Antihypertensive effect of carvacrol is improved after incorporation in β‐cyclodextrin as a drug delivery system

Abstract

Hypertension is a major public health concern globally and a risk factor for cardiovascular diseases (CVD). 1 The number of hypertensive adults increased from 594 million in 1975 to 1.13 billion in 2015, mainly in low-income and middle-income countries. 2 Moreover, in Brazil, approximately one quarter of the adult population are reported to have hypertension. 3 Globally, CVD was responsible for approximately 17.5 million deaths in 2012. If current trends continue, the annual number of deaths will increase to 22.2 million by 2030. 4 Frequently, hypertension is associated with metabolic disorders, functional or structural alterations of target organs, which are aggravated by behavioural risk factors, such as smoking, obesity, excessive salt intake and aging. The most common form of hypertension is "essential hypertension"; however, the causes remain unknown. 5,6 The treatment of hypertension includes some classes of drugs, including: beta-blockers, diuretics, angiotensin-converting enzyme inhibitors, angiotensin II receptor blockers, calcium channel

Alpha-Lipoic Acid as an Antioxidant Strategy for Managing Neuropathic Pain

“…The most used Cooperative Patent Classification (CPC) codes ( Figure 3 ) are for the treatment of diseases affecting the nervous system, as expected from the used keywords, but also cardiovascular diseases, which can be due to the association between cardiovascular diseases and the inflammatory response [ 101 ]. Most patents focus on combining ALA with other drugs in pharmaceutical preparations.…”

Polymeric Carriers Designed for Encapsulation of Essential Oils with Biological Activity

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Role of Terpenophenolics in Modulating Inflammation and Apoptosis in Cardiovascular Diseases: A Review

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