Enhanced functional connectivity and volume between cognitive and reward centers of naïve rodent brain produced by pro-dopaminergic agent KB220Z

Abstract

Dopaminergic reward dysfunction in addictive behaviors is well supported in the literature. There is evidence that alterations in synchronous neural activity between brain regions subserving reward and various cognitive functions may significantly contribute to substance-related disorders. This study presents the first evidence showing that a pro-dopaminergic nutraceutical (KB220Z) significantly enhances, above placebo, functional connectivity between reward and cognitive brain areas in the rat. These include the nucleus accumbens, anterior cingulate gyrus, anterior thalamic nuclei, hippocampus, prelimbic and infralimbic loci. Significant functional connectivity, increased brain connectivity volume recruitment (potentially neuroplasticity), and dopaminergic functionality were found across the brain reward circuitry. Increases in functional connectivity were specific to these regions and were not broadly distributed across the brain. While these initial findings have been observed in drug naïve rodents, this robust, yet selective response implies clinical relevance for addicted individuals at risk for relapse, who show reductions in functional connectivity after protracted withdrawal. Future studies will evaluate KB220Z in animal models of addiction.

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“…The “ Reward Deficiency Syndrome Solution System” provided evidence for the feasibility of its adoption [ 19 , 20 ]. While the RDSQ and GARS are in development and should be launched in 2018, the patented foundational ingredients of the KB220/Z/ZBR formulas have been studied in both animal (see Figure 2 ) [ 21 ] and human research (see Figure 3 ) [ 22 ]. After 50 years of study of brain reward systems, we now have fMRI evidence that KB220/Z/ZBR variants can enhance resting state, functional connectivity and brain connectivity volume (recruit neuronal firing in the reward center of the brain) [ 21 ] and balance the brain reward circuitry, especially, in abstinent heroin-dependent people.…”

Reward Deficiency Syndrome Solution Focused Brief Therapy to Begin Integrating the Sciences of Addiction & Reward Deficiency Syndrome (RDS)

“…Neurological dysfunction must be treated with neurological solutions [59]. Psycho-education of Reward Deficiency Syndrome (RDS) and Reward Deficiency System Solutions (RDSS) [12,60] should be made available to the addiction-recovery treatment industry, to practitioners, counselors, therapists for continuing educational units (CEU), to facilitate the delivery and integration of new perspective and new solutions [61,62].…”

Pro-Dopamine Regulator - (KB220) to Balance Brain Reward Circuitry in Reward Deficiency Syndrome (RDS)

“…These areas include the nucleus accumbens, the cingulate gyrus, anterior thalamic nuclei, hippocampus and also prelimbic and infralimbic loci. Also, evidence for the restoration of resting state functional connectivity was seen as increased neuronal firing, measured by increased connectivity volume [ 67 ].…”

“…This summary of the research results provides substantial scientific support for the use of KB220 formulations based on almost 40 years of research. Indeed, we have recently demonstrated increased resting state functional connectivity and induction of physiological changes in the brain (neuroplasticity) [ 67 ].…”