Hypertension is a major public health concern globally and a risk factor for cardiovascular diseases (CVD). 1 The number of hypertensive adults increased from 594 million in 1975 to 1.13 billion in 2015, mainly in low-income and middle-income countries. 2 Moreover, in Brazil, approximately one quarter of the adult population are reported to have hypertension. 3 Globally, CVD was responsible for approximately 17.5 million deaths in 2012. If current trends continue, the annual number of deaths will increase to 22.2 million by 2030. 4 Frequently, hypertension is associated with metabolic disorders, functional or structural alterations of target organs, which are aggravated by behavioural risk factors, such as smoking, obesity, excessive salt intake and aging. The most common form of hypertension is "essential hypertension"; however, the causes remain unknown. 5,6 The treatment of hypertension includes some classes of drugs, including: beta-blockers, diuretics, angiotensin-converting enzyme inhibitors, angiotensin II receptor blockers, calcium channel
<div><strong>Introdução</strong>: O Linalol é um metabólito secundário, componente de óleos essenciais aromáticos de origem vegetal, sendo uma das substâncias mais importantes na indústria farmacêutica; é utilizado como fixador de fragrâncias, mas também pela medicina popular para efeitos anti-inflamatórios, analgésicos, hipotensores, vasorrelaxantes, antinociceptivos e atividade antimicrobiana. Além dessas propriedades, tem ações hipnóticas, hipotérmicas e sedativas. <strong>Objetivo</strong>: Sistematizar o conhecimento acerca dos efeitos biológicos já conhecidos do Linalol e apresentar as futuras possibilidades para este monoterpeno. <strong>Metodologia</strong>: A revisão sistemática da literatura conta com artigos publicados no período de 2001 a 2014, cuja busca foi realizada no primeiro semestre de 2014, a partir das palavras-chave e seus respectivos correlatos nos idiomas inglês e espanhol, nas bases de dados on-line PUBMED, MEDLINE e LILACS. Incluíram-se artigos que abordavam o uso de Linalol para diferentes fins. Houve ainda a inclusão de teses e dissertações que atendessem aos critérios de inclusão. Quanto aos excluídos, contam-se aqueles encontrados em duplicidade e os encontrados além do período de publicação estipulado. <strong>Resultado</strong>: Encontrou-se um total de 2.734 artigos relacionados à palavra-chave Linalol nos diferentes idiomas. A partir da leitura dos resumos e aplicação dos critérios de exclusão, selecionaram-se 37 artigos para discussão. <strong>Conclusão</strong>: O Linalol cria uma nova possibilidade terapêutica em diversas enfermidades, quando aplicado a órgãos e tecidos diferenciados. Poderá ser forte aliado do sistema cardiovascular, na redução e controle da pressão arterial, ainda tão difícil de ser alcançado, no controle da dor, seja crônica, inflamatória ou neuropática, e resultados recentes mostram o grande potencial do Linalol para uso na terapia anticâncer. Assim sendo, é necessária a realização de outros trabalhos, na intenção de melhor esclarecer os mecanismos e ações já conhecidos e buscar novas</div><div>aplicações para este material.</div>
Introduction: Knowledge of Brazilian scientists profile is important to understand the factors that influence the behavior of those interested in developing science. Objective: To outline the profile of Brazilian physiotherapist researchers, permanent, or collaborator professors of PhD programs in physiotherapy. Methods: Study of documentary analysis with scientometric techniques on physiotherapist data in Brazilian doctors associated professors in PhD programs. To identify the professors, the Sucupira and Lattes Platforms were used, and the research areas were categorized according to COFFITO. Data on the research area, the number of orientations, publications and impact factor average (JCR) were analyzed by 1-way ANOVA test (p < 0.05), and a collaboration network was built using Gephi 0.9.1 software. Results: Nine institutions of higher education in Brazil have a PhD in physiotherapy. A total of 119 professors are associated with UFMG (20.2%), UFSCAR (17.6%), UFRN (13.4%), and UNINOVE (10.9%). The median number of doctors graduated by the professors was 1.0 (0.0 -6.0) and in publications in the period was 4.6 (2.4 -8.4). The main study designs were observational 71 (59.7%), and the main research area was neurofunctional 25 (21.0%). The collaboration between UFSCAR and UFMG professors is strengthened. Conclusion: There are few specific doctoral programs for physiotherapists in Brazil. The majority of them are concentrated in the southeast region, and the professor staff have very heterogeneous characteristics related to the duration of the programs, the nature of the institution, or the affiliation of the professor.
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