Antihyperglycaemic effect of Mangifera indica in rat

Abstract

The leaves of Mangifera indica are used as an antidiabetic agent in Nigerian folk medicine. To determine whether or not there is a scientific basis for this use, the effect of the aqueous extract of the leaves on blood glucose level was assessed in normoglycaemic, glucose - induced hyperglycaemic and streptozotocin (STZ)-induced diabetic rats. The aqueous extract given orally (1 g/kg) did not alter the blood glucose levels in either normoglycaemic or STZ-induced diabetic rats. In glucose - induced hyperglycaemia, however, antidiabetic activity was seen when the extract and glucose were administered simultaneously and also when the extract was given to the rats 60 min before the glucose. The hypoglycaemic effect of the aqueous extract was compared with that of an oral dose of chlorpropamide (200 mg/kg) under the same conditions. The results of this study indicate that the aqueous extract of the leaves of Mangifera indica possess hypoglycaemic activity. This action may be due to an intestinal reduction of the absorption of glucose. However, other different mechanisms of action cannot be excluded.

Multifaceted Healthy Benefits of <em>Mangifera Indica</em> L. (Mango): The Inestimable Value of an Orchard Recently Rooted in Sicilian Rural Areas

“…Activation of AGE-RAGE axis is associated with diabetic compliances, as cardiomyopathy and nephropathy. Pulp and leaf extracts of mango produced a significant hypoglycemic effect in streptozotocin (STZ)-induced diabetic rats [25][26][27]. Furthermore, Gondi et al [28] showed that also mango peel extracts have the ability to ameliorate diabetes.…”

Effect of Moringa oleifera leaf extract on serum lipids and glycaemic control in alloxan induced diabetic albino rats

“…However, significant reduction in fasting blood glucose in Moringa oleifera treated rats may suggest hypoglycaemic effect of this leave extract. This finding is similar to the reports of Aderibigbe et al 13 .…”

Rediscovering Medicinal Plants' Potential with OMICS: Microsatellite Survey in Expressed Sequence Tags of Eleven Traditional Plants with Potent Antidiabetic Properties

“…An extensive literature survey revealed 11 plants having proven antidiabetic properties that are largely distributed across the geographical niche of NE India. The plants include: Ananas comosus (pineapple), Carica papaya (papaya), Catharanthus roseus (noyontara), Citrus aurantium (bitter orange), Cynodon dactylon (bermuda grass), Dioscorea alata (ratalu), Jatropha curcas (barbados nut), Mangifera indica (mango), Morus indica (mulberry), Nelumbo nucifera (lotus), and Tinospora cordifolia (guduchi) (Aderibigbe et al, 1999;Xie et al, 2005;Huralikuppi et al, 2006;Jarald et al, 2008;Sharma et al, 2008;Mishra et al, 2010;Rasineni et al, 2010;Kumar et al, 2010;Maithili et al, 2011;Juarez-Rojop et al, 2012;Sangeetha et al, 2013). Although much progress have been made in recent years in many medicinal plants, the study of genetic potential and improvement through molecular breeding has not been attempted to date for the above mentioned plants.…”