Antihypertensive Effects and Endothelial Progenitor Cell Activation by Intake of Chicken Collagen Hydrolysate in Pre- and Mild-Hypertension

Saiga-Egusa, Ai; Iwai, Koji; Hayakawa, Tõru; Takahata, Yoshihisa; Morimatsu, Fumiki

doi:10.1271/bbb.80189

Cited by 33 publications

(16 citation statements)

References 13 publications

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“…These findings suggest that CCH supplementation may contribute in the prevention of atherosclerosis due to its anti‐inflammatory effects. CCH has been found to have significant ACE‐inhibitory and antihypertensive effects in spontaneously hypertensive rats 58; also an antihypertensive effect in mildly hypertensive humans 59. More in vivo studies are needed to determine the potential of CCH in prevention of atherosclerosis; however Zhang et al 60 demonstrated that CCH treatment in a cardiovascular damage rat model significantly reduced BP and concentrations of ICAM‐1, while increasing NO concentration.…”

Section: Addressing the Problem With Dietary Preventative Methodsmentioning

confidence: 99%

Role of dietary proteins and peptides in cardiovascular disease

Cam

Mejía

2011

Molecular Nutrition Food Res

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Cardiovascular disease (CVD) is the leading cause of death for both men and women in the United States and most other countries. Therefore, a disease of such wide-ranging impact calls for the development of multiple viable strategies for prevention. Diet plays an important role in the development of the major risk factors of CVD such as low-grade systemic inflammation, hypertension, obesity, diabetes and atherosclerosis, the most significant. Thus, diet-based methods of prevention would not only be more feasible, but ultimately more cost-effective than relying on drugs to combat this condition. In recent years, peptides derived from either animal or plant sources have been found to have various bioactive properties. Nevertheless, their potential impact on inflammation and prevention of atherosclerosis has not been fully explored, particularly at the molecular level. In this review, the most current scientific information from in vitro, in vivo and clinical studies on the role of dietary proteins and peptides on CVD has been summarized and discussed.

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Section: Addressing the Problem With Dietary Preventative Methodsmentioning

confidence: 99%

Role of dietary proteins and peptides in cardiovascular disease

Cam

Mejía

2011

Molecular Nutrition Food Res

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“…Compared with other foods, a distinguishing feature of collagen hydrolysates is that reported effects are not limited to a specific part of the body. Various effects have been reported, including improvement of joint pain, 1) increases in bone density, 2,3) reduction in blood pressure, 4) increases in water content in the stratum corneum, 5,6) and vascular protection. 7) Collagen is a protein found in the connective tissue such as the skin, bones, cartilages, and tendons, and accounts for approximately 30% of the total protein in the body.…”

mentioning

confidence: 99%

Absorption and Urinary Excretion of Peptides after Collagen Tripeptide Ingestion in Humans

Yamamoto

Deguchi

Onuma

et al. 2016

Biological & Pharmaceutical Bulletin

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Collagen tripeptide (CTP) is a collagen hydrolysate containing a high concentration of tripeptides with aGly-X-Y sequence, such as Gly-Pro-Hyp. To test the effects of this preparation, we compared the absorption of peptides in humans after ingestion of a tripeptide fraction of CTP (CTP-100), a CTP preparation containing ca. 50% Gly-X-Y tripeptides (CTP-50), and a collagen peptide that did not contain tripeptides (CP). The postprandial levels of Gly-Pro-Hyp and Pro-Hyp in the plasma increased in those subjects who ingested CTP-100 and CTP-50, and were higher with greater Gly-Pro-Hyp ingestion. This demonstrated that collagen hydrolysates were efficiently absorbed when the collagen was ingested in the tripeptide form. Gly-Pro-Hyp and Pro-Hyp were also found in the urine after ingestion of CTP-100 or CTP-50. Similar to the results for the plasma concentration, the urinary excretion of Gly-Pro-Hyp and Pro-Hyp was also dependent on the amount of Gly-Pro-Hyp ingested. This indicates that ingested Gly-Pro-Hyp and generated Pro-Hyp were relatively stable in the body and were transported to the urine in the peptide form. The concentration of HypGly in the plasma was low after the ingestion of CP and CTP-100 but higher after the ingestion of CTP-50. Overall, our results suggest that tripeptides derived from collagen are absorbed efficiently by the body.

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“…First studies showed, that chicken collagen hydrolysate exerted an antihypertensive effect in spontaneous hypertensive rats [20]. Recently, this effect was confirmed in a clinical study [19]. Additionally, collagen-derived inhibitory peptides for angiotensin I converting enzyme (ACE) have been isolated as the active entity [21].…”

Section: Resultsmentioning

confidence: 95%

Influence of physically crosslinked gelatins on the vasculature in the avian chorioallantoic membrane

Krüger

Görs

Zaupa

et al. 2013

Clinical Hemorheology and Microcirculation

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Gelatins functionalized with desaminotyrosine (DAT) or desaminotyrosyl tyrosine (DATT) form physically crosslinked hydrogels, due to the interactions between the introduced aromatic moieties and gelatin triple helices, whose extent depends on the thermal treatment of the material. The G-modulus of these hydrogels can be tailored to the range of the natural extracellular matrix by adjusting the degree of crosslinking. While these gelatin-based materials have been shown to be not angiogenic, the aim of the study was to evaluate whether these biomaterials influence the regulation of blood vessels when positioned on the chorionallantoic membrane (CAM) of fertilized eggs.The results clearly indicate that the DAT-functionalized gelatin led to an increase of the diameter of the blood vessels in the CAM, which at the same time is probably associated with an increased blood flow in these CAM vessels. The vessel diameters of the four groups (DAT-functionalized gelatin, DATT-functionalized gelatin, plain gelatin, control group without gelatin, each n = 10) differed significantly (p < 0.0001). Vessels in the CAM exposed to the DAT-functionalized gelatin showed with 36.4 m ± 3.4 m the largest mean diameters compared to the mean diameters of the samples exposed to DATT gelatin (16.0 m ± 0.8 m; p < 0.05) and the plain gelatin (21.2 m ± 1.0 m; p < 0.05), which both did not differ significantly from the vessels of the control group.The biocompatibility of the materials in vitro motivates the exploration of their application as matrix in local drug-release systems with short half-life times (one hour up to several days).

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Antihypertensive Effects and Endothelial Progenitor Cell Activation by Intake of Chicken Collagen Hydrolysate in Pre- and Mild-Hypertension

Cited by 33 publications

References 13 publications

Role of dietary proteins and peptides in cardiovascular disease

Role of dietary proteins and peptides in cardiovascular disease

Absorption and Urinary Excretion of Peptides after Collagen Tripeptide Ingestion in Humans

Influence of physically crosslinked gelatins on the vasculature in the avian chorioallantoic membrane

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