Antihepatotoxic and Antimicrobial Activities of Harungana madagascariensis Leaf Extracts

Antifungal and antibacterial activities of different extracts ofHarungana madagascariensisstem bark

“…Our antibacterial data compared favorably with earlier reports on the leaves of H. madagascariensis showing greater MIC values (Madubunyi et al, 1995;Kamanzi Atindehou et al, 2002;Okoli et al, 2002;Moulari et al, 2006a).Quantification of total activity of plant materials in various therapeutic models have been established, particularly in antioxidant activity of many plants extracts (Miller et al, 1995). Apart from MIC, the total antimicrobial activity (TA) of the extracts can be applied as an index (measurement) of potency among various extracts examined and their time of incubation with microorganisms.…”

“…Kouam et al (2007) have isolated a prenylated 1, 4-anthraquinone from the hexane extract of the stem-bark of H. madagascariensis and have shown it to possess G-glucosidase inhibition and antioxidant activities. Most of the investigations on the pharmacological efficacies of H. madagascariensis are based on the leaves (Madubunyi et al, 1995;Kamanzi Atindehou et al, 2002;Okoli et al, 2002;Moulari et al, 2006aMoulari et al, , 2006bKouam et al, 2007).…”

Antimicrobial Effects Of Three Tropical Plant Extracts On <I>Staphylococcus aureus, Escherichia coli and Candida albicans</I>

“…This is similar to Al-Magboul et al's (1997) research but contrary to Ashebir and Ashenafi (2007) observation of the plants' ability to inhibit E. coli. G. kola has a good antimicrobial properties (Ezeifeka et al, 2004;Madubunyi et al, 1995;Iwu, 1993). The ethanol extract of G. Kola had a good bactericidal properties on S. aureus (26mm zone of inhibition) and on E. coli (20mm zone of inhibition) with no inhibition on C. albicans (Table 2).…”

Anti-protozoan activities of Harungana madagascariensis stem bark extract on trichomonads and malaria

“…a Significantly different from control at p < 0.05. b Significantly different from PYR at p < 0.05. gus and protozoa) in traditional medical practice. The wide reports of Harungana madagascariensis plant parts that are used in various infectious disorders points to the fact that the plant constituents could be potential anti-infective candidates for the treatment of viral, bacteria, fungi, and protozoa (Madubunyi et al, 1995;Okoli et al, 2002;Kamanzi Atindehou et al, 2004;Moulari et al, 2006a,b;Kouam et al, 2007). Our experiments demonstrate that phyto-chemical constituents present in the stem bark extract of Harungana madagascariensis used in traditional medicine to treat infectious diseases, exhibited anti-protozoan activity against Trichomonas gallinae in vitro and Plasmodium parasites both in vivo and in vitro.…”

“…Lukwa et al (2001) made an ethnobotanical survey on some herbal remedies used by traditional healers in Mola, Kariba district of Zimbabwe for the treatment and prevention of malaria, Harungana madagascariensis is one of the plants used for the treatment of malaria. Earlier studies of Harungana madagascariensis were based on the leaves, (Madubunyi et al, 1995;Kamanzi Atindehou et al, 2004;Okoli et al, 2002;Moulari et al, 2006a,b;Kouam et al, 2007). Nwodo (1989) and Kouam et al (2006a,b) have, however, examined the effect of crude extracts and isolated compounds from a hexane extract of the stem bark of Harungana madagascariensis, for their analgesic, anti-inflammatory, alpha-glucosidase inhibition and anti-oxidant activities respectively.…”