No abstract

Aphanamixis polystachya is a traditional medicinal plant of the Meliaceae family in India. A crude ethanolic extract of the leaf of this plant shows a beneficial effect on toxic liver injury. Its antihepatotoxic activity was evaluated on carbon tetrachloride (CCl4)-induced liver injury in a rat model. The assessment of hepatoprotective activity was evaluated by measuring the activities of aspartate aminotransferase (ASAT), alanine aminotransferase (ALAT), alkaline phosphatase (ALP), acid phosphatase (ACP) and lactate dehydrogenase (LDH), serum total bilirubin and albumin and histology of the liver. The crude leaf extract significantly inhibits the enhanced ASAT, ALAT, ALP, ACP and LDH activities released from the CCl4-intoxicated animals. It also ameliorated the depressed value of serum albumin and the enhanced value of total bilirubin in plasma caused by CCl4 intoxication. The study showed that the crude ethanolic extract from A. polystachya leaves provided protection against acute carbon tetrachloride-induced liver damage.

No abstract

A high potency of Lycopodium clavatum Linn. (200th centesimal potency) is tested for its hepatoprotective action against carbon tetrachloride-induced hepatic damage in rat. It has been established from biochemical and histopathological studies that at least 4 doses of Lycopodium 200 can control the CCl4-induced alteration of plasma levels of aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, acetylcholinesterase, lactate deyhydrogenase, bilirubin and urea. Protective action of the drug has also been confirmed by microanatomical studies on hepatic tissues.