Antihyperlipidemic effects of apple peel extract in high-fat diet-induced hyperlipidemic rats

Susilowati, Retno; Jannah, Jauharotul; Maghfuroh, Zahrotul; Kusuma, Meike Tiya

doi:10.4103/japtr.japtr_28_20

Cited by 10 publications

(9 citation statements)

References 18 publications

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“…The more desired changes were observed in both: high-choline fed and high-fructose fed mice as apple peel supplementation led to HDL increase and TC, TG and LDL decrease [ 12 , 57 ]. Similar observations were made in hyperlipidemic rats, as apple peel supplementation significantly reduced serum LDL and increased HDL levels [ 58 ] and in diabetic rats, where a decrease in TC, LDL and TG with significant HDL elevation was observed [ 59 ]. This relationship was also present in tilapia, as apple peel powder supplementation reduced TC and TG levels in both the serum and liver [ 60 ].…”

Section: Resultssupporting

confidence: 70%

“…These differences might be caused by the variances in applied phenolic doses. It was calculated that human participants consumed approximately 306 mg/day of total phenolic compounds, while there were relatively higher doses used in the presented animal model studies, i.e., from 114 mg/kg to 1 g/kg [ 58 , 59 ]. The presented human study was also based on the small inhomogeneous metabolically group, so more studies in selected larger human groups could clarify this issue.…”

Section: Resultsmentioning

confidence: 99%

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Apple Peel Supplementation Potential in Metabolic Syndrome Prevention

Popiołek-Kalisz

Glibowski

2023

Life

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(1) Introduction: Apples are a source of bioactive substances, e.g., anthocyanidins and flavonols, and dietary fiber. Their highest concentrations are observed in the skin. Metabolic syndrome (MetS) is a set of conditions originally associated with obesity. Excessive adipose tissue accompanying obesity leads to chronic inflammation and metabolic disorders, which result in the development of dyslipidemia, elevated blood pressure, and glucose levels. Thus, supplementation of apple peels, a source of antioxidant substances and fiber, could potentially be a method supporting the prevention of MetS. This paper summarizes the results of available research on the potential impact of apple peel supplementation on the components of MetS. (2) Results: The results from in vitro and animal model studies indicate a positive effect of apple peel supplementation on lipid profile, glucose levels, and blood pressure regulation mediators. Only one human study was performed, and it showed that the consumption of apple peels had an effect on endothelial function but not on other clinical parameters. At the moment, there are no results from observations on large groups of people available. (3) Conclusions: The results of in vitro and animal-model studies indicate the potential of apple peel supplementation in MetS prevention, but it has not been clinically confirmed in human studies. Conducting large human studies could allow a definite clarification of the role of apple peel supplementation in MetS prevention.

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Section: Resultssupporting

confidence: 70%

Section: Resultsmentioning

confidence: 99%

Apple Peel Supplementation Potential in Metabolic Syndrome Prevention

Popiołek-Kalisz

Glibowski

2023

Life

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“…showed that oxidized LDL (oxLDL) promotes platelet aggregations through reduction of platelet NO; in turn, the activated platelets activate the uptake of oxLDL by macrophages. [ 24 ] This interaction leads to significant changes in the platelet indices as shown in the current study. Different studies have been shown that dyslipidemia may affect the metabolic activity of platelets, as oxLDL activates while HDL inhibits the atherogenic activity of platelets.…”

Section: Discussionsupporting

confidence: 58%

Role of dyslipidemia in the development of early-onset preeclampsia

Al-Maiahy

Al-Gareeb

Al-Kuraishy

2021

Journal of Advanced Pharmaceutical Technology &Amp; Research

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Preeclampsia (PE) is a gestational-related disease presented with hypertension, peripheral edema, and proteinuria after 20 weeks of gestation. In PE, there are various metabolic changes like dyslipidemia. In addition, both PE and dyslipidemia are associated with changes of platelet indices. Thus, objective of the current study was to illustrate the potential role of dyslipidemia and platelet changes in pregnant women with PE. This case–control study involved 37 preeclamptic pregnant women as compared to 24 healthy pregnant women as controls. Blood pressure profile, lipid profile, proteinuria, and platelet indices were measured. Blood pressure profile was higher in preeclamptic pregnant women as compared to the controls (P < 0.01). There was a significant dyslipidemic status in preeclamptic pregnant women compared with the controls (P < 0.01). Platetetcrit (PCT) and platelet count (PC) were lower in preeclamptic pregnant women compared with the controls (P = 0.001). On the other hand, platelet distribution width (PDW), mean platelet volume (MPV), and platelet-large cell ratio (P-LCR) were higher in the pregnant women with PE as compared with the controls (P = 0.001). PCT and PC were insignificantly linked, while P-LCR, MPV and PDW were significantly correlated with total cholesterol, triglyceride, low-density lipoprotein (LDL)/high-density lipoprotein (HDL) ratio, systolic blood pressure, DBP, and MAP in preeclamptic patients compared with women of normal pregnancy. Both dyslipidemia and alterations in the platelet indices are correlated with blood pressure profile in PE. High MPV and PDW in association with high LDL/HDL ratio in pregnant women herald risk of PE.

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“…Quercetin, hyperoside, rutin and chlorogenic acid from hawthorn have been reported to inhibit HMGCR activity, and there are synergistic effects between the monomers after the combination [ 70 ]. Furthermore, Susilowati et al demonstrated that quercetin, chlorogenic acid, epicatechin and catechin from apple peel have inhibitory effects on HMGCR targets by molecular docking tests and in vitro experiments, leading to a combined inhibition of cholesterol synthesis [ 135 ].…”

Section: The Synergistic Hypolipidemic Mechanismsmentioning

confidence: 99%

Synergistic Hypolipidemic Effects and Mechanisms of Phytochemicals: A Review

Liu

Kou

et al. 2022

Foods

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Hyperlipidemia, a chronic disorder of abnormal lipid metabolism, can induce obesity, diabetes, and cardiovascular and cerebrovascular diseases such as coronary heart disease, atherosclerosis, and hypertension. Increasing evidence indicates that phytochemicals may serve as a promising strategy for the prevention and management of hyperlipidemia and its complications. At the same time, the concept of synergistic hypolipidemic and its application in the food industry is rapidly increasing as a practical approach to preserve and improve the health-promoting effects of functional ingredients. The current review focuses on the effects of single phytochemicals on hyperlipidemia and its mechanisms. Due to the complexity of the lipid metabolism regulatory network, the synergistic regulation of different metabolic pathways or targets may be more effective than single pathways or targets in the treatment of hyperlipidemia. This review summarizes for the first time the synergistic hypolipidemic effects of different combinations of phytochemicals such as combinations of the same category of phytochemicals and combinations of different categories of phytochemicals. In addition, based on the different metabolic pathways or targets involved in synergistic effects, the possible mechanisms of synergistic hypolipidemic effects of the phytochemical combination are illustrated in this review. Hence, this review provides clues to boost more phytochemical synergistic hypolipidemic research and provides a theoretical basis for the development of phytochemicals with synergistic effects on hyperlipidemia and its complications.

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Antihyperlipidemic effects of apple peel extract in high-fat diet-induced hyperlipidemic rats

Cited by 10 publications

References 18 publications

Apple Peel Supplementation Potential in Metabolic Syndrome Prevention

Apple Peel Supplementation Potential in Metabolic Syndrome Prevention

Role of dyslipidemia in the development of early-onset preeclampsia

Synergistic Hypolipidemic Effects and Mechanisms of Phytochemicals: A Review

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