Antihyperglycemic and neuroprotective effects of Wattakaka volubilis (L.f.) Stapf root against streptozotocin induced diabetes

Haroon, Hajira; Murali, Anita

doi:10.1590/s1984-82502016000300007

Cited by 7 publications

(4 citation statements)

References 36 publications

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“…The rats were considered as diabetic, if their blood glucose values above 250 mg/dl. After 7 days of stabilization, the plant extracts and standard drugs were given to respective groups for 21 days [2].…”

Section: Experimental Induction Of Diabetesmentioning

confidence: 99%

“…Diabetes is a metabolic problem of multiple etiologies categorized by prolonged hyper-glycaemia resultant from failings in insulin production, insulin activity, or both [1]. Diabetic patients are predisposed to many problems associated with their disease and most prevalent problems in diabetes are diabetic neuropathy which affects about 50% of diabetic patients [2]. Diabetic neuropathy distresses pain fibres and motor neurons, causing foot ulcers otherwise damage.…”

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confidence: 99%

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Antihyperglycemic and neuroprotective activity of Adenanthera pavonina bark against streptozotocin induced diabetic rats

Abarnadevika¹,

Kavitha²,

Gopalasatheeskumar³

2022

jrp

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Worldwide diabetes and diabetic neuropathy is the highly prevalent healthcare problem. Herbal based therapy is an alternative and safe management of this problem. Adenanthera pavonina is an important medicinal plant having many of the medicinal values. This research aimed to evaluate the antihyperglycemic and neuroprotective activity of bark of Adenanthera pavonina. Hydro alcohol (50% methanol) was used as the solvent for extraction. Streptozotocin (55 mg/kg, i.p) induced diabetic rats were used for the evaluation of antihyperglycemic and neuroprotective activity. Diabetic rats were treated with hydro alcoholic bark extract of Adenanthera pavonina (HABEA) for 21 days. After treatment period blood glucose levels, SGOT, SGPT, Glutamate and Lipid peroxidase levels were decreased significantly in HABEA (200 and 400 mg/kg, p.o) treated rats. However, body weight, Serotonin, GABA, total protein and reduced glutathione levels were increased. And also behavioral parameter such as pain behavior (Hot Plate Method and Tail Immersion Method) and locomotor behavior (actophotometer) were significantly improved in HABEA (200 and 400 mg/kg, p.o) treated rats. These are the findings confirms that, the HABEA has significant antihyperglycemic and neuroprotective activity. Alkaloids, glycosides, flavonoids, saponin, phenolics and phytosterol present in the bark of Adenanthera pavonina may be the reason for its antihyperglycemic and neuroprotective activity. Further, this research will useful for the isolation of active principles from HABEA and determining its molecular mechanisms.

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Section: Experimental Induction Of Diabetesmentioning

confidence: 99%

mentioning

confidence: 99%

Antihyperglycemic and neuroprotective activity of Adenanthera pavonina bark against streptozotocin induced diabetic rats

Abarnadevika¹,

Kavitha²,

Gopalasatheeskumar³

2022

jrp

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“…(Asclepiadaceae) has been used in the traditional system for healing various diseases such as physical weakness, skin ailments, hemorrhoids, anti-inflammatory, antipyretic, analgesic, and antibacterial potential. Dregea volubilis has also shown promising results as larvicidal, [2] anti-leukemic, [3] antitumor, antioxidant [4] and anti-diabetic, [5] antihyperlipidemic, [6] and hepatoprotective agents. [7] Most of the pharmacological activities of D. volubilis are due to its strong antioxidant properties.…”

Section: Introductionmentioning

confidence: 99%

Development and Validation of Thin Layer Chromatography-Densitometric Method for Quantification of Kaempferol and Chlorogenic Acid in Methanolic Extract of Dragea Volubilis

