Antihepatotoxic Activity of<i>Chelidonium majus</i>

Mitra, Soumita; Gole, Mukul K; Samajdar, K.; Sur, Runa; Chakraborty, Biswajit

doi:10.3109/13880209209053974

Cited by 17 publications

(6 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Hepatoprotective Activity Animal studies: The ethanolic whole extract exerted marked hepatoprotection against carbon tetrachloride toxicity in two studies on rats, indicated by a reduction in the number of necrotic cells, a prevention of fibrotic changes, and decreased activities of transaminases and bilirubin [37,38]. It was also efficient in combating p-dimethylaminoazobenzene-induced hepatocarcinogenesis in mice [39].…”

Section: Description Of Chelidonium Majus In Traditional Chinesementioning

confidence: 99%

Chelidonium majus – an Integrative Review: Traditional Knowledge versus Modern Findings

Gîlcă

Găman

Panait

et al. 2010

Forsch Komplementmed

115

View full text Add to dashboard Cite

Chelidonium majus L. (family Papaveraceae), or greater celandine, is an important plant in western phytotherapy and in traditional Chinese medicine. Crude extracts of C. majus as well as purified compounds derived from it exhibit a broad spectrum of biological activities (antiinflammatory, antimicrobial, antitumoral, analgesic, hepatoprotective) that support some of the traditional uses of C. majus. However, herbal medicine also claims that this plant has several important properties which have not yet been scientifically studied: C. majus is supposed to have diuretic, antitussive and eye-regenerative effects. On the other hand, C. majus also has scientifically proven effects, e.g. anti-osteoporotic activity and radioprotection, which are not mentioned in traditional sources. Moreover, recent controversy about the hepatoprotective versus hepatotoxic effects of Chelidonium majus has renewed the interest of the medical community in this plant. This review is intended to integrate traditional ethno-medical knowledge and modern scientific findings about C. majus in order to promote understanding of its therapeutic actions as well as its toxic potential.

show abstract

Section: Description Of Chelidonium Majus In Traditional Chinesementioning

confidence: 99%

Chelidonium majus – an Integrative Review: Traditional Knowledge versus Modern Findings

Gîlcă

Găman

Panait

et al. 2010

Forsch Komplementmed

115

View full text Add to dashboard Cite

show abstract

“…Greater celandine (Chelidonium majus ) is a medicinal poppy (Bone, 1996) with beneficial antihepatotoxic and meanwhile controversial effects on liver (Duke, 1985;Mitra et al, 1992;. It is rich in alkaloids (Gu et al, 2010), mainly chelidonin, a naphtofenantridin derivative which stimulates the enzymatic production in liver and pancreas, it is colecystokinetic and antispastic (Gilca et al, 2010;Hriscu et al, 1980).…”

Section: Introductionmentioning

confidence: 99%

Comparative Fingerprint and Extraction Yield of Medicinal Herb Phenolics with Hepatoprotective Potential, as Determined by UV-Vis and FT-MIR Spectroscopy

Zavoi

Fetea

Ranga

et al. 2011

Not Bot Hort Agrobot Cluj

View full text Add to dashboard Cite

The present study was aimed to compare the polyphenolic composition of six medicinal herbs, from wild flora of Romania. The plants investigated, Cynara scolimus (artichoke), Taraxacum officinalis (dandelion), Chelidonium majus (celandine), Hypericum perforatum (St. John's wort), Silybum marianum (Mary thistle) and Lycopodium clavatum (Wolf 's claw) are known, to have hepatoprotective action. Using in parallel glycerol-water, ethanol-water and methanol, the solvent-dependence of the extract fingerprint and composition in bioactive molecules was studied by UV-Vis and Infrared (FT-MIR) spectrometry. The extraction yields, calculated as an extraction factor (EF) were superior in acidic methanol comparative to glycerin and ethanol, favorising the increase in phenolic acids against flavonoid derivatives . Based on the differences of polarity between the three solvents used, higher EF values were obtained for dandelion, artichoke, celandine and St. John wort, more rich in phenolic acids than flavonoids. Mary thistle and Wolf 's claw had lower concentrations of phenolics, but higher content of lignans and terpenoids. Based on the FT-MIR peaks from 8 regions, for each plant extract, has been determined the fingerprint region between 900 and 1500 cm -1 and identified the specific functional groups. A good, significant correlation was found between the concentration of total phenolics calculated by UV-Vis spectrometry and FTIR methods, after calibration with gallic acid. The value of the MIR signal at 1743 cm -1 may be considered a good indicator of phenolics concentration in such extracts. Combined UV-Vis and FTIR spectroscopy are recommended as rapid and reliable tools to investigate the fingerprint and to predict the composition of medicinal plants or to evaluate the quality and authenticity of different standardized formulas.

show abstract

“…In carbon tetrachloride induced hepatotoxicity, biochemical recovery achieved with C. mujus was reported previously (Mitra et al, 1992). The present study was undertaken to clarify the underlying aspects of tissue recovery with different doses of C. mujus, under the same experimental conditions as reported earlier.…”

Section: Introductionmentioning

confidence: 61%