Antihyperlipidemic Agents

Moss, Jack N.; Dajani, Esam Z.

doi:10.1016/b978-0-12-704252-7.50016-3

Cited by 22 publications

(11 citation statements)

References 67 publications

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“…4) The administration of Triton WR1339, a non-ionic detergent, to fasted or non-fasted mice and rats results in the elevation of plasma cholesterol and triglyceride levels. 5,6) The mechanism underlying this phenomenon has been suggested to be a``trapping'' of cholesterol and triglyceride in the blood compartment [7][8][9] and subsequently to reduce the in‰ux of plasma into the liver. 5) Furthermore, it has been shown that Triton WR1339 increases hydroxymethylglutaryl coenzyme A reductase (HMG-CoA reductase) activity in the liver, 10) and that an increase of the concentration of triglyceride in plasma is generally assumed to be the result of the inhibition of lipoprotein lipase activity.…”

Section: Effects Of γ-Terpinene On Lipid Concentrations Inmentioning

confidence: 99%

Effects of γ-Terpinene on Lipid Concentrations in Serum Using Triton WR1339-Treated Rats

Takahashi¹,

Inaba²,

Kuwahara³

et al. 2003

Bioscience, Biotechnology, and Biochemistry

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We studied lipid metabolism to evaluate the effects of gamma-terpinene on suppression of increases in serum lipid concentrations using Triton WR1339-treated rats. At 6 hr after Triton WR1339 injection, the total cholesterol and triglyceride concentrations in the gamma-terpinene group underwent statistically significant decreases (18.3 and 30.3%, respectively) compared with those of the Triton-treated group.

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Section: Effects Of γ-Terpinene On Lipid Concentrations Inmentioning

confidence: 99%

Effects of γ-Terpinene on Lipid Concentrations in Serum Using Triton WR1339-Treated Rats

Takahashi¹,

Inaba²,

Kuwahara³

et al. 2003

Bioscience, Biotechnology, and Biochemistry

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“…It is evident that the decoction is active against diet-induced hypercholesterolaemia. This hypercholesterolaemia is of an exogenous nature; endogenous cholesterol biosynthesis proceeds in this experimental condition at a very low rate, and the effect of the decoction seemed to involve inhibition of cholesterol intestinal absorption and enhancement of cholesterol degradation ( Moss and Dajani, 1972). It is evident that the decoction of the Sclerocarya birroea bark significantly influences some metabolic activities in the rat.…”

Section: Resultsmentioning

confidence: 95%

Effects of Sclerocarya birroea Hochst. extract on some metabolic activities in the rat

Trovato

Kirjavainen

Galati

et al. 1995

Phytotherapy Research

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“…Therefore, therapists consider the treatment of hyperlipidemia one of the major approaches towards decelerating the atherogenic process [3].…”

Section: Introductionmentioning

confidence: 99%

Anti-hyperlipidemic activity of an extract from roots and rhizomes of Panicum repens L. on high cholesterol diet-induced hyperlipidemia in rats

El-Tantawy

Temraz²,

Hozaien

et al. 2015

Zeitschrift Für Naturforschung C

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The hypolipidemic effect of an ethanolic extract from the roots and rhizomes of Panicum repens L. was investigated in rats suffering from high-cholesterol, diet-induced hyperlipidemia, and the phytochemicals in the extract were analyzed. The extract was administered p.o. in doses of 250 mg/kg/day together with cholesterol at a dose of 100 mg/kg/day for 7 weeks. The high-cholesterol diet caused a significant increase in total lipids, total cholesterol (TC), total triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), and the atherogenic index, whereas the level of high-density lipoprotein cholesterol (HDL-C) was significantly decreased. Administration of the P. repens extract (p<0.05) significantly reduced the rise of the serum levels of total lipids, TC, TG, and LDL-C, as well as the atherogenic index, whereas it significantly increased (p<0.05) the level of HDL-C. HPLC analysis of the phenolics and flavonoids in the extract revealed the presence of gallic acid, chlorogenic acid, chicoric acid, primulic acid, rutin, apigenin-7-glucoside, and quercetin. In conclusion, the P. repens extract was found to possess hypolipidemic activity in high-fat, diet-induced hyperlipidemic rats.

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Antihyperlipidemic Agents

Cited by 22 publications

References 67 publications

Effects of γ-Terpinene on Lipid Concentrations in Serum Using Triton WR1339-Treated Rats

Effects of γ-Terpinene on Lipid Concentrations in Serum Using Triton WR1339-Treated Rats

Effects of Sclerocarya birroea Hochst. extract on some metabolic activities in the rat

Anti-hyperlipidemic activity of an extract from roots and rhizomes of Panicum repens L. on high cholesterol diet-induced hyperlipidemia in rats

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