Antihyperglycemic and antihyperlipidemic activity of ethyl acetate fraction of Rhododendron arboreum Smith flowers in streptozotocin induced diabetic rats and its role in regulating carbohydrate metabolism

Verma, Neeraj; Gupta, Ashish; Sahu, Pratap Kumar; Rao, Ch. V.; Singh, A. P.

doi:10.1016/s2221-1691(12)60212-3

Cited by 23 publications

(17 citation statements)

References 15 publications

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“…The selected ligands were dealt with online tool Molinspiration and calculated their bioactivity score and molecular properties [15]. The presumption with the ligands was calculated using various parameters like MiLogP, TPSA, nAtoms, MW, nON, nOHNH, nViolations, nRotb and volume as in Table-1.…”

Section: Resultsmentioning

confidence: 99%

A Computational Study of Anticancer Activity of Curcumin Derivatives Using in silico Drug Designing and Molecular Docking Tools

Shefrin¹,

Manakadan²,

Saranya³

2018

Asian J. Chem.

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Section: Resultsmentioning

confidence: 99%

A Computational Study of Anticancer Activity of Curcumin Derivatives Using in silico Drug Designing and Molecular Docking Tools

Shefrin¹,

Manakadan²,

Saranya³

2018

Asian J. Chem.

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“…It has been reported that RH has a hepatoprotective effect and that the R. Arboreum species decreases cholesterol and triglycerides (Prakesh et al, 2008;Verma et al, 2011). While it has been found that 50 mg RH significantly decreased glucose and lipid levels in rats with experimental diabetes (Öztasan et al;Verma et al, 2012). Uzun et al (2013) found that RH doesn't have any effect on blood glucose levels in humans.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Rhododendron Honey on Mice Liver Tissue

et al. 2016

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ILTER, G.; SÖYLER, G.; RASGELE, P. G.; KEKEÇOGLU, M & KAMBUR, M. The effect of rhododendron honey on mice liver tissue. Int. J. Morphol., 34(3): 842-847, 2016. SUMMARY: Rhododendron honey, made by bees from rhododendron pollen, contains a toxic substance called grayanotoxin. Depending on the dose, the poisonous honey can result in serious effects such as cardiac arrhythmia, fibrillation, and myocardial infarction. The purpose of this study is to investigate the effects of the poisonous RH of the Black Sea Region on the liver. Male mice were divided into five groups of twelve mice each, two being the control groups (distilled water) and the others being the rhododendron honey (RH) groups (25, 50, and 75 mg/kg) and 0.01 mg/kg grayanotoxin (GTx) groups. Liver tissues were collected 24 and 48 h later. The sections were stained with hematoxylin, eosin and PAS, then the histopathological score was performed. Significant statistical differences were observed between the RH and control groups in terms of congestion, steatosis, sinusoid dilatation, and inflammation. The control group demonstrated a normal liver structure in the light microscopy, while the GTx-applied 24 h group exhibited expansions in the sinusoids and congestion. Higher levels of congestion, steatosis, and inflammatory cells were seen in the GTx-applied 48 h group. In the same group, giant cells consisting of many nuclei were observed in the sinusoids. The results of the 25 mg RH-applied groups were similar in 24 and 48 h, histopathological score levels were increased slightly, congestion and steatosis were prominent in the 48 h group. Dense steatosis was seen in the hepatocytes around the vena centralis in 50 mg/kg RH-applied 48 h group. Congestion, steatosis and an increase in inflammatory cells were observed in the hepatocytes in the 75 mg/kg RH-applied 24-and 48 h groups. PAS (+) stained hepatocytes were decreased in the RH-and GTx-applied groups. The toxic effects of the rhododendron honey were observed in the mice liver tissue with respect to dose and time. KÜKNER, A.; ILTER, G.; SÖYLER, G.; RASGELE, P. G.; KEKEÇOGLU, M & KAMBUR, M. The effect of rhododendron honey on mice liver tissue. Int. J. Morphol., 34(3):842-847, 2016.

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“…In the analysis, it was hypothesized that molecules having a positive biological value (more than 0.00) are supposed to have good biological activity and those having biological score <−0.50 are considered to be biologically inactive while compounds with value in between −0.50 and 0.00 are recognized as a mild to moderate active [61]. All the compounds were docked different onto MGAM receptor (a brush border membrane enzyme responsible for digestion dietary starch to glucose) with assumption that the herbal derivatives possess good MGAM inhibitory activity.…”

Section: Ochieng Et Almentioning

confidence: 99%

Molecular Docking and Pharmacokinetic Prediction of Herbal Derivatives as Maltase-Glucoamylase Inhibitor

Ochieng

Sumaryada

Okun

2017

Asian J Pharm Clin Res

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Objective: To perform molecular docking and pharmacokinetic prediction of momordicoside F2, beta-sitosterol, and cis-N-feruloyltyramine herbal derivatives as maltase-glucoamylase (MGAM) inhibitors for the treatment of diabetes. Methods:The herbal derivatives and standard drug miglitol were docked differently onto MGAM receptor using AutoDock Vina software. In addition, Lipinski's rule, drug-likeness, and absorption, distribution, metabolism, excretion, and toxicity (ADMET) properties were analyzed using Molinspiration, ADMET structure-activity relationship, and prediction of activity spectra for substances online tools.Results: Docking studies reveal that momordicoside F2, beta-sitosterol, and cis-N-feruloyltyramine derivatives have high binding affinity to the MGAM receptor (−7.8, −6.8, and −6.5 Kcal/Mol, respectively) as compared to standard drug miglitol (−5.3 Kcal/Mol). In addition, all the herbal derivatives indicate good bioavailability (topological polar surface area <140 Ȧ and N rot <10) without toxicity or mutagenic effects. Conclusion:The molecular docking and pharmacokinetic information of herbal derivatives obtained in this study can be utilized to develop novel MGAM inhibitors having antidiabetic potential with better pharmacokinetic and pharmacodynamics profile.

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Antihyperglycemic and antihyperlipidemic activity of ethyl acetate fraction of Rhododendron arboreum Smith flowers in streptozotocin induced diabetic rats and its role in regulating carbohydrate metabolism

Cited by 23 publications

References 15 publications

A Computational Study of Anticancer Activity of Curcumin Derivatives Using in silico Drug Designing and Molecular Docking Tools

A Computational Study of Anticancer Activity of Curcumin Derivatives Using in silico Drug Designing and Molecular Docking Tools

The Effect of Rhododendron Honey on Mice Liver Tissue

Molecular Docking and Pharmacokinetic Prediction of Herbal Derivatives as Maltase-Glucoamylase Inhibitor

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