Antihyperlipidemic Activities and Hematological Properties of Ethanol Extract of Blighia Sapida Koenig Bark in Alloxan-Induced Diabetic Rats

Abstract

Blighia sapida (BS) has been shown to be rich sources of antioxidant, thus, we evaluated effects of B. sapida Koenig stem bark ethanol extract (BSE) on lipid metabolism and hematological indices in diabetes rats. Thirty male rats were divided into six groups of five rats each. Diabetes was elicited by intraperitoneal injection of alloxan (65 mg/kg body weight) once and orally administered with glibenclamide (5 mg/kg), B. sapida extract (50, 100 and 150 mg/kg body weight (bw) once daily for 21 days. Serum lipid profile, markers of hepato-renal toxicity and hematological indices were examined using automated analyzer. Data were analyzed using one-way ANOVA and p < 0.05 was considered to be statistically different. Diabetic untreated animals showed considerably elevated total cholesterol p < 0.05, also, significant increase in AST, ALT, ALP, urea and creatinine compared to control. Triglycerides, LDL-c, VLDL-c, AI and CRI decreased with extract administration and HDL-c increased considerable compared to untreated diabetic rats. Furthermore, significant lower hemoglobin (Hb) levels, packed cell volume (PCV), red blood cells (RBCs) levels, white blood cells (WBCs) compared to normal animals was recorded in the untreated group. These changes were returned to normal after the administration of extract 50, 100 and 150 mg/ kg body weight. Hence, these effects were most prominent in the animals treated with 150 mg/kg body weight of B. sapida bark. This indicates that B. sapida stem bark possess anti-hyperlipidemic activity and improved the biochemical parameters within the hematological profile of diabetic rats.

Antidiabetic activity of avocado seeds (Persea americana Mill.) in diabetic rats via activation of PI3K/AKT signaling pathway

“…Dyslipidemia, increments in the concentrations of TC, TG, and alterations in lipoprotein components, is a recognized challenge in diabetic patients 41 , 42 . Also, the high concentrations of LDL-c and AI induced by alloxan imply a propensity for cardiovascular issues 42 .…”

“…Also, the high concentrations of LDL-c and AI induced by alloxan imply a propensity for cardiovascular issues 42 . The increased levels of TC in diabetic animals are due to the inactivation of lipoprotein lipase 41 , 42 . The ability of AEPAS to restore the deranged metabolic pathways could be the result of lipase inhibition via insulin and a subsequent reduction in the rate of lipid degradation, biotransformation of free fatty acids to phospholipids.…”

Antidiabetic Activity of Elephant Grass (Cenchrus Purpureus (Schumach.) Morrone) via Activation of PI3K/AkT Signaling Pathway, Oxidative Stress Inhibition, and Apoptosis in Wistar Rats

“…To reduce the global burden of diabetes mellitus (DM), researchers are searching for newer therapies, especially the use of natural plants, which are readily available and pose fewer or no side effects ( Balogun and Ashafa 2017 ). Some drugs used in treating diabetes are known to have limited efficacy over time ( Ojo O. A. et al, 2020 ).…”

“…DM is a common result of a defect in the secretion or action of insulin and sometimes both Ojo et al, 2017 ; Ojo O. A. et al, 2020 ).…”

“…The use of alloxan at a low dose causes partial destruction of the hepatic beta cells. Thus, the plant extract may have led to a regeneration of the surviving beta cells ( Ojo O. A. et al, 2020 ).…”