Itaconimides derivatives induce relaxation in mesenteric artery and negative inotropism by inhibition of CA2+ influx

7-Hydroxycoumarin Induces Vasorelaxation in Animals with Essential Hypertension: Focus on Potassium Channels and Intracellular Ca2+ Mobilization

“…Vascular smooth muscle cells (VSMCs) are exposed to mechanical stress and the pressure of blood flow, and play an important role in maintaining vascular tone and resistance [ 21 ]. In addition, the endothelium regulates vascular tone by synthesizing and releasing an array of endothelium-derived relaxing factors, such as nitric oxide and endothelium-dependent hyperpolarization factors, as well as endothelium-derived contracting factors [ 22 , 23 ]. In the current study, when the endothelium of mesenteric artery rings was removed, the vasorelaxant effect of 7-HC was not significantly impaired, indicating that the vasorelaxant activity of 7-HC does not rely on the integrity of the endothelial layer.…”

Ru(ii) based dual nitric oxide donors: electrochemical and photochemical reactivities and vasorelaxant effect with no cytotoxicity

“…The superior mesenteric arteries were quickly removed as described by Moraes and colleagues. 62 Briefly, the superior mesenteric artery was removed and cleaned from connective tissue and fat, and segmentally cut into rings (2 mm), which were suspended in organ baths containing Tyrode's solution, bubbled with 95% O 2 /5% CO 2 , and maintained at 37 °C and pH 7.4. Tissues were stabilized with an optimal resting tension of 0.75 g for 60 min.…”