Antihyperglycemic effects of Cajanus cajan L. (pigeon pea) ethanolic extract on the blood glucose levels of ICR mice (Mus musculus L.)

Abstract

Background: Diabetes mellitus is a metabolic disease that is usually associated with abnormalities in the metabolism of different substrates leading to high blood glucose levels (BGL). Aims and Objectives: Aims and objectives are to evaluate the effects of ethanolic extracts of Cajanus cajan (CCEE) leaves on its antihyperglycemic effects on BGL of normoglycemic mice. Materials and Methods: 45, 5-week-old female, mice were divided into five groups and were administered with either double distilled water, glimepiride, or CCEE. Results: Baseline BGLs were measured before the induction of hyperglycemia by glucose loading. 30 min after, the BGLs were measured again and ranged between 167.667 and 185.778 mg/dL. Immediately after the hyperglycemic BGLs were measured, the corresponding treatments were administered. Subsequently, three blood collections were done spanning 3 h with 1 h interval. The treatment doses were observed to have a faster onset than the positive control supported by the fact that the treatment groups had significant differences (P < 0.05) with their respective hyperglycemic BGLs on the 1 st h, while the positive control group exhibited significant difference with its hyperglycemic BGL on the 2 nd h. The hypoglycemic effect of the positive control peaked at the 3 rd h with 67.33 mg/dL and surpassed the hypoglycemic effect of the medium-and high-dose groups with 83.778 and 98.556 mg/dL, respectively. The low-dose group did not have significant difference with the negative control group past the 1 st h suggesting that this dosage has a weak hypoglycemic effect. Conclusion: These results indicate that the CCEE leaves were able to produce hypoglycemic effects at doses between 400 and 800 mg/kg bodyweight.

Antidiabetic effects of Cycas edentata aqueous leaf extract on the blood glucose levels of alloxan-induced diabetic imprinting control regions mice (Mus musculus L.)

“…The plant was studied to contain saponins and may also have the same effect on diabetic mice. [27] There are different attributes of how saponins in plants can exert its antidiabetic effects. Some of the most common is that it can release insulin from the pancreas, reduce activity of glucose-6-phosphatase in the liver, and also alpha-glycosidase inhibition.…”

Review on Plants for Management of Diabetes in India: An Ethno- Botanical and Pharmacological Perspective

“…antihyperglycemic activity when normal glycemic mice were fed with ethanolic extract of C. cajan leaves 77 .…”

Dissemination, training on pigeon pea utilization and evaluation of farmers’ acceptability of the products at Erin Oke, Osun state, Nigeria

“…The legume has the unique qualities desired by people running away from fatty foods and desiring vegetable protein to animal fats. Other information includes its anti-inflammatory, anti-oxidant properties (Lai et al, 2012) and anti-diabetic properties Manzo and Vitor (2017). It is also cheaper in cost than soybean and cowpea.…”

“…It is being reported to be low in lipoprotein cholesterol (Mayilvaganan et al, 2004). Its anti-antioxidant and inflammatory properties have also been reported (Lai et al, 2012); also its antihyperglycermic (antidiabetic) effect has been shown by Manzo and Vitor (2017). It has been developed at IAR&T into a number of food products with cassava and maize to improve the nutritional quality of these staples Arowora, 2013, Fasoyiro et al, 2013).…”