Antihypertension Study of Anredera Cordifolia (Ten). V. Steenis Extract and Its Fractions in Rats Through Dexamethasone Induction and Nitric Oxide Release.

Garmana, Afrillia Nuryanti; Sukandar, Elin Yulinah; Fidrianny, Irda

doi:10.22159/ajpcr.2017.v11i1.22312

Cited by 8 publications

(8 citation statements)

References 12 publications

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“…DEX is sometimes illegally used with other doping agents and anabolic in livestock to make animals grow faster by increasing meat protein levels while decreasing lipid levels [10]. It is classified as a long-acting corticosteroid [41,45].…”

Section: Discussionmentioning

confidence: 99%

The Combined Effect of Dexamethasone and Bacillus Calmette–guérin on the Neurobehavioral Aspect in Male Mice (Mus Musculus)

Haouli

Djemli

Tahraoui

2019

Asian J Pharm Clin Res

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Objective: Our study aims to evaluate the combined effect of Bacille Calmette–Guérin (BCG) and dexamethasone (DEX) on male mice undergoing behavioral testing (forced swimming test, elevated plus maze, tail suspension test, and sucrose intake). An intraperitoneal injection of 0.2 ml/mg of BCG and 0.1 ml/mg of DEX body weight was administered after all behavioral tests were applied. Methods: This study is based on the distribution of 15 male mice in three groups: Controls, DEX, and DEX+BCG. These mice underwent behavioral tests. Results: The result after administration of DEX and BCG was found after 10 days. We observed an increase in locomotors activity with some degree of anxiety. Conclusion: This allowed us to conclude that the combination of DEX+BCG seems to play a depressinogenic effect that will develop to become antidepressive.

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Section: Discussionmentioning

confidence: 99%

The Combined Effect of Dexamethasone and Bacillus Calmette–guérin on the Neurobehavioral Aspect in Male Mice (Mus Musculus)

Haouli

Djemli

Tahraoui

2019

Asian J Pharm Clin Res

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“…On day 28, serum was obtained to determine the impact of treatment on NO levels. The Griess method was used to calculate the NO level in serum (Garmana et al, 2018). Increased NO concentrations suggest a vasodilator effect, which results in a decrease in pressure.…”

Section: No Serum Level Measurementmentioning

confidence: 99%

Effect of Curcuma longa L. extract on noninvasive cardiovascular biomarkers in hypertension animal models

Hasimun¹,

Suprijono²,

Hidayatullah³

et al. 2021

J Appl Pharm Sci

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Arterial stiffness and QRS-T angle (the spatial angle between the vectors of the T-wave and QRS loops on typical electrocardiogram) are essential biomarkers for estimating the risk of cardiovascular events in hypertensive patients. Turmeric or Curcuma longa L., which belongs to the Zingiberaceae family, is reported to have antihypertensive activity. However, its effect on these biomarkers is unknown. This research investigates the antihypertensive effect of turmeric extract on arterial stiffness and frontal plane QRS-T angle in hypertensive animal models. High blood pressure was induced by a high-fat and high-fructose (HFHF) diet for 28 days in male Wistar rats. A daily dose of turmeric extract (50, 100, and 200 mg/kg) or captopril was administered to hypertensive animals for 14 days. Blood pressure, arterial stiffness, heart rate (HR), QRS-T angle, and nitric oxide (NO) levels were evaluated. An HFHF diet triggers a decrease in NO serum levels resulting in significantly increased arterial stiffness, which correlates with increased systolic blood pressure and diastolic blood pressure due to ventricular dysfunction supported by the wide QRS-T angle, and also increased HR. Turmeric extract significantly enhances the bioavailability of NO vasodilators, effectively reversing all the hypertensive-induced changes studied. This extract is helpful as a vasodilator that lowers blood pressure by repairing arterial stiffness and preventing ventricular dysfunction of the heart.

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“…Nitric oxide serum levels were measured by previously reported methods with a slight modification (Garmana et al, 2018). On the 28th day, blood was drawn from all groups of animals.…”

Section: Animals Protocolmentioning

confidence: 99%

Influences of Centella Asiatica and Curcuma Longa on Arterial Stiffness in a Hypertensive Animal Model

2021

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There is a strong relationship between arterial stiffness and high blood pressure. Arterial stiffness increases the risk of a cardiovascular event and sudden death, especially in hypertensive patients. This study aimed to determine the effective combination of Centella asiatica and Curcuma longa on arterial stiffness in hypertensive animal models. Twenty-five male rats aged 2-3 months were randomly into five groups. The groups comprising the negative control and positive control group (receiving drug carriers), the test drug group receiving captopril 2.5 mg/kg, the combination of Centella asiatica (CA) and Curcuma longa (CL) doses of 50 and 100 mg/kg. Except for the control group, all groups received a high-fat diet and 25% fructose drinking water for 28 days. On day 15, they received test medicines. On days 0, 14, and 28, systolic and diastolic blood pressures, as well as the PWV (pulse wave velocity), were assessed. Nitric oxide levels in serum were measured using Griess reagents on day 28. The results showed that a combination of CA and CL doses of 50 and 100 mg/kg reduced systolic and diastolic blood pressure accompanied by a decrease in PWV and a statistically significant increase in serum NO levels (p <0.05). It concluded that a combination of CA and CL has the potential as antihypertensive, improving arterial elasticity.

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Antihypertension Study of Anredera Cordifolia (Ten). V. Steenis Extract and Its Fractions in Rats Through Dexamethasone Induction and Nitric Oxide Release.

Cited by 8 publications

References 12 publications

The Combined Effect of Dexamethasone and Bacillus Calmette–guérin on the Neurobehavioral Aspect in Male Mice (Mus Musculus)

The Combined Effect of Dexamethasone and Bacillus Calmette–guérin on the Neurobehavioral Aspect in Male Mice (Mus Musculus)

Effect of Curcuma longa L. extract on noninvasive cardiovascular biomarkers in hypertension animal models

Influences of Centella Asiatica and Curcuma Longa on Arterial Stiffness in a Hypertensive Animal Model

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