Antihyperlipidemic and hepatoprotective activities of residue polysaccharide from Cordyceps militaris SU-12

Wang, Liqin; Xu, Nuo; Zhang, Jianjun; Zhao, Huajie; Lin, Lin; Shi, Jin-Xing

doi:10.1016/j.carbpol.2015.06.016

Cited by 110 publications

(49 citation statements)

References 26 publications

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“…35 . The oil phase consisted of a mixture of 25 g of lard oil, 10 g of cholesterol, 1 g of methylthiouracil and 25 mL of Tween-80.…”

Section: Methodsmentioning

confidence: 99%

Hepatoprotective and in vitro antioxidant effects of native depolymerised-exopolysaccharides derived from Termitomyces albuminosus

Zhao

Zhang

et al. 2017

Sci Rep

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In this study, native depolymerised-exopolysaccharides (DEPS) were successfully derived from the exopolysaccharides (EPS) of Termitomyces albuminosus, and its hepatoprotective effects against a high-fat emulsion and in vitro antioxidant activities were investigated. Based on the results of in vitro assays, DEPS showed superior antioxidant activities compared with EPS dose-dependently. According to the in vivo assays both EPS and DEPS significantly decreased the lipid levels, improved the enzymatic activities, and reduced lipid peroxidation in both serum and hepatic homogenates. Furthermore, EPS and DEPS attenuated the high-fat emulsion-induced histopathological injury to the liver. Both EPS and DEPS might be used as natural drugs to treat and protect against hyperlipidaemia and liver injury induced by a high-fat emulsion. In addition, based on the results of GC and HPLC analyses, rhamnose and low molecular weight compounds may play an important role in contributing to the antioxidant activities of EPS and DEPS.

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“…35 . The oil phase consisted of a mixture of 25 g of lard oil, 10 g of cholesterol, 1 g of methylthiouracil and 25 mL of Tween-80.…”

Section: Methodsmentioning

confidence: 99%

Hepatoprotective and in vitro antioxidant effects of native depolymerised-exopolysaccharides derived from Termitomyces albuminosus

Zhao

Zhang

et al. 2017

Sci Rep

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“…The evidences obtained from lab revealed that the liver index, TC and TG levels in liver were obvious decrease after treatment with PEP, which reduction rate was 16.5% (p < 0.01) for liver index, 28.4% (p < 0.01) for TC level and 37.0% (p < 0.01) for TG in the PEP-M group, respectively (Table 2). Since the activities of AST and ALT in serum have been used as biochemical markers for liver damage [28], lowering the liver lipid is an important approach to prevent or treatment of fatty liver [2]. Our data therefore demonstrated that a high-fat diet induced hyperlipidemia and serious liver damage as evidenced by significant elevations of AST and ALT (Table 3).…”

Section: Discussionmentioning

confidence: 55%

“…Hyperlipidemia is one of the major endocrine diseases and has been incriminated as a contributory factor of atherosclerosis [1]. Epidemiological studies have demonstrated strong causal relations between lipid parameters level and hyperlipidemia [2,3]. The excess intake of cholesterol-rich or high-fat diet will lead to metabolic dysfunctions of lipid, resulting in hyperlipidemia.…”

Section: Introductionmentioning

confidence: 99%

Antioxidant, Hypolipidemic and Hepatic Protective Activities of Polysaccharides from Phascolosoma esculenta