Sharma

Gill

Kumar

2022

APJHS

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The present study aims to prepare a methanolic extract of Dragea volubilis and to quantitatively estimate kaempferol and chlorogenic acid using newly developed and validated method of high-performance thin layer chromatography (HPTLC) using TLC densitometry technique. Dried leaves obtained from D. volubilis were defatted with petroleum ether and extracted in a Soxhlet extractor with methanol. The solvent was evaporated using a Rota evaporator. Quantitative analysis of the extract was done using TLC and HPTLC. A mixture of toluene: ethyl acetate: glacial acetic acid (5.5:4:0.5) for kaempferol and ethyl acetate: acetic acid: water (7:1.5:1.5) for chlorogenic acid was used as a mobile phase. The chromatography was performed on a TLC plate precoated with silica gel GF254 and the developed TLC plates were visualized and quantified at 367 nm and 327 nm for kaempferol and chlorogenic acid, respectively. The percentage yield was found to be 0.0397 ± 0.0001 and 0.0755 ± 0.0000 for kaempferol and 0.0755 ± 0.0000 for chlorogenic acid. Rf. values 0.95 and 0.61 were observed for kaempferol and chlorogenic acid, respectively. The method was validated for instrumental precision, repeatability, coefficient of determination (r2), linearity range (ng), LOD (ng), LOQ (ng), and intra-day and inter-day precision for both kaempferol and chlorogenic acid, and all the parameters were found to be within the acceptable range as per the ICH guidelines. The newly developed HPTLC method was found to be prompt, cost-effective, precisely accurate, and reproducible for the qualitative as well as quantitative analysis of kaempferol and chlorogenic acid in methanolic extract of D. volubilis.

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“…It affects pain fibers, motor neurons, and autonomic nervous system. 3 It results in large economic costs for its care. 4 , 5 , 6 Various kinds of neuropathy include peripheral neuropathy, proximal neuropathy, autonomic neuropathy, and focal neuropathy.…”

Section: Introductionmentioning

confidence: 99%

Molsidomine ameliorates diabetic peripheral neuropathy complications in Wistar rats

Nayak

Minaz

Pasha

2021

Anim Models and Exp Med

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Diabetes mellitus (DM) prevalence is increasing at an alarming rate as it was 381 million people globally in 2013 and is estimated to be 463 million people in 2019 rising to 578 million by 2030. It is a disease with high rate of complications such as neuropathy, nephropathy, retinopathy, erectile dysfunction etc. 1,2 Diabetic neuropathy is a family of disorders that damage the different regions of the nervous system, either individually or in combination. It affects pain fibres, motor neurons and autonomic nervous system. 3 It results in large economic costs for its care. [4][5][6] The various kind of neuropathies include peripheral neuropathy, proximal neuropathy, autonomic neuropathy and focal neuropathy. 7 There are a number of reasons for the pathogenesis of diabetic neuropathy and polyol pathway of glucose metabolism is thought as one of the major mechanism. 8 Peripheral neuropathy is a type of nerve damage that usually affects feet and legs and sometimes hands and arms. 9 It is proved that reactive oxygen species (ROS) plays a significant role in the pathophysiology of neuropathic pain in diabetes. 10 Out of all diabetic patients, 50% of patients develop neuropathy and painful neuropathy ranges from 10% to 20% in patients with diabetes. Diabetic patients can experience nerve problems at any time and the problem increases with age, weight and duration. 5 The complications across various countries varies from 10% to 30% and it is higher in developed countries than in developing countries. These complications can lead to painful symptoms and can affect quality of life of the patient. The treatment for the painful diabetic

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Antihyperglycemic and neuroprotective effects of Wattakaka volubilis (L.f.) Stapf root against streptozotocin induced diabetes

Cited by 7 publications

References 36 publications

Antihyperglycemic and neuroprotective activity of Adenanthera pavonina bark against streptozotocin induced diabetic rats

Antihyperglycemic and neuroprotective activity of Adenanthera pavonina bark against streptozotocin induced diabetic rats

Development and Validation of Thin Layer Chromatography-Densitometric Method for Quantification of Kaempferol and Chlorogenic Acid in Methanolic Extract of Dragea Volubilis

Molsidomine ameliorates diabetic peripheral neuropathy complications in Wistar rats

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