Antihyperglycemic and antihyperlipidemic activity of Plectranthus amboinicus on normal and alloxan-induced diabetic rats

Abstract

The present study was undertaken to investigate the antihyperglycemic and antihyperlipidemic effects of ethanol extract of Plectranthus amboinicus in normal and alloxan-induced diabetic rats. Diabetes was induced in Wistar rats by single intraperitoneal administration of alloxan monohydrate (150 mg/kg). Normal as well as diabetic rats were divided into groups (n=6) receiving different treatments. Graded doses (200 mg/kg and 400 mg/kg) of ethanol extract of Plectranthus amboinicus were studied in both normal and alloxan-induced diabetic rats for a period of 15 days. Glibenclamide (600 μg/kg) was used as a reference drug. Oral administration with graded doses of ethanol extract of Plectranthus amboinicus exhibited hypoglycemic effect in normal rats and significantly reduced the peak glucose levels after 120 min of glucose loading. In alloxan-induced diabetic rats, the daily oral treatment with ethanol extract of Plectranthus amboinicus showed a significant reduction in blood glucose. Besides, administration of ethanol extract of Plectranthus amboinicus for 15 days significantly decreased serum contents of total cholesterol, triglycerides whereas HDL-cholesterol, total proteins and calcium were effectively increased. Furthermore, effect of ethanol extract of Plectranthus amboinicus showed profound elevation of serum amylase and reduction of serum lipase. Histology examination showed ethanol extract of Plectranthus amboinicus exhibited almost normalization of damaged pancreatic architecture in rats with diabetes mellitus. Studies clearly demonstrated that ethanol extract of Plectranthus amboinicus leaves possesses hypoglycemic and antihyperlipidemic effects mediated through the restoration of the functions of pancreatic tissues and insulinotropic effect.

Effects of Torbangun Leaves(Coleus amboinicus Lour) Extract on Blood Glucose and Super Oxide Dismutase Activity in Hyperglycemic Rats

“…Sonication step was repeated twice with the addition of 100 ml ethanol in each repetition. Solvent evaporation of the extract was carried out with a rotary evaporator at temperature of 60 o C until semi solid liquid was obtained (Viswanathaswamy et al 2011). The extract obtained was stored at 4 o -8 o C (Uma et al 2011).…”

“…Furthermore, Suryowati (2015) found that torbangun leaves extract at a dose of 620 mg/kg of BW for 14 days had the potential to reduce blood glucose levels and free radicals, increase glucokinase enzymes, and protect the pancreatic β-cells in rats induced by Streptozotocin (STZ). Previously, Viswanathaswamy et al (2011) reported that torbangun leaves extract could improve the function of pancreatic tissue and showed an insulin tropic effects (production, secretion, and insulin activity) in experimental animals.…”

The Effect of Bangunbangun (Plectranthus amboinicus L. Spreng) Supplemented in Feed on the Quality of Broiler Chicken Meat

“…Bangunbangun (Plectranthus amboinicus L. Spreng) was chosen as an ingredient in chicken feed supplementation which contained several components, such us various vitamins and secondary metabolites which were very useful. This Statement also proven by Koti et al (2011) research about the activity of Bangunbangun (Plectranthus amboinicus L. Spreng) as antihyperglycemic and antihyperlipidemic on normal and alloxaninduced diabetic rats.…”

“…From the occurrence of liver weight while the higher doses given, give a conclusion that the supplementation of bangunbangun leaves flour decrease the cholesterol level in the body. This is because bangunbangun contains niacin or nicotinate acid that affect the cholesterol flushing in blood vessel (Koti et al, 2011 andHaryanto et al, 2017). Niasin is a vitamin Bkompleks derivate such as coenzim NAD (nicotin amide-adenin dinukleotida) and NADP (nicotin amide-adenin dinukleotida fosfat) which are have a very important role in oxidatingreduction process.…”

NMR metabolomics revealed metabolites and bioactivity variation in Torbangun leaves Plectranthus amboinicus L. with different origins

“…Many compounds have been identified from P. amboinicus leaves (Brieskorn 1977;Brieskorn and Riedel 1977). The antihyperglycemic (Viswanathaswamy et al 2011), and anti-inflammatory (El-Hawary et al 2012) potential of the plant extracts were reported. Indeed, this pharmacological potential highlights the relevance of the plant in the treatment of increasingly relevant degenerative disease.…”