Antihyperpigmentation Effect of The Combination of Turmeric (Curcuma domestica Val.) and Bitter Melon Leaves (Momordica Charantia L.)  Ethanol Extracts on Guinea Pig  Skin

Fithria, Risha Fillah; Anas, Yance; Safitri, Erika Indah

doi:10.22435/jki.v8i1.7727.10-16

Cited by 2 publications

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“…In guinea pig skin biopsy exposed to UVB radiation for 2 weeks, a significant reduction in hyperpigmentation was observed in objects that received topical application of a preparation containing extracts of turmeric (500-1000 µg/ml) and cucumber quail (Momordica charantia L.) -commonly referred to as bitter melon -throughout the study period. The observed effects were equivalent to or even superior to the use of a commercially available product comprising, among other things, hydroquinone -a tyrosinase inhibitor with known melanogenesis inhibiting efficacy [15]. In the aforementioned case reports of patients with photodamaged skin, regular use of curcumin gel led to a significant lightening of skin discolouration resulting from exposure to UV [13].…”

Section: Reduction Of Hyperpigmentationmentioning

confidence: 91%

Cosmetics containing turmeric in the light of the results of scientific research

Kryst

2023

Aesth Cosmetol Med

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In recent years, cosmetics containing substances of natural origin have become increasingly popular. Turmeric and the bioactive substances extracted from it, are the subjects of research not only in medicine but also to demonstrate the positive effects of turmeric on skin conditions. The study aimed to present the results of scientific research on the potential applications of turmeric and its isolates in dermocosmetics. Recents studies indicate that curcumin isolated from turmeric has strong antioxidant activity and skin photodamageminimising properties. Additionally, due to inhibition of enzymes responsible for the degradation of collagen and elastin in the skin, curcumin is expected to be used in formulations that reduce the signs of ageing. On the other hand, the antiinflammatory and antimicrobial effects of active substances extracted from turmeric can be applied in preparations intended for acne-prone skin. It is also important that the ingredients of the cosmetic preparation provide stability to the active substances extracted from turmeric and increase their penetration into the deeper layers of the skin.

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Section: Reduction Of Hyperpigmentationmentioning

confidence: 91%

Cosmetics containing turmeric in the light of the results of scientific research

Kryst

2023

Aesth Cosmetol Med

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“…Kojic acid can be used at a concentration of 1%-4% singly or in combination with other agents. Kojic acid when used alone is less effective than hydroquinone 2% [1].…”

Section: Introductionmentioning

confidence: 92%

“…Hyperpigmentation is still a serious problem for Indonesian women. There are many things that trigger hyperpigmentation, including exposure to ultraviolet (UV) light, can make the tyrosinase enzyme overwork to convert L-3,4-dihydroxyphenylalanine (L-DOPA) to dopachrome, which eventually turns into melanin [1].…”

Section: Introductionmentioning

confidence: 99%

Anti-Tyrosinase Activity From Various Solvents of Peanut Shell (Arachis Hypogaea L.) Extracts in Vitro

Fithria¹,

Krisdiana²,

Muslimah³

et al. 2019

Int J App Pharm

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Objective: This study aimed to determine in vitro anti-tyrosinase activity from various solvents of peanut shell extracts and to find out if the activityis better than kojic acid which is a conventional compound used as anti-hyperpigmentation agent.Methods: Extraction was done by maceration method with various solvents of ethyl acetate, n-hexane, and 70% ethanol. Extracts were made into theseries concentration of 25, 50, and 75 μg/ml. Kojic acid with concentration of 50 μg/ml used as positive control and 5% dimethyl sulfoxide used asnegative control. Tyrosinase enzyme will react with L-3,4-dihydroxyphenylalanine substrate to produce dopachrome compound. The absorbance ofdopachrome read by microplate reader at λ = 492 nm. If the absorbance read by the microplate reader is low, means that the inhibition power of thepeanut shell extract against the tyrosinase enzyme is high. Anti-tyrosinase activity seen by the percentage inhibition value. The percentage inhibitionvalue was analyzed with Kruskal–Wallis test followed by Mann–Whitney U-test; all tests were carried out with a confidence level of 95%.Results: The mean of percentage inhibition value of n-hexane extract ranged from 12.44 ± 1.66% to 39.82 ± 1.33%, 70% of ethanol extract rangedfrom 39.98 ± 0.85% to 70.19 ± 1.98%, and ethyl acetate extract ranged from 17.85 ± 0.78% to 60.30 ± 0.97%. Kojic acid has mean percentageinhibition value of 78.19 ± 1.97%. IC50 of ethanol, ethyl acetate, and n-hexane extracts was, respectively, 40.53 μg/ml, 63.49 μg/ml, and 91.95 μg/ml.Ethanol extract contains flavonoid, tannin, and saponin. Ethyl acetate extract contains flavonoid.Conclusion: All various solvents of peanut shell extracts have anti-tyrosinase activity but not better than kojic acid. Ethanol extract with concentrationof 75 μg/ml has the greatest anti-tyrosinase activity.

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Antihyperpigmentation Effect of The Combination of Turmeric (Curcuma domestica Val.) and Bitter Melon Leaves (Momordica Charantia L.) Ethanol Extracts on Guinea Pig Skin

Cited by 2 publications

References 0 publications

Cosmetics containing turmeric in the light of the results of scientific research

Cosmetics containing turmeric in the light of the results of scientific research

Anti-Tyrosinase Activity From Various Solvents of Peanut Shell (Arachis Hypogaea L.) Extracts in Vitro

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