Antihypertensive effects and safety of eprosartan: a meta-analysis of randomized controlled trials

Abstract

Eprosartan monotherapy is equivalent to many first-line antihypertensive agents and is effective for the treatment of essential hypertension, especially for isolated systolic hypertension. The favorable efficacy and tolerability make eprosartan worthwhile to be taken into consideration by physicians.

Effect of eprosartan-based therapy on systolic blood pressure and total cardiovascular risk in a large international population: preliminary report of the observational POWER study

“…This experience is consistent with other reports of eprosartan 9,10. The overall profile of antihypertensive efficacy with favorable tolerability seen with once-daily eprosartan in POWER is consistent with, and supplements in circumstances of routine practice, data from controlled trials of angiotensin II receptor blockers, as recently reviewed 11,12.…”

Comparative Effectiveness of Angiotensin II Receptor Blockers in Patients With Hypertension in Japan ― Systematic Review and Network Meta-Analysis ―

“…Because ARBs are widely used, not only in Japan, but also world-wide, meta-analyses examining the efficacy among ARBs have been conducted. [29][30][31][32][33][34] We searched PubMed (on November 22, 2019) using the search terms "metaanalysis azilsartan", which identified 2 meta-analyses focusing on the antihypertensive effects of azilsartan. 35,36 The results from the present analysis are consistent with both published meta-analyses.…”

Identification of novel antifungal agents: antimicrobial evaluation, SAR, ADME–Tox and molecular docking studies of a series of imidazole derivatives

“…Indeed, this type of compounds act as inhibitors of p38 MAP kinase and B-Raf [15], and showed anti-inflammatory, anti-cancer, antifungal, anti-tuberculosis, and anti-diabetic activities [16–18]. Accordingly, several imidazole-based heterocyclic compounds have been clinically used to treat many diseases such as Bifonazole which is a clinically used antifungal agent with a broad spectrum of activity [19, 20], Metronidazole used to treat a wide variety of bacterial and parasitic infections [21], Cimetidine used in the treatment of duodenal and gastric ulcers [22], and Eprosartan used as angiotensin II inhibitor and antihypertensive agent [23].…”