Abstract:To investigate the antihyperglycemic and antihyperlipidemic effect of Momordica charantia (Karala), the aqueous extract of the Karala fruit was tested on streptozotocin (STZ)-induced diabetic rats. Thirty six albino rats were used in the experiment, 30 diabetic and the remaining six as negative control (T1). Diabetes was induced by administering (injecting) STZ at dose of 55mg/kg body weight. Thirty diabetic animals were randomly divided into five groups such as diabetic control group (T2) without any applicat… Show more
“…Shetty et al [ 25 ] also found a marginal increase in body weight of diabetic rats fed with diet containing bitter gourd. Similar findings by Hossain et al [ 27 ] also strengthen the current results that body weight of diabetic groups treated with bitter gourd was higher than the untreated diabetic group. Fig.…”
Section: Resultssupporting
confidence: 92%
“…Serum creatinine and urea concentration was also remained in normal ranges due to feeding of bitter gourd in diet. The current data is comparable to the earlier investigations of Hossain et al [ 27 ] confirmed a reduction in serum ALP, ALT and AST of rats treated with bitter gourd extract. In another study noted that bitter gourd is helpful in reducing the amount of ALT and AST.…”
Section: Resultssupporting
confidence: 92%
“…The present results also supported by the findings of Bano et al [ 30 ] determined 20% decline in serum triglyceride level due to dietary intake of bitter gourd in diabetic rats. Hossain et al [ 27 ] observed significant elevation in triglycerides level (47.02%) in diabetic control rat groups. However, bitter gourd at the rate of 250, 500, 750 mg reduced the triglyceride level to 30.30%, 33.84 and 37.43%, respectively.…”
BackgroundCardiovascular diseases and diabetes are responsible for large number of deaths throughout the globe. Bitter gourd has the potential to become a component of the diet or a dietary supplement for diabetic and pre-diabetic patients owing to the presence of insulin like molecules. Recent investigations have suggested that bitter gourd extracts may ameliorate high fat diet induced obesity and hyperlipidemia in animal models. Moreover, its supplements in food result in lowering weight gain and visceral fat mass.MethodsThe current study was designed to investigate the nutraceutical potential of skin, flesh and whole fruit of bitter gourd cultivars against hyperglycemia and hyperlipidemia. For the purpose, various bitter gourd cultivars were procured from local market. Bio-evaluation studies were carried out on biochemical parameters using rodent experiment model.ResultsFrom results, it was revealed that maximum reduction in blood glucose skin 1.06%, flesh 2.65%, whole fruit 4.29%, total cholesterol skin 6.60%, flesh 6.04%, whole fruit 6.70%, low density lipoprotein skin 5.55%, flesh 6.81%, whole fruit 6.60%, and triglycerides skin 0.04%, flesh 3.38%, whole fruit 2.02%, were observed. Moreover, insulin skin 2.14%, flesh 3.52%, whole fruit 2.73%, production was slightly enhanced with improved levels of high density lipoprotein in whole fruit of bitter gourd.ConclusionOverwhelmingly, it may be inferred here that bitter gourd holds the potential to significantly improve diabetic conditions and associated late complications with no ill effects on body organs.
“…Shetty et al [ 25 ] also found a marginal increase in body weight of diabetic rats fed with diet containing bitter gourd. Similar findings by Hossain et al [ 27 ] also strengthen the current results that body weight of diabetic groups treated with bitter gourd was higher than the untreated diabetic group. Fig.…”
Section: Resultssupporting
confidence: 92%
“…Serum creatinine and urea concentration was also remained in normal ranges due to feeding of bitter gourd in diet. The current data is comparable to the earlier investigations of Hossain et al [ 27 ] confirmed a reduction in serum ALP, ALT and AST of rats treated with bitter gourd extract. In another study noted that bitter gourd is helpful in reducing the amount of ALT and AST.…”
Section: Resultssupporting
confidence: 92%
“…The present results also supported by the findings of Bano et al [ 30 ] determined 20% decline in serum triglyceride level due to dietary intake of bitter gourd in diabetic rats. Hossain et al [ 27 ] observed significant elevation in triglycerides level (47.02%) in diabetic control rat groups. However, bitter gourd at the rate of 250, 500, 750 mg reduced the triglyceride level to 30.30%, 33.84 and 37.43%, respectively.…”
BackgroundCardiovascular diseases and diabetes are responsible for large number of deaths throughout the globe. Bitter gourd has the potential to become a component of the diet or a dietary supplement for diabetic and pre-diabetic patients owing to the presence of insulin like molecules. Recent investigations have suggested that bitter gourd extracts may ameliorate high fat diet induced obesity and hyperlipidemia in animal models. Moreover, its supplements in food result in lowering weight gain and visceral fat mass.MethodsThe current study was designed to investigate the nutraceutical potential of skin, flesh and whole fruit of bitter gourd cultivars against hyperglycemia and hyperlipidemia. For the purpose, various bitter gourd cultivars were procured from local market. Bio-evaluation studies were carried out on biochemical parameters using rodent experiment model.ResultsFrom results, it was revealed that maximum reduction in blood glucose skin 1.06%, flesh 2.65%, whole fruit 4.29%, total cholesterol skin 6.60%, flesh 6.04%, whole fruit 6.70%, low density lipoprotein skin 5.55%, flesh 6.81%, whole fruit 6.60%, and triglycerides skin 0.04%, flesh 3.38%, whole fruit 2.02%, were observed. Moreover, insulin skin 2.14%, flesh 3.52%, whole fruit 2.73%, production was slightly enhanced with improved levels of high density lipoprotein in whole fruit of bitter gourd.ConclusionOverwhelmingly, it may be inferred here that bitter gourd holds the potential to significantly improve diabetic conditions and associated late complications with no ill effects on body organs.
