Antihypertensive effect of passion fruit peel extract and its major bioactive components following acute supplementation in spontaneously hypertensive rats

Lewis, Brandon; Herrlinger, Kelli A.; Craig, Teresa; Mehring-Franklin, Cynthia E.; DeFREITAS, Z.; Hinojosa‐Laborde, Carmen

doi:10.1016/j.jnutbio.2012.11.003

Cited by 37 publications

(32 citation statements)

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“…Em geral, o teor de polifenóis neste tipo de subproduto mostrase superior ao encontrado na porção comestível ou polpa dos frutos (TEHRANIFAR et al, 2011), possivelmente porque os polifenóis são metabólitos secundários dos vegetais, os quais estão geralmente envolvidos na defesa contra a radiação ultravioleta ou a agressão por agentes patogênicos. Aos compostos fenólicos encontrados na casca do maracujá, têm sido atribuídos efeitos anti-infl amatório (ZERAIK et al, 2011;ZERAIK et al, 2012) e anti-hipertensivo (LEWIS et al, 2013). Os compostos fenólicos vitexina, isovitexina, isoorientina e apigenina, previamente encontrados na casca do maracujá de distintas espécies (ZERAIK et al, 2012 Tabela 2 -Avaliação da atividade antioxidante e do teor de compostos fenólicos totais da farinha obtida da casca do maracujá Passiflora edulis.…”

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Capacidade antioxidante e composição química da casca de maracujá (Passiflora edulis)

et al. 2014

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Section: Resultsunclassified

Capacidade antioxidante e composição química da casca de maracujá (Passiflora edulis)

et al. 2014

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“…DL-Phenylalanine on the other hand has been reported to slightly reduce blood pressure in humans [82]. Passiflora incarnata is antihypertensive in spontaneously hypertensive rats [83] and 5-Hydroxytryptophan reduced blood pressure in hypertensive patients [84]. …”

Section: Discussionmentioning

confidence: 99%

Enhanced functional connectivity and volume between cognitive and reward centers of naïve rodent brain produced by pro-dopaminergic agent KB220Z

et al. 2017

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Dopaminergic reward dysfunction in addictive behaviors is well supported in the literature. There is evidence that alterations in synchronous neural activity between brain regions subserving reward and various cognitive functions may significantly contribute to substance-related disorders. This study presents the first evidence showing that a pro-dopaminergic nutraceutical (KB220Z) significantly enhances, above placebo, functional connectivity between reward and cognitive brain areas in the rat. These include the nucleus accumbens, anterior cingulate gyrus, anterior thalamic nuclei, hippocampus, prelimbic and infralimbic loci. Significant functional connectivity, increased brain connectivity volume recruitment (potentially neuroplasticity), and dopaminergic functionality were found across the brain reward circuitry. Increases in functional connectivity were specific to these regions and were not broadly distributed across the brain. While these initial findings have been observed in drug naïve rodents, this robust, yet selective response implies clinical relevance for addicted individuals at risk for relapse, who show reductions in functional connectivity after protracted withdrawal. Future studies will evaluate KB220Z in animal models of addiction.

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“…The antihypertensive properties of passion fruit were previously reported in preclinical studies performed in SHR rats. A study supplemented the rats with the passion fruit flesh for five days to give hypotensive effect, and the effect attributed to the increased antioxidant activity in animals, since the pulp of the fruit is rich in phenolic compounds, ascorbic acid, carotenoids and flavonoids [21,22].…”

Section: Discussionmentioning

confidence: 99%

Effects of the single supplementation and multiple doses of Passiflora incarnata L. on human anxiety: A Clinical Trial, Double-blind, Placebo-controlled, Randomized

Silva¹,

Costa²,

Alves³

et al. 2017

int arch med

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Object: This study aimed to investigate the effects of Passiflora incarnata L. on anxiety in humans. Method:The individuals were randomly assigned to one of the following groups: Placebo or experimental, n =30, single dose, as well as Placebo or Experimental, n =15, multiple dose. The experimental human anxiety was induced by simulated public speaking test in the following phases: Basal (B), stressful (A), speech 1 (S1), speech 2 (S2) and Final (F). We evaluated the Systolic Blood Pressure (SBP), and Diastolic (DBP), Heart Rate (HR), Electrical Conductance of Skin and extremities temperature (ET) and filled The state-trait anxiety inventory (STAI S e T).Results: During the single dose, the HR was reduced at the end of the speech (86±2.0 to 74±3.0 bpm) the experimental group compared to the placebo group (p<0.05); the STAI-S did not change. In the delineation of multiple doses, SBP was reduced, in mmHg, in the experimental group compared to the placebo group during all phases. Experimental: 106±1.0 (B), 111±1.0 (A), 121±2.0 (S1), 115±3 (S2), 104±2.0 (F) IntroductionAnxiety disorders reach over 25% prevalence, including the fear of public speaking [1]. Anxiety comprises emotional and behavioral factors through fear manifestation, insecurity, apprehensive anticipation, catastrophic thinking, increase in wakefulness or alert period and physiological, as activation of the hypothalamic-pituitary-adrenal (HPA) axis, leading neurovegetative symptoms such as insomnia, tachycardia, pallor, increased perspiration, muscle tension, trembling, dizziness, intestinal disorders, among others [2].The impact of anxiety on the individuals's health covers changes in blood pressure, heart rate and an increased risk of cardiovascular diseases such as coronary heart disease (risk tripled) and cerebrovascular [3].Therefore, researchers have invested in as natural forms taken to treat or ameliorate the symptoms of anxiety, such as the use of herbs. Plants that are most studied with anxiolytic potential are Kawa, the St. John's Wort and Passiflora spp. [4][5][6][7]. The Passiflora extract has been used in many researches, presenting in their chemical constitution polyphenols, polyunsaturated fatty acids, fiber and other substances, such as passiflorin, one indole alkaloid, being the last one associated with anxiolytic effects [3].The effects of Passiflora incarnata L on anxiety was previously assessed in animals [8,4] and in humans [9-10] with satisfactory results [7]. Epidemiological studies have shown that the fear of public speaking is one of the biggest phobias that affect people, being highly prevalent among students [11].The study proposal was to evaluate symptoms of anxiety of public speaking, under a single dose and multiple doses through the simulated public speaking (SPS) test through the intervention with the encapsulated dry extract of the whole plant Passiflora incarnata L. Materials and MethodsSubjects A study population consisted of university students, adults, healthy, between 24 and 31 years, of both sexes, wer...

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Antihypertensive effect of passion fruit peel extract and its major bioactive components following acute supplementation in spontaneously hypertensive rats

Cited by 37 publications

References 20 publications

Capacidade antioxidante e composição química da casca de maracujá (Passiflora edulis)

Capacidade antioxidante e composição química da casca de maracujá (Passiflora edulis)

Enhanced functional connectivity and volume between cognitive and reward centers of naïve rodent brain produced by pro-dopaminergic agent KB220Z

Effects of the single supplementation and multiple doses of Passiflora incarnata L. on human anxiety: A Clinical Trial, Double-blind, Placebo-controlled, Randomized

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