Jiang

Lin

et al. 2020

Marine Drugs

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The aims of this study were to investigate the antioxidant, hypolipidemic and hepatic protective effects of Phascolosoma esculenta polysaccharides (PEP). PEP was prepared from Phascolosoma esculenta by enzyme hydrolysis and its characterization was analyzed. The antioxidant activities of PEP were evaluated by the assays of scavenging 1,1-Diphenyl-2-picrylhydrazyl (DPPH), superoxide anion, hydroxyl radicals and chelating ferrous ion in vitro. It showed that PEP could scavenge radicals effectively and had favorable antioxidant activities. In the meantime, the hypolipidemic effect of PEP was investigated in vivo by using mice model fed with high-fat diet with or without PEP treatment. Compared with the hyperlipidemic mice without treatment, the serum levels of total cholesterol (TC) (30.1–35.7%, p < 0.01), triglyceride (TG) (24.5–50.8%, p < 0.01 or p < 0.05), low-density lipoprotein cholesterol (LDL-C) (49.6–56.8%, p < 0.01) and liver levels of TC (21.0–28.4%, p < 0.01), TG (23.8–37.0%, p < 0.01) decreased significantly, whereas serum high-density lipoprotein cholesterol (HDL-C) (47.7–59.9%, p < 0.01 or p < 0.05) increased significantly after treatment with different dosage of PEP (0.2, 0.4 and 0.8 g per kg body weight, respectively). In addition, superoxide dismutase (SOD) (10.2–22.2% and 18.8–26.9%, p < 0.05), glutathione peroxidase (GSH-Px) (11.9–15.4% and 26.6–30.4%, p < 0.05) activities in serum and liver enhanced markedly while aspartate aminotransferase (AST) (18.7–29.6% and 42.4–58.0%, p < 0.05), alanine transaminase (ALT) (42.7–46.0% and 31.2–42.2%, p < 0.05) activities, as well as the levels of malondialdehyde (MDA) (15.9–24.4% and 15.0–16.8%, p < 0.01 or p < 0.05) in serum and liver reduced markedly. Moreover, the histopathological observation of livers indicated that PEP could attenuate liver cell injury. The animal experimental results demonstrated that PEP exerted hypolipidemic and hepatoprotective roles in hyperlipidemic mice. In summary, our results above suggest that PEP might be a potential natural antioxidant and utilized as a therapeutic candidate for hyperlipidemia.

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“…Modern scientific studies demonstrate that mushrooms are an abundant source of a wide range of bioactive natural products. Polysaccharides are the best-known mushroom-derived substances, and have various biological activities, such as antitumor, immunomodulatory, antihyperlipidemic, hepatoprotective, antioxidative and anti-fatigue effects [1][2][3][4][5] . Polysaccharides from medicinal mushrooms such as Ganoderma lucidum, G. tsugae, G. applanatum, Cordyceps sinensis, C. militaris have been studied extensively [6][7][8][9][10] , and the research for new bioactive polysaccharide has been extended to other mushrooms.…”

Section: Introductionmentioning

confidence: 99%

Efficient Production of Exopolysaccharide by Submerged Fermentation of Hypsizygus marmoreus Using a Two-stage pH Control Strategy

Chen

Zhang

Xiao

et al. 2018

Chem.Biochem.Eng.Q.

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The effects of culture conditions and pH values on the exopolysaccharides (EPS) production by Hypsizygus marmoreus were investigated in this work. The results showed that the optimal carbon and nitrogen sources were glucose and yeast extract at concentrations of 30 g L -1 and 12.5 g L -1, respectively. In constant pH fermentation, high biomass concentration and the specific cell growth rate were achieved at pH 6.5, while high EPS concentration and the specific EPS production rate were obtained at pH 7.5, respectively. Based on kinetics analysis, a two-stage pH strategy was proposed in which pH was controlled at 6.5 to maintain high cell growth and glucose consumption in the first 48 h, and then shifted to 7.5 for increasing EPS production. The maximal EPS concentration reached 2.31 ± 0.07 g L -1 by applying this strategy. The EPS productivity (0.024 g L -1 h -1 ) increased 58.94 %, 172.7 % and 35.73 %, respectively, compared with that of the natural pH, and controlling pH at 6.5 and 7.5.

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Antihyperlipidemic and hepatoprotective activities of residue polysaccharide from Cordyceps militaris SU-12

Cited by 110 publications

References 26 publications

Hepatoprotective and in vitro antioxidant effects of native depolymerised-exopolysaccharides derived from Termitomyces albuminosus

Hepatoprotective and in vitro antioxidant effects of native depolymerised-exopolysaccharides derived from Termitomyces albuminosus

Antioxidant, Hypolipidemic and Hepatic Protective Activities of Polysaccharides from Phascolosoma esculenta

Efficient Production of Exopolysaccharide by Submerged Fermentation of Hypsizygus marmoreus Using a Two-stage pH Control Strategy

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