Antihyperglycaemic effect of Mangifera indica in rat

Effect of mangiferin on hyperglycemia and atherogenicity in streptozotocin diabetic rats

“…significantly improved oral glucose tolerance in glucose-loaded normal rats indicating its potent antihyperglycemic activity. This result is in accordance with the previous results conducted with the aqueous extract of Mangifera indica leaves further suggesting that the active principle, mangiferin might be responsible for the glucose lowering action on oral glucose tolerance test (Aderibigbe et al, 1999(Aderibigbe et al, , 2001. These evidences tempt us to speculate that apart from the aforementioned probable insulin independent extrapancreatic actions, the other possible pancreatic mechanism, i.e.…”

“…Mangiferin has been reported to possess antioxidant (Sanchez et al, 2000), antitumor (Guha et al, 1996), antiviral (Zheng and Lu, 1990;Zhu et al, 1993;Yoosook et al, 2000) and immunomodulatory activities (Guha et al, 1996;Leiro et al, 2004). The aqueous extract of Mangifera indica leaves has been reported to possess hypoglycemic activity in glucose-induced hyperglycemic rats as well as in mice (Aderibigbe et al, 1999(Aderibigbe et al, , 2001. Furthermore, the active principle, mangiferin has recently been shown to have antidiabetic activity in KK/Ay mice, a genetic model of non-insulin-dependent diabetes mellitus (NIDDM) with hyperinsulinemia (Ichiki et al, 1998;Miura et al, 2001a,b).…”

Leads from Indian medicinal plants with hypoglycemic potentials

“…), given along with as well as 60 min before glucose administration in streptozotocin-induced diabetic rats (Aderibigbe et al, 1999) Possibly acts through intestinal reduction of the absorption of glucose (Aderibigbe et al, 1999) as well as pancreatic and extrapancreatic mechanisms (Muruganandan et al, 2005) Hypoglycemic activity of Mangiferin (10 and 20 mg/kg, i.p. once daily for 28 days) in STZ induced diabetic rats and improvement in oral glucose tolerance in glucose-loaded normal rats upon chronic administration (10 and 20 mg/kg, i.p.)…”

“…The aqueous leaf-extract (1 g/kg) failed to exert any hypoglycemic activity in normoglycemic as well as streptozotocin-induced diabetic rats upon oral administration (Aderibigbe et al, 1999). Antihyperglycemic activity of the leaf extract at the same dose level was investigated by the same author in different experimental condition (Table 1) along with its antioxidant activity (Martinez et al, 2000).…”

Antihyperglycemic and Antioxidant Activities of Medicinal PlantStereospermum suaveolensin Streptozotocin-induced Diabetic Rats

“…Overnight-fasted rats were divided into four groups of six animals each (Aderibigbe, Emudianughe, & Lawal, 1999). Group I served as a control and received only a single oral dose of normal saline (5 ml/kg).…”