Antiglycation and anti‐oxidant efficiency of carnosine in the plasma and liver of aged rats

Bingül, İlknur; Yılmaz, Zülbiye; Aydın, Abdurrahman Fatih; Çoban, Jale; Doğru‐Abbasoğlu, Semra; Uysal, Müjdat

doi:10.1111/ggi.13126

Cited by 19 publications

(13 citation statements)

References 31 publications

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“…Kuloglu et al (19) reported that rats that received carbon tetrachloride exhibited significantly higher ALT and AST levels than rats administered carbon tetrachloride and CAR. Similarly, Tokyol et al (24) reported increased ALT and AST levels after hepatic I/R, which suggested free-radical-induced hepatic tissue damage; and these increases were ameliorated by CAR. In our study, the increases in AST and ALT levels caused by I/R damage were significantly ameliorated by CAR pretreatment.…”

Section: Discussionmentioning

confidence: 87%

Karaciğer İskemisinde Karnozinin Koruyucu Etkisi

Şahin

Uylaş²,

Şahıntürk³

et al. 2019

Osmangazi̇ Journal of Medicine

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This study investigated the antioxidant effects of carnosine (CAR) in rats exposed to hepatic ischemia-reperfusion (I/R) injury using biochemical and histopathological evaluation. Twenty-four Sprague-Dawley male rats weighing 200-250 g were used to investigate the antioxidant effects of carnosine on the liver. Rats were randomly divided into the following groups: sham (control) group (G1), hepatic I/R group (G2), and hepatic I/R treated with 100 mg/kg CAR group (G3). Rats in the control group underwent only laparotomy and catheterisation. Rats in the other groups received 2 h of reperfusion following 1 h of hepatic ischemia by hepatic artery clamping after laparotomy. Rats in the treatment group received an intraperitoneal (i.p.) injection of 100 mg/kg CAR 60 min before hepatic artery clamping. All rats were monitored for 48 h. Then, they were sacrificed and blood samples were obtained for determination of aspartate transaminase (AST), alanine transaminase (ALT), and liver tissue samples were taken for malondialdehyde (MDA), glutathione (GSH) and catalase (CAT) levels, and for the histopathologic examination as well. Serum AST, ALT and tissue MDA levels were significantly decreased and GSH and CAT levels were significantly higher in the CARtreated group compared to the non-treated group exposed to only I/R injury. Histopathological damage was significantly less in rats which received carnosine than that of non-treated group. We concluded that 100 mg/kg CAR may be effective in preventing the oxidative damage in liver tissue due to I/R injury.

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Section: Discussionmentioning

confidence: 87%

Karaciğer İskemisinde Karnozinin Koruyucu Etkisi

Şahin

Uylaş²,

Şahıntürk³

et al. 2019

Osmangazi̇ Journal of Medicine

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“…There is evidence, first obtained more than 25 years ago, that carnosine delays senescence, extends lifespan and even rejuvenates cultured human lung fibroblasts [5]. Subsequent studies revealed that carnosine (i) can delay ageing and/or related phenomena in some animal models [6][7][8][9][10], (ii) possesses anti-oxidant and anti-glycating activities [11][12][13][14][15], (iii) possesses anti-inflammatory properties [16][17][18][19][20], (iv) is protective towards lung injury [21][22][23], (v) can decrease the infectivity of RNA viruses Zika, Denge [24] and influenza [25], (vi) is an inhibitor of CD26 (also known and dipeptidyl peptidase IV (DPP4) [26,27] and ACE-2 (angiotensin converting enzyme 2) [28,29], i.e. the cell receptors to which COVID-19 attaches to ensure infection [30,31], (vii) can complex with zinc ions to form polaprezinc [32]; it has been reported that zinc ions can inhibit COVID-19 RNA polymerase thus suppressing viral replication [33].…”

Section: Carnosine Aging and Covid-19mentioning

confidence: 99%

“…Childhood trauma has been linked to psychopathology, accelerated aging-related DNA methylation [42] and schizophrenia [43]. Furthermore, erythrocytes from schizophrenics show evidence of increased aging-related protein glycation [44], while dietary carnosine supplementation has been shown to produce beneficial effects in schizophrenics [45], possibly due, in part, to carnosine's anti-glycating activity [11,12].…”

Section: Carnosine and Bloodmentioning

confidence: 99%

COVID-19 and Senotherapeutics: Any Role for the Naturally-occurring Dipeptide Carnosine?

Hipkiss¹

2020

Aging and disease

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It is suggested that the non-toxic dipeptide carnosine (beta-alanyl-L-histidine) should be examined as a potential protective agent against COVID-19 infection and inflammatory consequences especially in the elderly. Carnosine is an effective anti-inflammatory agent which can also inhibit CD26 and ACE2 activity. It is also suggested that nasal administration would direct the peptide directly to the lungs and escape the attention of serum carnosinase.

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“…The ingestion of carnosine was also determined to exert a therapeutic effect on chronic metabolic disorders, a property which is likely associated with its potent anti-oxidative, anti-glycation, Carnosine-a natural bioactive dipeptide Xing et al Aged rats ↓AGE and MDA; ↓Protein carbonyl and advanced oxidized protein products Bingül et al, 2017 Anti-inflammatory Caco-2 cells ↓IL-8 secretion Son et al, 2008 Male Balb/cA mice ↓c-reactive protein (CRP), IL-6 tumor and TNF-α Liu et al, 2008 Balb/cA mice ↓IL-6, TNF-α, and MCP-1 Yan et al, 2009 Mice ↓TNF-α and IL-6 levels Tsai et al, 2010 Elderly people ↓MCP-1 and IL-8 Hisatsune et al, 2016 Sepsis-induced male albino rats.…”

Section: Heath Benefitsmentioning

confidence: 99%

Carnosine—a natural bioactive dipeptide: bioaccessibility, bioavailability and health benefits

Xing¹,

Chee²,

Zhang³

et al. 2019

Journal of Food Bioactives

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Carnosine is a natural dipeptide synthesized by both vertebrate and invertebrate organisms and has functional properties that are specific to muscle and excitable tissues. Recent in vivo and in vitro studies have shown that carnosine presents metal chelating and antioxidant activities and has the ability to inhibit protein carbonylation and glycoxidation. This review describes the health benefits of carnosine in relation to its bioaccessibility, bioavailability and biochemical properties as well as providing the current state-of-the-art knowledge on the potential use of carnosine as a nutraceutical. The therapeutic potential of carnosine has also been investigated by a number of preclinical and clinical studies for diseases such as diabetes and its associated complications, as well as fatigue, ageing, and some neurological disorders. Altogether the current literature provides supportive evidence on the use of carnosine as a natural dietary supplement with significant health boosting efficiency and without any side effects.

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Antiglycation and anti‐oxidant efficiency of carnosine in the plasma and liver of aged rats

Abstract: These results clearly show that CAR might be useful for decreasing glycoxidant stress in aged rats. Geriatr Gerontol Int 2017; 17: 2610-2614.

Cited by 19 publications

References 31 publications

Karaciğer İskemisinde Karnozinin Koruyucu Etkisi

Karaciğer İskemisinde Karnozinin Koruyucu Etkisi

COVID-19 and Senotherapeutics: Any Role for the Naturally-occurring Dipeptide Carnosine?

Carnosine—a natural bioactive dipeptide: bioaccessibility, bioavailability and health benefits

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