High-energy physics is primarily concerned with uncovering the laws and principles that govern nature at the fundamental level. Research in this field usually relies on probing the boundaries of established physics, an undertaking typically associated with extreme energy and distance scales. It is therefore unsurprising that particle physics has traditionally been dominated by large-scale experimental methods often involving high energies, such as colliders and storage rings, cosmological and astrophysical observations, large-volume detector systems, etc. The corresponding measurements are ideally suited for the discovery of new particles and interactions.However, high-sensitivity measurements in smaller experiments, often performed at lower energies, are presently experiencing a surge in importance for particle physics for at least two reasons. First, they exploit synergies to adjacent areas of physics with recent advances in experimental techniques and technology. Together with intensified phenomenological explorations, these advances have led to the realization that challenges associated with weak couplings or the expected suppression factors for new physics can be overcome with such methods while maintaining a large degree of experimental control. Second, many of these measurements broaden the range of particle-physics phenomena and observables relative to the above set of more conventional methodologies. Combining such measurements with the conventional efforts above therefore casts both a wider and tighter net for possible effects originating from physics beyond the Standard Model (BSM).The present work argues that this assessment points at a growing impact of such methods and measurements on high-energy physics, and it therefore warrants direct support as particle-physics research. More specifically, we discuss a sample of ongoing and future efforts in this context involving cold neutrons, a range of AMO-based studies, first-and higher-generation antimatter, and microscopic mechanical experiments including gravitationally entangled masses and optically levitated nanospheres. These efforts are poised to yield crucial insights into proposed BSM physics as diverse as novel short-range interactions, the small-scale structure of spacetime and in particular the fate of Lorentz, translation, CPT, CP, T, and P symmetries, the gravitational interaction of antimatter, certain quantum aspects of gravity, millicharged particles, gravitationalwave measurements, and dark matter. These synergies and their prospective physics output foreshadow a promising future for such types of experimental and theoretical activities. Leveraging the recent rapid progress and bright outlook associated with such studies for high-energy physics, could yield high returns, but requires substantial and sustained efforts by funding agencies.