Antihyperglycemic Activity and Chemical Constituents of <i>Eysenhardtia platycarpa</i>

Narváez-Mastache, José M.; Garduño-Ramı́rez, Marı́a Luisa; Álvarez, Laura; Delgado, Guillermo

doi:10.1021/np060166z

Cited by 50 publications

(50 citation statements)

References 36 publications

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“…Lupeol has been reported to exhibit anti-diabetic activity in in vitro and in vivo models (Ali et al, 2006;Narvaez-Mastache et al, 2006;OrtizAndrade et al, 2007;Na et al, 2009). Several studies showed that lupeol exhibits antihyperglycemic activity and its administration lowers the risk of development of diabetes in animal models (Ali et al, 2006;Narvaez-Mastache et al, 2006Ortiz-Andrade et al, 2007Na et al, 2009).…”

Section: Lupeol As Anti-diabetic Agentmentioning

confidence: 99%

Beneficial health effects of lupeol triterpene: A review of preclinical studies

2011

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Section: Lupeol As Anti-diabetic Agentmentioning

confidence: 99%

Beneficial health effects of lupeol triterpene: A review of preclinical studies

2011

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“…oral) in STZ-induced diabetic rats. 14) Likewise, Shaiq et al 36) demonstrated that oleanolic acid and some of its derivatives inhibit a-glucosidase; therefore, the hypoglycemic effect of 6 and 1 could be due to this mechanism.…”

Section: Discussionmentioning

confidence: 99%

“…12) Previous studies on Eysenhardtia species have highlighted the hypoglycemic activity of E. polystachya 13) and the antihyperglycemic activity of E. platycarpa, 14) as well as the isolation of cytotoxic flavonoids 15,16) and 3-O-acetyloleanolic acid [which displayed antihyperglycemic activity in streptozotocin (STZ)-induced diabetic rats 14) ]. As part of our screening of plants for the isolation of substances with antioxidant and antihyperglycemic potential, 14,17) this study was conducted to A) assess the antioxidant effects of extracts from E. platycarpa, E. punctata, and E. subcoriacea, as well as of compounds 1-8, natural constituents isolated from E. platycarpa (Chart 1), in a rat pancreas model and in a 1,1 diphenyl-2-picrylhydrazyl (DPPH) radical scavenger assay; B) synthesize 1, which displayed a protective effect against 2,2-azo-bis(2-amidinopropane)dihydrochloride (AAPH)-induced damage in pancreatic homogenate; and C) evaluate the protective effect of 1 in STZinduced diabetic rats.…”

Section: )mentioning

confidence: 99%

“…As part of our screening of plants for the isolation of substances with antioxidant and antihyperglycemic potential, 14,17) this study was conducted to A) assess the antioxidant effects of extracts from E. platycarpa, E. punctata, and E. subcoriacea, as well as of compounds 1-8, natural constituents isolated from E. platycarpa (Chart 1), in a rat pancreas model and in a 1,1 diphenyl-2-picrylhydrazyl (DPPH) radical scavenger assay; B) synthesize 1, which displayed a protective effect against 2,2-azo-bis(2-amidinopropane)dihydrochloride (AAPH)-induced damage in pancreatic homogenate; and C) evaluate the protective effect of 1 in STZinduced diabetic rats. The antioxidant activities of plant extracts from Eysenhardtia platycarpa, E. punctata, and E. subcoriacea (Fabaceae) species, used in Mexican traditional medicine for the treatment of diabetes complications, were analyzed in a rat pancreas homogenate model.…”

Section: )mentioning

confidence: 99%

“…Plants were selected following the reported information and focusing on Fabaceae species used in Mexican traditional medicine, [11][12][13][14] particularly those belonging to Eysenhardtia. E. platycarpa PENNELL & SAFFORD ex PENNELL (1325), E. punctata PENNELL (88577) and E. subcoriacea PENNELL (11322) were collected in Tetipac, Guerrero; Huautla, Morelos; and Ixmiquilpan, Hidalgo, respectively.…”

Section: Plant Materialsmentioning

confidence: 99%

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Antioxidant Evaluation of Eysenhardtia Species (Fabaceae): Relay Synthesis of 3-O-Acetyl-11.ALPHA.,12.ALPHA.-epoxy-oleanan-28,13.BETA.-olide Isolated from E. platycarpa and Its Protective Effect in Experimental Diabetes

