Antihyperglycemic and antihyperlipidemic effects of Ziziphus vulgaris L. onreptozocin-induced diabetic adult male Wistar rats

Abstract

Herbal medicine and medical plants such as Ziziphus vulgaris L. are widely used for the treatment of diseases such as diabetes mellitus. We investigated the effects of water extracts of Ziziphus vulgaris L. fruit on serum glucose, triglycerides, LDL-cholesterol, HDL-cholesterol and activities of aminotransferase enzymes inreptozocin-induced diabetic adult male rats. Continuous supplementation of this water extract by gavage at doses of 0.25, 0.5, 1, 1.5 and 2 g/kg in 0.5 ml distilled water in diabetic rats resulted in a significant decrease of fasting blood glucose and LDL-cholesterol and triglyceride levels after 14 days. The levels of HDL-cholesterol and insulin, and activities of serum aminotransaminase enzymes, alanine aminotransferase and aspartate aminotransferase were not changed significantly in the extract-supplemented group compared to the control group.

Effect of Ziziphus jujube Fruit Infusion on Lipid Profiles, Glycaemic Index and Antioxidant Status in Type 2 Diabetic Patients: A Randomized Controlled Clinical Trial

“…Similar results have also been reported in rats that received hepatotoxic agents (Yossef et al , ). In a study on diabetic rats that were gavaged with extract of ZJF, TG levels decreased but the levels of LDL‐C and HDL‐C were not significantly changed after 14 days (Solati and Soleimani, , ). Water extract of ZJF indicated no significant change in HDL‐C level in diabetic rats (Solati and Soleimani, , ).…”

“…Several studies have shown the effects of this fruit on obesity and hyperlipidaemia (Sabzghabaee et al, 2013), liver disorders (Shen et al, 2009), hypertension (Koffi et al, 2008) and infectious disease. Antidiabetic and hypolipidaemic effects of Ziziphus have been illustrated in streptozocin-induced diabetic rats (Glombitza et al, 1994, Naftali et al, 2009, Solati and Soleimani, 2010a, 2010b, Hemmati et al, 2015. Avizeh et al (2010) demonstrated that administration of Ziziphus spina-christi extract for 10 days is associated with reduction in blood glucose level and increase in serum insulin, in diabetic dogs.…”

Phytochemistry and pharmacologic properties of Ziziphus spina christi (L.) Willd.

“…The genus Ziziphus consists of about 100 species of deciduous or evergreen trees and shrubs throughout the world (Abalaka et al, 2010). Z. spinachristi has been among the key plants of the Iranian traditional medicine since ancient times and is indigenous and naturalized throughout Iran (Solati and Soleimani, 2010). It has been known as "Sedr" in Iran and wildly distributed in East, South, North-East and central parts of *Corresponding author.…”

The protective effects of Ziziphus vulgaris L. fruits on biochemical and histological abnormalities induced by diabetes in rats

“…Selection of this dose was based on previous studies which administered jujube extract at the same dose [14]. STZ in low dose is a β-cell toxin that has been commonly used for rapid and irreversible induction of type I diabetes [15].…”