Antihyperglycemic, Antihyperlipidemic and Antiapoptotic Activities of Micromelum minutum Seeds in Diabetic Rats

Koriem, Khaled MM

doi:10.4172/1747-0862.s1-004

Cited by 5 publications

(9 citation statements)

References 32 publications

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“…Hence, the present study recommends further investigation of the biological and biochemical activities of both Anodendron species. Koriem et al (2013) demonstrated the antihyperglycemic, antihyperlipidemic and antiapoptotic activities of Micromelum minutum, which are all related to Microminutinin coumarin ingredient of the plant seeds. Identified chemical constituents for M. minutum also have potential biological property containing coumarins as potent cytotoxic agents against the T-lymphoblastic leukemia cell line (Susidarti et al 2009).…”

Section: Several Bioactive Compounds and Essential Oils Of Othermentioning

confidence: 93%

Ethnomedicinal appraisal and conservation status of medicinal plants among the Manobo tribe of Bayugan City, Philippines

et al. 2020

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Abstract. Dapar MLG, Meve U, Liede-Schumann S, Alejandro GJD. 2020. Ethnomedicinal appraisal and conservation status of medicinal plants among the Manobo tribe of Bayugan City, Philippines. Biodiversitas 21: 3843-3855. Manobo tribe is one of the most populated indigenous communities in the Philippines clustered in various parts of Mindanao archipelago with distinct cultural traditions and medicinal practices. This study aims to document the Agusan Manobo tribe medicinal plant uses and knowledge and to assess the conservation status of their medicinal plants found in upland ancestral lands where ethnomedicinal practices still prevail. Ethnomedicinal data were gathered from 95 key informants through semi-structured interviews, focus group discussions, and guided field walks in five selected upland barangays of Bayugan City. Family importance value (FIV) and relative frequency of citation (RFC) were quantified. The conservation status of their medicinal plants was assessed based on the international and national listing of threatened species. A total of 90 species belonging to 82 genera and 41 families were identified as ethnomedicinally important. Highest FIV (98.9) was reported for Piperaceae in treatment for skin diseases and infections. The most cited medicinal plant species was Piper decumanum L. (RFC=0.95), which is primarily used in treatment for insect and snake bites. Conservation assessment revealed that the five upland areas of the Agusan Manobo tribe are habitats of endemic, endangered, vulnerable and threatened species. The results of this study present the rich ethnomedicinal knowledge of Agusan Manobo cultural community, which could serve as a useful source of information to improve community healthcare and environmental conservation and management. Local people and the government should actively participate in shared management responsibilities for viable conservation strategies and sustainable use of the cultural community resources.

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Section: Several Bioactive Compounds and Essential Oils Of Othermentioning

confidence: 93%

Ethnomedicinal appraisal and conservation status of medicinal plants among the Manobo tribe of Bayugan City, Philippines

et al. 2020

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“…Microminutin (19) was isolated from the acetone extract of the stems of M. minutum. 25 Some coumarins, such as 7-methoxy-8-(4′-methyl-3′-fura nyl)coumarin (20), microminutin B (21), microminutin C (22), and micromeloside A (23), were isolated from the finely powdered fruits of M. falcatum 4 (Figure 2). In 2014, Kouloura et al reported microcoumaririn (24) from the leaves of M. falcatum.…”

Section: Coumarinsmentioning

confidence: 99%

“…28 (−) Decursinol (30) was isolated from the finely powdered fruits of M. falcatum. 4 One-prenylated coumarins named micromarin-A (31), -B (32), and -C (33) were isolated from the seeds of M. minutum 22 and fruits of M. falcatum 16 (Figure 3). (35), and 3-hydroxy-4-methoxy-4-(7-methoxy-2-oxo-2H-chromen-8-yl) −2-methylenebutyl-3-ethylbutanoate (36), were isolated from the finely powdered fruits of M. falcatum 4,16 (Figure 4).…”

Section: Coumarinsmentioning

confidence: 99%

Phytoconstituents of Genus Micromelum and Their Bioactivity—a Review

Thant

Aminah

Kristanti

et al. 2020

Natural Product Communications

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The genus Micromelum belongs to the Rutaceae family. As its rich bioactive constituents its stems, flowers, leaves, and roots have been used in traditional medicine, for the treatment of various diseases from ancient time. Phytochemically, many bioactive compounds, including coumarins, polyoxygenated flavonoids, phenylpropanoic acid derivatives, quinolone alkaloids, and also carbazole alkaloids, have been reported as secondary metabolites of the Micromelum spp. including many new compounds. Therefore, Micromelum spp. are considered potential for drug leads. In this article, we present an overview of secondary metabolites isolated from genus Micromelum and their bioactivities that have been reported between 1982 and 2019.

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“…M. koenigii and M. minutum reduce the number of medications needed to treat many metabolic and non-communicable diseases, including diabetics, cancers, cardiovascular diseases, and obesity [ 9 , 10 , 11 , 12 ]. The majority of metabolic and non-communicable diseases are linked with higher mortality and morbidity rates [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

Phytochemical screening, total polyphenol, flavonoid content, in vitro antioxidant and antibacterial activities of Sri Lankan varieties of Murraya koenigii and Micromelum minutum leaves

Abeysinghe

Kumara

Kaushalya

et al. 2021

Heliyon

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The use of plant materials in traditional medicine as a significant ingredient in synthesizing drugs in the form of decoctions had played a vital role due to their potential therapeutic action. The curry leaves, Murraya koenigii, and Micromelum minutum are two most common aromatic herbs widespread in Sri Lanka and many other Asian countries. They are rich in nutrition and exert several medicinal properties such as antidiabetic, antioxidant, antimicrobial, anti-inflammatory, and anti-carcinogenic due to various essential phytochemicals, minerals, and trace minerals. In this study, we determined the proximate composition, in vitro antioxidant activity, total phenol (TPC), flavonoid content (TFC), and antibacterial activity in both species using standard methods. Results showed that both species varied greatly in nutritional composition, antioxidant, and antibacterial activities. The nutrient composition in terms of ash, crude protein, and fat was significantly high in M. koenigii based on dry weight basis. In vitro antioxidant potential of M. koenigii and M. minutum was evaluated by means of the DPPH radical scavenging assay, and the IC 50 values of M. koenigii and M. minutum were 107 AE 2 μg/mL and 208 AE 4 μg/mL, respectively. The TPC and TFC of M. koenigii were 101 AE 1 mg GAE/g and 9.75 AE 0.05 mg QE/g, and M. minutum were 80 AE 2 mg GAE/g and 9.16 AE 0.02 mg QE/g respectively. The antibacterial study was assessed against three bacterial strains. The study showed the highest inhibitory activity for M. koenigii and M. minutum against Staphylococcus aureus and Escherichia coli, respectively at 1.0 mg/mL concentration. The study indicated that M. koenigii possessed a significantly high TPC, and TFC correlated with higher antibacterial and antioxidant activity than M. minutum.

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Antihyperglycemic, Antihyperlipidemic and Antiapoptotic Activities of Micromelum minutum Seeds in Diabetic Rats

Cited by 5 publications

References 32 publications

Ethnomedicinal appraisal and conservation status of medicinal plants among the Manobo tribe of Bayugan City, Philippines

Ethnomedicinal appraisal and conservation status of medicinal plants among the Manobo tribe of Bayugan City, Philippines

Phytoconstituents of Genus Micromelum and Their Bioactivity—a Review

Phytochemical screening, total polyphenol, flavonoid content, in vitro antioxidant and antibacterial activities of Sri Lankan varieties of Murraya koenigii and Micromelum minutum leaves

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