<p>Learning Strategies outdoor make kids can enjoy the fun<br />and really help the growth and development. A wide variety of areas<br />that exist in the outdoor play environment surrounded by nature<br />are natural so that children can observe the objects around him.<br />The most important point of the arrangement of the outdoor environment<br />is children get a unique experience. For example, the science that comes by<br />itself naturally, that explores and observes with theirown hands. Children can<br />see the color change, holding the bark of a tree, hear the crickets or smell the<br />air after it rains; the children use all their feelings to learn about their world.<br />Noting the importance of the outdoor environment to support the growth and<br />development of children then you should give serious consideration in the<br />design and use of the outdoor play area.</p>

THE EARLY CHILDHOOD'S EMOTIONAL INTELLIGENCE. This article examines the characteristics of clever early childhood and can control emotions, so that we are able to know how to train this golden generation to the maximum extent possible to have good emotional intelligence. Smart children may not be able to control their emotions, many occur smart children but have angry temper, difficult to control themselves, emotional outbursts. Sometimes the opposite is a child who is not smart but not emotional, can reduce anger, and can control himself. This research is a type of library research, data obtained from library sources in the form of research journals, research reports, textbooks, papers, scientific discussions, and so forth. Then the library materials are discussed critically and deeply. The characteristics of a person are said to have high emotional intelligence if he is socially stable, sociable and humorous. It's not easy to be afraid or nervous, able to adjust to the stress burden. It has a great ability to involve yourself with people or problems, to take responsibility and have a moral outlook. Their emotional life is rich, but reasonable, has a sense of comfort towards themselves, others and their environment

Hyperlipidemia is generally managed with statin-based drugs. Simvastatin serves as a 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGR) inhibitor, with prolonged use proven to cause side effects. In the present study, antihyperlipidemic material is tested for its effect in lowering lipid in animals and its proven ability to bind to HMGR. Hyperlipidemia rats were divided into four groups, with different doses of 0, 57, and 114 mg/kg BW of apple peel extract (APE) and simvastatin (3.6 mg/kg BW). The total cholesterol (TC), total triglyceride (TG), low-density lipoprotein cholesterol (LDLc), and high-density lipoprotein cholesterol (HDLc) serum were measured. In silico inhibition test of HMGR activity was conducted by molecular docking using PyRx software. This process places HMGR as a receptor and active compound of apple peels as a ligand. APE treatment with a dose of 114 mg/kg BW could significantly reduce LDLc and increase serum HDLc levels. Docking tests confirmed that quercetin, chlorogenic acid, epicatechin, and catechins depicted HMGR inhibition. Quercetin could bind to HMGR at a similar location to amino acid residues as simvastatin. These material extracts have inhibited cholesterol synthesis through a stronger HMGR inhibition than simvastatin.

Background and Aim: Hyperlipidemia is an important risk factor for cardiovascular disease. The use of statins has adverse side effects that result in oxidative stress disorders. The objective of this study was to investigate the antihyperlipidemic effect of a combination of Cinnamomum burmannii and Eleutherine palmifolia extract in high-fat diet (HFD)-induced hyperlipidemia mice. Materials and Methods: Mice were divided into eight groups (n=4): Control group or healthy mice (normal), HFD-induced hyperlipidemic mice without any treatment (CE0), HFD-induced hyperlipidemic mice treated with 3.6 mg/kg body weight (BW) atorvastatin (atorvastatin), and HFD-induced hyperlipidemic mice treated with a combination of C. burmannii and E. palmifolia in the following ratios: 300:0 (C300), 225:75 (C225), 150:150 (CE150), 75:225 (E225), and 0:300 (E300). Mice were fed a HFD for 4 months to induce hyperlipidemia. Total cholesterol, cholesterol oxidase-peroxidase aminophenazone (CHOD-PAP), triglyceride-glycerine, and fat serum were analyzed with colorimetric method. The measurement of superoxide dismutase was done with the xanthine oxidase method and malondialdehyde measurement was done with the thiobarbituric acid method. Results: Results showed an increase in antihyperlipidemic characteristics as the concentration of E. palmifolia extract (p<0.05) increased. Duncan's multiple range test also showed an increase in anti-stress oxidation as the concentration of C. burmannii extract (p<0.05) increased. Conclusion: The E225 group showed the most potential as a safe, antihyperlipidemic agent characterized by improvement in lipid profile and antioxidant balance.

The purpose of education in Indonesia is to form a complete Indonesian man. It entirely means that human development requires a balance between the cognitive, affective, psychomotor, and religious domains. Religion cannot be separated from the development of one's personality, because in essence man in the world is to live and worship God. Learning science is basically a digging, review, disclosure, understanding on research symptoms, structures, and functions of nature around which then brought into the classroom as learning activities with scientific rules that are commonly developed. This activity is not an independent activity, but it is a scientific activity associated with the belief in the greatness of the creator for the development of student character. Position of student character development is very important before the scientific education is done.This research was conducted for 1 semester by using sample of 49 students who took course of plant ecology. The purpose of this research is to understand the development of student character by studying nature based on Islamic religion. The research method was analyzed by RapRiCons with modification, and with multi-dimensional scaling (MDS) which was then followed by Monte Carlo analysis. The results showed that learning strategies by integrating religion and science showed a positive increase in student character.