Antihyperglycaemic potential of rosmarinic acid attenuates glycoprotein moiety in high-fat diet and streptozotocin-induced diabetic rats

Abstract

Rosmarinic acid is a polyphenolic phytoconstituent isolated from the leaves of Plectranthus amboinicus and its structure was established by analysis of its 1 H, 13 C and HRMS. The effect of rosmarinic acid was evaluated by deranged plasma and tissues glycoprotein components in diabetic rats. Rosmarinic acid was administered to diabetic rats for 30 days significantly declined the levels of blood glucose and glycosylated haemoglobin with elevation of plasma insulin and haemoglobin levels. Rosmarinic acid administration improved the glycogen content in liver and muscle tissue by reinstating the altered glycogen metabolic enzymes such as glycogen synthase and glycogen phosphorylase. Further, the altered levels of plasma and tissue glycoprotein components were restored to near normal upon treatment with rosmarinic acid. In addition, rosmarinic acid treatment prevented body weight loss and excessive intake of food and water. The effect produced by the rosmarinic acid on various parameters was comparable to that of metformin.

A Systematic Review of Orthosiphon stamineus Benth. in the Treatment of Diabetes and Its Complications

“…For diabetic complications, vanillic acid ameliorated diabetic liver dysfunction by lowering the levels of aspartate aminotransferase (AST) and alanine aminotransferase (ALT). It also decreases the levels of urea, uric acid, and creatinine in kidney [106]. Protocatechuic acid and rosmarinic acid reduce histological changes in kidney tissues in diabetic nephropathy animals [103,107].…”

“…Methyl caffeate and rosmarinic acid could protect islet β-cells [96]. Ferulic acid and rosmarinic acid also have anti-glycation effects to decrease the formation of AGEs [95,106]. For diabetic complications, vanillic acid ameliorated diabetic liver dysfunction by lowering the levels of aspartate aminotransferase (AST) and alanine aminotransferase (ALT).…”

Geraniol ameliorates the progression of high fat‐diet/streptozotocin‐induced type 2 diabetes mellitus in rats via regulation of caspase‐3, Bcl‐2, and Bax expression

“…Group I (NC): rats received a standard diet (3% fat, 54% carbohydrate, 26% protein, 17% vitamins, and minerals with a total energy of 14.43 kJ/g) and water, while 28 rats were fed a high‐fat diet (HFD) with a total energy of 25.07 kJ/g containing 60% fat, 20% carbohydrate, and 20% protein for consecutive 4 weeks. After fasting overnight, HFD‐fed rats obtained a single intraperitoneal streptozotocin (STZ), 35 mg/kg body weight, freshly prepared in citrate buffer (0.05 M, pH 4.5) (Ramalingam et al, 2020). The level of the blood glucose was tracked 3 days later using a glucose meter (Accu‐Chek® Aviva, Roche Diagnostics, India).…”

The efficacy ofOriganum majoranananocubosomal systems in ameliorating submandibular salivary gland alterations in streptozotocin-induced diabetic rats

“…RA was also reported to induce glucose-lowering effect in STZ-induced diabetic rats by stimulating the surviving β-cells of the islets of Langerhans to secrete more insulin. It also reduced insulin resistance measures, indicating that the antioxidant capacity of RA helps to restore insulin sensitivity (Ramalingam et al., 2020 ).…”