Antihistamines for Postacute Sequelae of SARS-CoV-2 Infection

Pinto, Melissa D.; Lambert, Natalie; Downs, Charles A.; Abrahim, Heather L.; Hughes, Thomas D; Rahmani, Amir M.; Burton, Candace W.; Chakraborty, Rana

doi:10.1016/j.nurpra.2021.12.016

Cited by 28 publications

(20 citation statements)

References 20 publications

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“…It is suggested that immune disturbance from SARS-CoV-2 infection may lead to aberrant mast cell activation and further initiate cascades of inflammatory responses contributing to allergic flare-up [54,55]. Histamine antagonists have been used to relieve long COVID associated symptoms [55,56]. However, the interaction of antihistamines with viral-altered ACE2 pathways remains to be elucidated.…”

Section: Mast Cell Activation Syndrome (Mcas) and Anti-histamine Trea...mentioning

confidence: 99%

Long COVID and its Management

Koc¹,

Xiao²,

Liu³

et al. 2022

Int. J. Biol. Sci.

165

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The pandemic of COVID-19 is the biggest public health crisis in 21 st Century. Besides the acute symptoms after infection, patients and society are also being challenged by the long-term health complications associated with COVID-19, commonly known as long COVID. While health professionals work hard to find proper treatments, large amount of knowledge has been accumulated in recent years. In order to deal with long COVID efficiently, it is important for people to keep up with current progresses and take proactive actions on long COVID. For this purpose, this review will first introduce the general background of long COVID, and then discuss its risk factors, diagnostic indicators and management strategies. This review will serve as a useful resource for people to understand and prepare for long COVID that will be with us in the foreseeable future.

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Section: Mast Cell Activation Syndrome (Mcas) and Anti-histamine Trea...mentioning

confidence: 99%

Long COVID and its Management

Koc¹,

Xiao²,

Liu³

et al. 2022

Int. J. Biol. Sci.

165

View full text Add to dashboard Cite

show abstract

“…For instance, according to Crook et al [ 52 ], antihistamines are considered potential DR candidates. Significant improvements in long-term symptoms have been reported in case reports [ 53 ] and observational studies [ 54 ]. This seems to be backed by discussions from long-haulers: antihistamines are the most frequently discussed substances and are important (measured by degree centrality) to the cluster of anti-inflammatory drugs.…”

Section: Discussionmentioning

confidence: 99%

Social Media Mining of Long-COVID Self-Medication Reported by Reddit Users: Feasibility Study to Support Drug Repurposing

Koss¹,

Bohnet-Joschko²

2022

JMIR Form Res

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Background Since the beginning of the COVID-19 pandemic, over 480 million people have been infected and more than 6 million people have died from COVID-19 worldwide. In some patients with acute COVID-19, symptoms manifest over a longer period, which is also called “long-COVID.” Unmet medical needs related to long-COVID are high, since there are no treatments approved. Patients experiment with various medications and supplements hoping to alleviate their suffering. They often share their experiences on social media. Objective The aim of this study was to explore the feasibility of social media mining methods to extract important compounds from the perspective of patients. The goal is to provide an overview of different medication strategies and important agents mentioned in Reddit users’ self-reports to support hypothesis generation for drug repurposing, by incorporating patients’ experiences. Methods We used named-entity recognition to extract substances representing medications or supplements used to treat long-COVID from almost 70,000 posts on the “/r/covidlonghaulers” subreddit. We analyzed substances by frequency, co-occurrences, and network analysis to identify important substances and substance clusters. Results The named-entity recognition algorithm achieved an F1 score of 0.67. A total of 28,447 substance entities and 5789 word co-occurrence pairs were extracted. “Histamine antagonists,” “famotidine,” “magnesium,” “vitamins,” and “steroids” were the most frequently mentioned substances. Network analysis revealed three clusters of substances, indicating certain medication patterns. Conclusions This feasibility study indicates that network analysis can be used to characterize the medication strategies discussed in social media. Comparison with existing literature shows that this approach identifies substances that are promising candidates for drug repurposing, such as antihistamines, steroids, or antidepressants. In the context of a pandemic, the proposed method could be used to support drug repurposing hypothesis development by prioritizing substances that are important to users.

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“…Particularly in the care of PASC patients, it is thus critical that nurses establish a sense of safety with and for patients as the novelty of this condition brings with it uncertainty which can in turn provoke fear and frustration (Lancet, 2021 ). PASC patients report feeling misunderstood, having symptoms dismissed as self‐injury or anxiety and experiencing fear or mistrust of providers as a result (Callard & Perego, 2021 ; Paredes et al, 2021 ; Pinto et al, 2022 ).…”

Section: Conceptual Model Of Trauma‐informed Care For Patients With ...mentioning

confidence: 99%

A novel conceptual model of trauma‐informed care for patients with post‐acute sequelae of SARS‐CoV‐2 illness (PASC)

Burton

Downs

Hughes

et al. 2022

Journal of Advanced Nursing

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Aim This paper proposes a novel, trauma‐informed, conceptual model of care for P ost‐ A cute S equelae of C OVID‐19 illness (PASC). Design This paper describes essential elements, linkages and dimensions of the model that affect PASC patient experiences and the potential impact of trauma‐informed care on outcomes. Data sources PASC is a consequence of the global pandemic, and a new disease of which little is known. Our model was derived from the limited available studies, expert clinical experience specific to PASC survivors and publicly available social media narratives authored by PASC survivors. Implications for nursing The model provides a critical and novel framework for the understanding and care of persons affected by PASC. This model is aimed at the provision of nursing care, with the intention of reducing the traumatic impacts of the uncertain course of this disease, a lack of defined treatment options and difficulties in seeking care. The use of a trauma‐informed care approach to PASC patients can enhance nurses' ability to remediate and ameliorate both the traumatic burden of and the symptoms and experience of the illness. Conclusion Applying a trauma‐informed perspective to care of PASC patients can help to reduce the overall burden of this complex condition. Owing to the fundamentally holistic perspective of the nursing profession, nurses are best positioned to implement care that addresses multiple facets of the PASC experience. Impact The proposed model specifically addresses the myriad ways in which PASC may affect physical as well as mental and psychosocial dimensions of health. The model particularly seeks to suggest means of supporting patients who have already experienced a life‐threatening illness and are now coping with its long‐term impact. Since the scope of this impact is not yet defined, trauma‐informed care for PASC patients is likely to reduce the overall health and systems burdens of this complex condition.

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Antihistamines for Postacute Sequelae of SARS-CoV-2 Infection

Cited by 28 publications

References 20 publications

Long COVID and its Management

Long COVID and its Management

Social Media Mining of Long-COVID Self-Medication Reported by Reddit Users: Feasibility Study to Support Drug Repurposing

A novel conceptual model of trauma‐informed care for patients with post‐acute sequelae of SARS‐CoV‐2 illness (PASC)

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