H<scp>EPATOPROTECTIVE</scp>E<scp>FFECT OF</scp><i>A<scp>MOORA ROHITUKA</scp></i>

Gole, Mukul K; Dasgupta, Sanchari; Sur, Runa; Ghosal, Jharna

doi:10.1080/09251619708951275

Cited by 5 publications

(2 citation statements)

References 17 publications

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“…The bark of the plant is widely used for the treatment of liver and spleen diseases, rheumatism and tumors 18,19 and also the bark has strong antimicrobial and astringent activities 20 . Beside these heapatoprotective 21 , antifeedant, repellant 22 , cytotoxic 23 , antioxidant and thrombolytic 17 activity of different parts of the plant are also established. Though there are lots of data in the literature of this plant but as far I know no study was found regarding the investigation of anthelmintic and cytotoxic activities of the bark extract of Aphanamixis polystachya (Wall.)…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Cytotoxic and Anthelmintic Activities of Bark Extract of Aphanamixis Polystachya (Wall.)

Tanveer¹,

Karmakar²,

Banik³

et al. 2013

Int. Res. J. Pharm.

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Aphanamixis polystachya (Wall.) belongs to the family Meliaceae and it is extensively used in folkloric medicine of Bangladesh, for the treatment of various disorders. This evaluating study of methanolic extract of Aphanamixis polystachya bark was conducted to investigate the cytotoxicity, using brine shrimp lethality as test method as well as anthelmintic activity with the determination of time of paralysis and death using earthworm (Pheritima posthuma) at four different concentrations. The study confirmed that the methanolic extract of the bark of Aphanamixis polystachya possess mild cytotoxic activity (LC50=26.01±0.325 μg/ml) in comparison to the standard drug vincristine sulphate (LC50=0.839±0.013 μg/ml). On the other hand methanolic extract showed better anthelmintic activity as it required less time for paralysis and death comparing with the standard drug albendazole (concentration 10 mg/ml). At concentrations 10, 20, 40 and 60 mg/ml methanolic extract showed paralysis at mean time of 35.66± 0.72, 32.66±0.47, 27.66±0.72 and 25.66±0.27 and death at 52.33±0.72, 48.33±0.47, 40.00± 0.98 and 38.33±0.27 minutes, respectively. Whereas the standard drug albendazole showed paralysis and death at 56.20±0.20 and 77.40±0.24 minutes respectively. Thus, further studies are suggested to isolate the key compounds responsible for the cytotoxic and anthelmintic activities and also to conduct these tests using in vivo procedures.

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Section: Introductionmentioning

confidence: 99%

Evaluation of Cytotoxic and Anthelmintic Activities of Bark Extract of Aphanamixis Polystachya (Wall.)

Tanveer¹,

Karmakar²,

Banik³

et al. 2013

Int. Res. J. Pharm.

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“…The stem barks of Aphanamixis polystachya is used traditionally in treatment of tumors, cancer, skin and spleen diseases, leprosy, diabetes, opthalmopathy, intestinal worm, jaundice and rheumatism [2] . The hepatoprotective activity [3] , antimicrobial, antiviral and antibacterial activity of isolated limonoid rohitukin [4,5] and cytotoxicity of amoorastatin were also established [6] . Aphanamixis polystachya has disclosed the presence of Aphanmixis a triterpenes [7] , tetranortriterpenoid i.e.…”

Section: Introductionmentioning

confidence: 99%

Aphanamixis polystachya (Wall.) Parker.

SpringerReference

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Many plants possess antioxidant ingredients that provided efficacy by additive or synergistic activities. Present article highlights an antioxidant activity of a red listed medicinal plant Aphanamixis polystachya bark which has a strong astringent power. It is used for the treatment of rheumatism, tumours, liver and spleen diseases. Antioxidant activity of the crude extracts of A. polystachya (bark) were assessed using DPPH and FRAP assays. The alcohol, aqueous methanol and petroleum ether extracts exhibited potent antioxidant activity compared to known antioxidants. Due to its natural origin and potent free-radical scavenging ability A. Polystachya could be used as a potential preventive action taken to improve free radical-mediated diseases.

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The genus Amoora: A phytochemical and pharmacological review

Wang

et al. 2019

Fitoterapia

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HEPATOPROTECTIVEEFFECT OFAMOORA ROHITUKA

Cited by 5 publications

References 17 publications

Evaluation of Cytotoxic and Anthelmintic Activities of Bark Extract of Aphanamixis Polystachya (Wall.)

Evaluation of Cytotoxic and Anthelmintic Activities of Bark Extract of Aphanamixis Polystachya (Wall.)

Aphanamixis polystachya (Wall.) Parker.

The genus Amoora: A phytochemical and pharmacological review

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