, the discovery of effective antiviral drugs, in addition to vaccine development, is important. Green tea catechins (GTCs) are polyphenolic compounds from the leaves of Camellia sinensis. In recent decades, GTCs have been reported to provide various health benefits against numerous diseases. Studies have shown that GTCs, especially epigallocatechin-3-gallate (EGCG), have antiviral effects against diverse viruses. The aim of this review is to summarize the developments regarding the antiviral activities of GTCs, to discuss the mechanisms underlying these effects and to offer suggestions for future research directions and perspectives on the antiviral effects of EGCG.

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Section: Discussionmentioning

confidence: 99%

A Review of the Antiviral Role of Green Tea Catechins

2017

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“…To increase the application areas and efficacy of green tea EGCG, Zhong and Shahidi (2011;2015) for the first-time esterified hydroxyl groups of EGCG with molecules such as stearic acid (SA; 18:0), eicosapentaenoic acid (EPA; 20:5) and docosahexaenoic acid (DHA; 22:6) in a patented process. Several promising beneficiary effects of lipophilic EGCG derivatives such as antioxidant, antiviral, anti-glycation and anti-carcinogenic effects were reported (Zhong and Shahidi, 2011;Wang et al, 2016). Myers, Fuller and Yang (2013) reported that EGCG esters could also naturally exist in green tea.…”

Section: Introductionmentioning

confidence: 99%

Epigallocatechin gallate (EGCG) esters with different chain lengths fatty acids and their antioxidant activity in food and biological systems

Perera¹,

Ambigaipalan²,

Shahidi³

2018

Journal of Food Bioactives

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Ester derivatives of epigallocatechin gallate (EGCG) were prepared by acylation with different chain lengths acyl chlorides, namely acetyl chloride, C2:0; propionyl chloride, C3:0; caproyl chloride, C6:0; capryloyl chloride, C8:0; lauroyl chloride, C12:0; stearoyl chloride, C18:0; and docosahexaenoyl chloride, C22:6. The resultant products, mainly tetra-esters, were purified and their lipophilicity, radical scavenging ability and antioxidant activities in food (bulk oil, β-carotene/linoleate emulsion and ground meat) and biological systems (LDL cholesterol and DNA) evaluated. The lipophilicity of the esters increased with increasing chain length of the acyl group and also led to the enhancement of their antioxidant properties. These findings strongly suggest that the EGCG ester derivatives have great potential as lipophilic alternatives to the water-soluble EGCG.

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“…The current study reports a potent anti-glycation activity of EGCG on inhibiting MG-induced Tau glycation. EGCG modified with fatty acids have been shown to posses anti-glycation activity in vitro (58). EGCG is also known to posses the carbonyl trapping property with the ratio of 3 moles of EGCG per mole of MG (59).…”

Section: Discussionmentioning

confidence: 99%

A green tea polyphenol Epigallocatechin-3-gallate modulates Tau Post-translational modifications and cytoskeletal network

Chinnathambi

2020

Preprint

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Background: Alzheimer's disease is a type of dementia denoted by progressive neuronal death due to the accumulation of proteinaceous aggregates of Tau. Post-translational modifications like hyperphosphorylation, truncation, glycation, etc. play a pivotal role in Tau pathogenesis. Glycation of Tau aids in paired helical filament formation and abates its microtubule-binding function. The chemical modulators of Tau PTMs, such as kinase inhibitors and antibody-based therapeutics, have been developed, but natural compounds, as modulators of Tau PTMs are not much explored. Methods: We applied biophysical and biophysical techniques like fluorescence kinetics, SDS-PAGE, western blot analysis and transmission electron microscopy to investigate the impact of EGCG on Tau glycation in vitro. The effect of glycation on cytoskeleton instability and its EGCG-mediated rescue were studied by immunofluorescence in neuroblastoma cells.

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Antiglycation activity of lipophilized epigallocatechin gallate (EGCG) derivatives

Cited by 50 publications

References 19 publications

A Review of the Antiviral Role of Green Tea Catechins

A Review of the Antiviral Role of Green Tea Catechins

Epigallocatechin gallate (EGCG) esters with different chain lengths fatty acids and their antioxidant activity in food and biological systems

A green tea polyphenol Epigallocatechin-3-gallate modulates Tau Post-translational modifications and cytoskeletal network

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