Antihypertensive activity of ethanol extract combination of Anredera cordifolia (Ten.) v. Steenis and Sonchus arvensis L. leaves on angiotensin II- induced male wistar rat

Sukandar, Elin Yulinah; Garmana, Afrillia Nuryanti; Aidasari, Anggi Utri; Crystalia, Audrey Amira

doi:10.35333/jrp.2019.73

Cited by 3 publications

(2 citation statements)

References 6 publications

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“…[ 6 ] The combination of A. cordifolia and S. arvensis has been reported to lower systolic and diastolic blood pressure better than a single extract in the ACE inhibitor mechanism. [ 15 ]…”

Section: Discussionmentioning

confidence: 99%

Antihypertensive Activity of Combination of Anredera cordifolia (Ten.) V. Steenis and Sonchus arvensis L. Leaves on Epinephrine Induced Male Wistar Rat

Suliska

Suryani

Insanu

et al. 2021

Journal of Advanced Pharmaceutical Technology &Amp; Research

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In Indonesia, hypertension is a condition that can lead to death through stroke and TB. Herbs have traditionally been used in Indonesia as an alternative medicine for lowering blood pressure. The leaves of Anredera cordifolia and Sonchus arvensis have been investigated for their antihypertensive potential. Based on the number of treatments, rats were randomized into groups. Each group consists of five rats. The test animals were grouping as follows: the positive control group (hypertension induction without treatment), A. cordifolia 50 mg/kg b.w. group, A. cordifolia 100 mg/kg b.w., S. arvensis 50 mg/kg b.w, S. arvensis 100 mg/kg b.w., A. cordifolia 25 mg/kg b.w + S. arvensis 25 mg/kg b.w, A. cordifolia 50 mg/kg b.w + S. arvensis 50 mg/kg b.w, and atenolol 4.5 mg/kg b.w. The rats were given 0.25 mg/kg b.w. of epinephrine intraperitoneally. The initial, after induction, and final blood pressure of the animals were measured using the CODA ® noninvasive blood pressure device. All animal test groups at T60 showed a significant difference in systolic and diastolic blood pressures to initial blood pressure (T0), P < 0.05. The combination of A. cordifolia 50 mg/kg b.w and S. arvensis 50 mg/kg b.w showed the highest percent inhibition of systolic and diastolic blood pressure. The combination of A. cordifolia and S. arvensis 50–50 mg/kg b.w showed the best effect of lowering systolic and diastolic blood pressure on the pathway of inhibiting adrenergic receptors.

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“…[ 6 ] The combination of A. cordifolia and S. arvensis has been reported to lower systolic and diastolic blood pressure better than a single extract in the ACE inhibitor mechanism. [ 15 ]…”

Section: Discussionmentioning

confidence: 99%

Antihypertensive Activity of Combination of Anredera cordifolia (Ten.) V. Steenis and Sonchus arvensis L. Leaves on Epinephrine Induced Male Wistar Rat

Suliska

Suryani

Insanu

et al. 2021

Journal of Advanced Pharmaceutical Technology &Amp; Research

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show abstract

“…The ethanolic extract of S. arvensis and A. cordifolia in combination has been shown to have an antihypertensive effect by inhibiting ACE activity [19]. Meanwhile, the water extract of S. arvensis and A. cordifolia as a combination in a 1:1 ratio at a dose of 100 mg/kg body weight showed an effect to lower systolic and diastolic blood pressure by inhibiting adrenergic receptors [5], so it may be an additional option to treat hypertension in pregnant women.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the teratogenic effect of water extract of Sonchus arvensis L. and Anredera cordifolia (Ten.) Steenis leaves as a combination in Wistar rat

SULISKA¹,

MENTARI²,

SUKANDAR³

2023

jrp

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Water extract of Sonchus arvensis and Anredera cordifolia leaves as a combination has been proven for their antihypertensive activity, but there is no information about its safety for pregnant women yet. This experiment aimed to evaluate the teratogenic effect of water extract of S. arvensis and A. cordifolia leaves as a combination (1:1) at doses of 100 mg/kg bw, 400 mg/kg bw, and 1000 mg/kg bw in Wistar rats. The extract was made into suspension in sodium carboxymethyl cellulose (Na-CMC) 0.5% and given orally to pregnant rats on gestation day 6-15 as much as 1 mL/100 gram bw. Pregnant rats were sacrificed at gestation day 19. All parameters related to fetuses included the number of fetuses, fetal weight, skeletal and organ malformation were evaluated. The percentage of skeletal and organ malformation of each treatment groups was compared to the control group and analyzed with one-way ANOVA method using IBM SPSS 28. There was no significant difference in both average number and fetal weight from all treatment groups compared to the control group (P>0.05). Skeletal malformation was not found, but there were undeveloped fetuses (resorption) and some fetuses with small brains in all groups. The percentage of each treatment groups for those two conditions was not significantly different compared to the control group. Therefore, water extract of S. arvensis and A. cordifolia leaves as a combination at doses of 100 mg/kg bw, 400 mg/kg bw, and 1000 mg/kg bw contraindicated for pregnant women and those who are planning on pregnancy.

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Potential Therapeutic use of Anredera cordifolia in Chronic Non-Communicable Diseases: A Scoping Review

Trombini,

Heisler,

Corcini

et al. 2024

Aquichan

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Introduction: Anredera cordifolia is a plant recognized as a non-conventional food plant. In folk medicine, it shows promise, being used in the treatment of skin diseases, diabetes, and hypertension. Objectives: to map the properties of the Anredera cordifolia plant in the therapeutic process of non-communicable chronic diseases. Materials and methods: The study was based on the Joanna Briggs Institute guidelines. The search was conducted in the Medline/PubMed, Scopus, Web of Science, and CINAHL databases in 2022 and updated in 2023. Selection criteria were primary studies, in any language, country of origin, and publication year, conducted with humans, animals, and/or cellular models, in a laboratory context, focusing on the properties of the plant. Selection was performed independently by two reviewers using the Rayyan software. Data were analyzed using content analysis. Results: In the 27 included articles, the results demonstrated that the plant has positive properties in the treatment of diabetes mellitus, arterial hypertension, chronic kidney disease, obesity, and cataracts, as well as being beneficial in controlling cholesterol, triglyceride, and uric acid levels. The main therapeutic properties identified were hypoglycemic effect and reduction in serum levels of triglycerides and total cholesterol. The plant also showed beneficial effects on the healing of diabetic wounds, reduction in heart rate, and obesity. Conclusions: Chronic diseases with evidence on the use of the plant include hypertension, diabetes, kidney disease, obesity, and cataracts. Additionally, the plant has beneficial properties regarding clinical markers such as triglycerides, cholesterol, and blood glucose.

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Antihypertensive activity of ethanol extract combination of Anredera cordifolia (Ten.) v. Steenis and Sonchus arvensis L. leaves on angiotensin II- induced male wistar rat

Cited by 3 publications

References 6 publications

Antihypertensive Activity of Combination of Anredera cordifolia (Ten.) V. Steenis and Sonchus arvensis L. Leaves on Epinephrine Induced Male Wistar Rat

Antihypertensive Activity of Combination of Anredera cordifolia (Ten.) V. Steenis and Sonchus arvensis L. Leaves on Epinephrine Induced Male Wistar Rat

Evaluation of the teratogenic effect of water extract of Sonchus arvensis L. and Anredera cordifolia (Ten.) Steenis leaves as a combination in Wistar rat

Potential Therapeutic use of Anredera cordifolia in Chronic Non-Communicable Diseases: A Scoping Review

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