Antihyperlipidemic effect and increased antioxidant enzyme levels of aqueous extracts from Liupao tea and green tea in vivo

Abstract

Liupao tea (fermented dark tea) may improve the active function of hyperlipidemia. Utilizing a hyperlipidemia Sprague‐Dawley model and UPLC‐MS/MS metabolomics, we examined how the effect of Liupao and green tea extracts on hyperlipidemia and antoxidant enzyme levels and compared their constituents. The results showed that the two types of tea could reduce the levels of total cholesterol (TC), total triglyceride, and low‐density lipoprotein cholesterol (LDL‐C); increase the contents of bile acids and cholesterol in feces; and improve catalase and glutathione peroxidase (GSH‐Px) activities. Compared with the model control group, Liupao tea effectively reduced TC and LDL‐C levels by 39.53% and 58.55% and increased GSH‐Px activity in the liver by 67.07%, which was better than the effect of green tea. A total of 93 compounds were identified from two samples; the amounts of alkaloids and fatty acids increased compared with green tea, and ellagic acid, hypoxanthine, and theophylline with relatively high contents in Liupao tea had a significantly positive correlation with antihyperlipidemic and antioxidant effects. Therefore, Liupao tea had better antihyperlipidemic and antioxidant activities in vivo than green tea, which might be related to the relatively high content of some active substances.

Aging-Accelerated Mouse Prone 8 (SAMP8) Mice Experiment and Network Pharmacological Analysis of Aged Liupao Tea Aqueous Extract in Delaying the Decline Changes of the Body

“…Fermented tea such as dark tea contains more abundant oxidized polyphenols, theophylline, polysaccharides, ellagic acid and fatty acids, which can target to regulate AMPK and G-protein coupled receptors to promote lipid metabolism and delay degenerative diseases [ 98 , 99 , 100 ]. Liupao tea has the characteristics of red, thick, aged and mellow flavor quality.…”

A systemic review on Liubao tea: A time‐honored dark tea with distinctive raw materials, process techniques, chemical profiles, and biological activities

“…LBT aqueous extract elevated glutathione peroxidase (GSH‐Px) activities in serum and liver of the mice model of hyperlipidemia. EA and theophylline are reckoned as the main contributors to antioxidants ability of LBT (Huang et al., 2022). Among 32 teas, LBT demonstrated the most potent stimulating of GSH and superoxide dismutase (SOD), while suppressing malondialdehyde (MDA) in vivo (Cao et al., 2020).…”

“…LBT polysaccharides effectively suppressed body weight and the serum levels of TC and TG, promoted the secretion of BAs dose‐dependently, and initiated the coagulation through the intrinsic pathway (Mao et al., 2018). BAs and TC contents in feces were significantly elevated by LBT extract, implying their promoted effects on the BA synthesis and secretion, as well as lipids’ excretion (Huang et al., 2022). Lipid metabolic disorders were relieved by aged LBT via the downregulation of sterol‐regulatory element binding proteins‐1C and fatty acid synthetase, and the upregulation of PPAR‐α.…”

Purple tea: chemical characterization and evaluation as inhibitor of pancreatic lipase and fat digestion in mice

“…41 Similar observations of medium-or long-term effects have been made with several other tea varieties, including green tea. [42][43][44] It seems, thus, logical to conclude that most types of tea may exert beneficial effects on lipid metabolism, depending on the dose and time of treatment.…”