Antihyperglycemic activity of various fractions of &lt;i&gt; Cassia auriculata&lt;/i&gt; linn. in alloxan diabetic rats

Surana, SJ; Gokhale, SB; Jadhav, RB; Sawant, Ramesh L.; Wadekar, Jyoti B.

doi:10.4103/0250-474x.41461

Cited by 32 publications

(5 citation statements)

References 7 publications

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“…Alloxan-induced beta cell cytotoxicity is a well-established animal model to study antidiabetic activity (Surana et al, 2008[ 13 ]). In this study, we observed a decrease in the blood glucose level in both normal and alloxan diabetic rats when treated with the title compounds.…”

Section: Resultsmentioning

confidence: 99%

Targeting PPAR-γ to design and synthesize antidiabetic thiazolidines

Sawant

Wadekar

Kharat

et al. 2018

EXCLI Journal; 17:Doc598; ISSN 1611-2156

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Section: Resultsmentioning

confidence: 99%

Targeting PPAR-γ to design and synthesize antidiabetic thiazolidines

Sawant

Wadekar

Kharat

et al. 2018

EXCLI Journal; 17:Doc598; ISSN 1611-2156

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“…Hakkim, Girija, Kumar, and Jalaludeen (2007) exposed the antidiabetic potential of aqueous and ethanol extract of Cassia auriculata flowers in alloxan-induced diabetic rats which indicated noteworthy reduction in the blood glucose level and an exceptional increase in plasma insulin level after 48 hours at a dose of 0.25 and 0.5g/kg of body of weight, for 30 days. Surana, Gokhale, Jadhav, Sawant, and Wadekar (2008) portrayed the strong antidiabetic part from Cassia auriculata flowers at a dose of 0.20 g/kg body weight in alloxan-instigated diabetes in rats, when its methanolic extract which specified the presence of phenolic compounds, carbohydrates, tannins, steroids and amino acids showed a huge reduction in blood glucose levels and was additionally seen as viable in reestablishing the blood lipids and proteins to typical level and its action was discovered practically identical with the standard medication phenformin. Shanmugasundaram, Devi, Soris, Maruthupandian, and Mohan (2011) demonstrated that the ethanol extract of Senna auriculata for its antidiabetic impact in diabetes instigated wistar albino rats by administration of alloxan monohydrate (150mg/Kg, i.p) evoked a huge decrease in blood glucose.…”

Section: Discussionmentioning

confidence: 99%

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2020

The International Journal of Biotechnology

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Contrary to the synthetic drugs, phytochemical constituents of plant origin possess an enormous therapeutic potential as antibacterial and antidiabetic agents. The phytochemicals of Senna auriculata floral extracts and avaram tea were screened and tested for antibacterial and antidiabetic properties respectively. Antibacterial activity was determined by disc diffusion method at 0.25, 0.50 and 1.00% concentrations against Escherichia coli, Klebsiella pneumonia, Pseudomonas aeruginosa and Staphylococcus aureus. Overall results indicated maximum antibacterial activity at the lowest concentration (0.25%) by the petroleum ether, acetone, ethyl acetate and methanol extracts against Escherichia coli, Staphylococcus aureus; Escherichia coli and Staphylococcus aureus and their respective zone of inhibition values were 32, 28, 22 and 15mm; at the highest concentration (1.00%) it was exhibited against Staphylococcus aureus for all extracts except for methanol against Klebsiella pneumonia and the values were 36, 34, 30 and 19mm respectively. Experiments were carried with male albino wistar mice treated with streptozotocin to study the antidiabetic property for a period of 21 days. The body weight of mice after treatment decreased on Day 7 when compared to Day 3 and then increased on Day 14 and 21. The blood glucose level decreased right from Day 3 to 21. Further, it is suggested that the molecular basis for the modes of action of plant-based antibiotics and antidiabetics be ascertained and determined. Contribution/Originality: This study documents and highlights Avaram tea as a potential antidiabetic agent as the flowers of Senna auriculata is prescribed for diabetes in traditional practices in Siddha, besides its phytochemical compounds with proven antibacterial action. 1. INTRODUCTION On one hand, infectious diseases are the leading cause of death throughout the world, and drug resistance to human pathogenic bacteria has been commonly reported from all over the world (Cohen, 1992; Piddock & Wise, 1989). Antibiotic resistance has become a global concern. Increasing development of drug resistance in human pathogens as well as the appearance of side effect of synthetic drugs need to develop new antimicrobial drugs from

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“…Glibenclamide (GLB) 600 μg/kg was administered to group IV as a reference standard drug[ 8 ] suspended in vehicle. Suspensions were prepared using 0.3% w/v sodium carboxy methylcellulose in distilled water[ 9 ]. The baseline fasting blood glucose was determined before oral administration of respective treatment.…”

Section: Methodsmentioning

confidence: 99%

Antihyperglycemic and antihyperlipidemic activity of Plectranthus amboinicus on normal and alloxan-induced diabetic rats

et al. 2011

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The present study was undertaken to investigate the antihyperglycemic and antihyperlipidemic effects of ethanol extract of Plectranthus amboinicus in normal and alloxan-induced diabetic rats. Diabetes was induced in Wistar rats by single intraperitoneal administration of alloxan monohydrate (150 mg/kg). Normal as well as diabetic rats were divided into groups (n=6) receiving different treatments. Graded doses (200 mg/kg and 400 mg/kg) of ethanol extract of Plectranthus amboinicus were studied in both normal and alloxan-induced diabetic rats for a period of 15 days. Glibenclamide (600 μg/kg) was used as a reference drug. Oral administration with graded doses of ethanol extract of Plectranthus amboinicus exhibited hypoglycemic effect in normal rats and significantly reduced the peak glucose levels after 120 min of glucose loading. In alloxan-induced diabetic rats, the daily oral treatment with ethanol extract of Plectranthus amboinicus showed a significant reduction in blood glucose. Besides, administration of ethanol extract of Plectranthus amboinicus for 15 days significantly decreased serum contents of total cholesterol, triglycerides whereas HDL-cholesterol, total proteins and calcium were effectively increased. Furthermore, effect of ethanol extract of Plectranthus amboinicus showed profound elevation of serum amylase and reduction of serum lipase. Histology examination showed ethanol extract of Plectranthus amboinicus exhibited almost normalization of damaged pancreatic architecture in rats with diabetes mellitus. Studies clearly demonstrated that ethanol extract of Plectranthus amboinicus leaves possesses hypoglycemic and antihyperlipidemic effects mediated through the restoration of the functions of pancreatic tissues and insulinotropic effect.

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Antihyperglycemic activity of various fractions of <i> Cassia auriculata</i> linn. in alloxan diabetic rats

Cited by 32 publications

References 7 publications

Targeting PPAR-γ to design and synthesize antidiabetic thiazolidines

Targeting PPAR-γ to design and synthesize antidiabetic thiazolidines

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Antihyperglycemic and antihyperlipidemic activity of Plectranthus amboinicus on normal and alloxan-induced diabetic rats

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