“…Examples of such studies are: Akter, Mahabub-Uz-Zaman, and Rahman, 2013; Al-Amin, Uddin, Rizwan, and Islam, 2013; Ali et al, 1993; Amran, Sultan, Rahman, and Rashid, 2013; Bhuyan, Rokeya, Masum, Hossain, and Mahmud, 2010; Borhanuddin, Shamsuzzoha, and Hussain, 1994b; A. Chowdhury and Biswas, 2012; A. R. Das, Mostofa, Hoque, Das, and Sarkar, 2010; Habib and Gafur, 2003; J. M. A. Hannan et al, 2003; E. Haque, Saha, Islam, and Islam, 2012; M. A. Hossain et al, 2012; Md Alamgir Hossain, Roy, Ahmed, Chowdhury, and Rashid, 2007b; M. Z. Hossain, Shibib, and Rahman, 1992; Islam et al, 2009; M. A. Islam et al, 2011; I. A. Jahan et al, 2009; Mostofa et al, 2007b; Mowl, Alauddin, Rahman, and Ahmed, 2009; Rafiq, Sherajee, Nishiyama, Sufiun, and Mostofa, 2009; Md Masudur Rahman, Hossain, Siddique, Biplab, and Uddin, 2012b; Md Mahfuzur Rahman, Sayeed, Haque, Hassan, and Islam, 2012; M. W. Rahman et al, 2005; Rokeya, Bhowmik, Khan, and Khter, 2009; M. G. Roy et al, 2010; Shahreen et al, 2012; Shibib, Khan, and Rahman, 1993; Sikder, Kaisar, Rahman, Hussain, and Rashid, 2011; Talukder, Khan, Uddin, Jahan, and Alam, 2012; Urmi et al, 2012; Zulfiker et al, 2011 [ 222 , 223 , 224 , 225 , 226 , 227 , 228 , 229 , 230 , 231 , 232 , 233 , 234 , 235 , 236 , 237 , 238 , 239 , 240 , 241 , 242 , 243 , 244 , 245 , 246 , 247 , 248 , 249 , 250 , 251 , 252 ]. These scientific studies emphasized the correlation among traditional use and the pharmacological properties of antidiabetic plants.…”
Section: Phytochemical and Experimental Studies Of Antidiabetic Plants In Bangladeshmentioning
The use of conventional drugs to treat metabolic disorders and the pathological consequences of diabetes further increases the complications because of the side effects, and is sometimes burdensome due to relatively higher costs and occasionally painful route of administration of these drugs. Therefore, shifting to herbal medicine may be more effective, economical, have fewer side effects and might have minimal toxicity. The present review amasses a list of ethnomedicinal plants of 143 species belonging to 61 families, from distinctive domestic survey literature, reported to have been used to treat diabetes by the ethnic and local people of Bangladesh. Leaves of the medicinal plants were found leading in terms of their use, followed by fruits, whole plants, roots, seeds, bark, stems, flowers, and rhizomes. This review provides starting information leading to the search for and use of indigenous botanical resources to discover bioactive compounds for novel hypoglycemic drug development.
“…Hence, in the current study the aqueous extracts of M. charantia friuts, were estimated for the potential anti hyperlipidemic and antidiabetic effect on streptozotocin -induced diabetic rats and compared with the result with glibenclamide, a standard antidiabetic medicine [22]. The hypoglycemic probable mechanisms in M. charantiahave been recognized as glycosides, triterpenes, polysaccharides, saponins, alkaloids, steroids and proteins.…”
Momordica charantia is an herbal climber grown in tropical and subtropical regions, belonging to the Cucurbitaceae family. M. charantiacan be used as remedyagainst various diseases from ancient time. It has been used in various Asian traditional medicines for the treatment of cholera, bronchitis, anemia, blood diseases, ulcer, diarrhea, dysentery, gonorrhea rheumatism, gout, worms, colic, disease of liver and spleen, cancer and diabetes etc. The main constituents of M. charantia are triterpene, protein, steroid, alkaloid, inorganic, lipid, and phenolic compounds, which are responsible for biological and pharmacological activities including anti-diabetic, anti-cancerous and anti-tumorous, anti-microbial, anti-viral, anti-helmintic, antimalarial, anti-ulcerative and immunomodulatory. Combination of its Ayuervedic properties i.e. Gunna, Rasa and Virya (Dry, pungent, light, bitter and hot) makes it the real natures wonder. Hence the present study is planned to evaluate the biological characteristic like antioxident and antimicrobial properties of M. charantia. These activities will be sassessed by using different assay viz. total phenolics, total flavonols and scavenging assay for 1,1, diphenyl-2-picrylhydrazyl (DPPH). The antimicrobial activity will be evaluated by disc diffusion method.
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