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Background: Diabetes mellitus is a metabolic disease that is usually associated with abnormalities in the metabolism of different substrates leading to high blood glucose levels (BGL). Aims and Objectives: Aims and objectives are to evaluate the effects of ethanolic extracts of Cajanus cajan (CCEE) leaves on its antihyperglycemic effects on BGL of normoglycemic mice. Materials and Methods: 45, 5-week-old female, mice were divided into five groups and were administered with either double distilled water, glimepiride, or CCEE. Results: Baseline BGLs were measured before the induction of hyperglycemia by glucose loading. 30 min after, the BGLs were measured again and ranged between 167.667 and 185.778 mg/dL. Immediately after the hyperglycemic BGLs were measured, the corresponding treatments were administered. Subsequently, three blood collections were done spanning 3 h with 1 h interval. The treatment doses were observed to have a faster onset than the positive control supported by the fact that the treatment groups had significant differences (P < 0.05) with their respective hyperglycemic BGLs on the 1 st h, while the positive control group exhibited significant difference with its hyperglycemic BGL on the 2 nd h. The hypoglycemic effect of the positive control peaked at the 3 rd h with 67.33 mg/dL and surpassed the hypoglycemic effect of the medium-and high-dose groups with 83.778 and 98.556 mg/dL, respectively. The low-dose group did not have significant difference with the negative control group past the 1 st h suggesting that this dosage has a weak hypoglycemic effect. Conclusion: These results indicate that the CCEE leaves were able to produce hypoglycemic effects at doses between 400 and 800 mg/kg bodyweight.

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