Narváez-Mastache

Soto

Delgado

2007

Biological & Pharmaceutical Bulletin

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Recently, attention has been focused on the relationship between reactive oxygen species (ROS) and several disorders including aging, various inflammatory diseases, carcinogenesis, neurodegenerative diseases, and diabetes. 1) In fact, diabetes is usually accompanied by increased production of ROS 2) and impaired antioxidant defense, 3) indicating a central contribution of ROS to the onset, progression, and pathological consequences of diabetes. There is considerable evidence that chronic hyperglycemia is the proximate cause of retinopathy, kidney failure, neuropathies, and macrovascular diseases in diabetes.1) In addition, it has been demonstrated that b cells are particularly susceptible to oxidative damage. 4)Therefore, as hyperglycemia worsens, b cells steadily deteriorate, secrete less insulin, and participate in a downward spiral of loss of pancreatic functions.The current treatments of diabetes are based on a combination of diet, oral hypoglycemic agents, and insulin intake, which focus on decreasing the blood glucose level.5) Although some oral hypoglycemic agents have been associated with enhancement of the antioxidant system, 6) they do not prevent the gradual loss of b-cell functions, which is known to account for gradual deterioration of glucose homeostasis. Therefore, the treatment of micro-and macrovascular complications has required the combined use with several herbal preparations and dietary supplements.7) Many natural products 8,9) and medicinal plants 7) have been shown to significantly reduce oxidative stress and increase the antioxidant endogenous system, which represent a important property of plant medicines used for the treatment of several diseases including diabetes. In this sense, approximately 306 species from 235 genera and 93 families have been used empirically as hypoglycemic agents in Mexican traditional medicine. 10)Eysenhardtia platycarpa, E. subcoriacea, and E. punctata, known indiscriminately as 'palo dulce' (sweet wood), are traditionally used for the treatment of bladder infections and kidney diseases related to diabetes. 11) Eysenhardtia is a small genus that comprises 14 species indigenous to North and Central Mexico.12) Previous studies on Eysenhardtia species have highlighted the hypoglycemic activity of E. polystachya 13) and the antihyperglycemic activity of E. platycarpa, 14) as well as the isolation of cytotoxic flavonoids 15,16) and 3-O-acetyloleanolic acid [which displayed antihyperglycemic activity in streptozotocin (STZ)-induced diabetic rats 14) ]. As part of our screening of plants for the isolation of substances with antioxidant and antihyperglycemic potential, 14,17) this study was conducted to A) assess the antioxidant effects of extracts from E. platycarpa, E. punctata, and E. subcoriacea, as well as of compounds 1-8, natural constituents isolated from E. platycarpa (Chart 1), in a rat pancreas model and in a 1,1 diphenyl-2-picrylhydrazyl (DPPH) radical scavenger assay; B) synthesize 1, which displayed a protective effect against 2,2-azo-bis(2-amidinopropane...

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Lupeol and Its Role in Chronic Diseases

Tsai

Lin

Wu³

2016

Advances in Experimental Medicine and Biology

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Lupeol belongs to pentacyclic lupane-type triterpenes and exhibits in edible vegetables, fruits and many plants. Many researches indicated that lupeol possesses many beneficial pharmacological activities including antioxidant, anti-inflammatory, anti-hyperglycemic, anti-dyslipidemic and anti-mutagenic effects. From various disease-targeted animal models, these reports indicated that lupeol has anti-diabetic, anti-asthma, anti-arthritic, cardioprotective, hepatoprotective, nephroprotective, neuroprotective and anticancer efficiency under various routes of administration such as topical, oral, subcutaneous, intraperitoneal and intravenous. It is worth mentioning that clinical trials of lupeol were performed to treat canine oral malignant melanoma and human moderate skin acne in Japan and Korea. The detailed mechanism of anti-inflammatory, anti-diabetic, hepatoprotective and anticancer activities was further reviewed from published papers. These evidence indicate that lupeol is a multi-target agent to exert diverse pharmacological potency with many potential targeting proteins such as α-glucosidase, α-amylase, protein tyrosine phosphatase 1B (PTP 1B) and TCA cycle enzymes and targeting pathway such as IL-1 receptor-associated kinase-mediated toll-like receptor 4 (IRAK-TLR4), Bcl-2 family, nuclear factor kappa B (NF-kB), phosphatidylinositol-3-kinase (PI3-K)/Akt and Wnt/β-catenin signaling pathways. This review also provides suggestion that lupeol might be a valuable and potential lead compound to develop as anti-inflammatory, anti-diabetic, hepatoprotective and anticancer drugs.

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Antihyperglycemic Activity and Chemical Constituents of Eysenhardtia platycarpa

Cited by 50 publications

References 36 publications

Beneficial health effects of lupeol triterpene: A review of preclinical studies

Beneficial health effects of lupeol triterpene: A review of preclinical studies

Antioxidant Evaluation of Eysenhardtia Species (Fabaceae): Relay Synthesis of 3-O-Acetyl-11.ALPHA.,12.ALPHA.-epoxy-oleanan-28,13.BETA.-olide Isolated from E. platycarpa and Its Protective Effect in Experimental Diabetes

Lupeol and Its Role in Chronic Diseases

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